CAS 51798-45-9

Elastatinal

Descrição:

Elastatinal é um composto químico classificado como um peptídeo cíclico, especificamente um membro dos inibidores de elastase. É derivado de fontes naturais, particularmente de certas espécies de fungos. O composto exibe uma notável atividade biológica, principalmente como um inibidor da elastase, uma enzima que decompõe a elastina, uma proteína chave nos tecidos conectivos. Essa inibição pode ter implicações em vários processos fisiológicos e aplicações terapêuticas potenciais, particularmente em condições caracterizadas por atividade excessiva de elastase, como a doença pulmonar obstrutiva crônica (DPOC) e certos distúrbios inflamatórios. Elastatinal é caracterizado por sua estrutura cíclica única, que contribui para sua estabilidade e especificidade na ligação à elastase. Além disso, tem sido estudado por seu papel potencial no desenvolvimento de medicamentos devido à sua capacidade de modular a atividade proteolítica. Assim como muitos compostos bioativos, mais pesquisas são necessárias para entender completamente seus mecanismos de ação, farmacocinética e potenciais efeitos colaterais em ambientes clínicos.

Fórmula: C₂₁H₃₆N₈O₇

InChI: InChI=1S/C21H36N8O7/c1-10(2)8-14(19(34)35)28-21(36)29-16(12-6-7-24-20(23)27-12)18(33)26-13(4-5-15(22)31)17(32)25-11(3)9-30/h9-14,16H,4-8H2,1-3H3,(H2,22,31)(H,25,32)(H,26,33)(H,34,35)(H3,23,24,27)(H2,28,29,36)/t11-,12-,13-,14-,16-/m0/s1

Chave InChI: InChIKey=IJWCGVPEDDQUDE-YGJAXBLXSA-N

SMILES: [C@H](C(N[C@H](C(N[C@H](C=O)C)=O)CCC(N)=O)=O)(NC(N[C@@H](CC(C)C)C(O)=O)=O)[C@]1(NC(N)=NCC1)[H]

Sinónimos:

• (2S)-2-[(4S)-2-Amino-3,4,5,6-tetrahydro-4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N¹-[(1S)-1-methyl-2-oxoethyl]-<span class="text-smallcaps">L</span>-glutamamide
• (2S,6S,9S,12S)-9-(3-amino-3-oxopropyl)-6-[(4S)-2-amino-3,4,5,6-tetrahydropyrimidin-4-yl]-12-methyl-2-(2-methylpropyl)-4,7,10,13-tetraoxo-3,5,8,11-tetraazatridecan-1-oic acid (non-preferred name)
• (2S,9S)-9-(3-amino-3-oxopropyl)-6-(2-amino-3,4,5,6-tetrahydropyrimidin-4-yl)-12-methyl-2-(2-methylpropyl)-4,7,10,13-tetraoxo-3,5,8,11-tetraazatridecan-1-oic acid (non-preferred name)
• 9-(3-Amino-3-Oxopropyl)-6-(2-Amino-3,4,5,6-Tetrahydropyrimidin-4-Yl)-12-Methyl-2-(2-Methylpropyl)-4,7,10,13-Tetraoxo-3,5,8,11-Tetraazatridecan-1-Oic Acid (Non-Preferred Name)
• <span class="text-smallcaps">L</smallcap>-Glutamamide, <smallcap>L</span>-2-(2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl)-N-[[(1-carboxy-3-methylbutyl)amino]carbonyl]glycyl-N¹-(1-methyl-2-oxoethyl)-, stereoisomer
• <span class="text-smallcaps">L</span>-Glutamamide, (2S)-2-[(4S)-2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N¹-[(1S)-1-methyl-2-oxoethyl]-
• <span class="text-smallcaps">L</span>-Glutamamide, (2S)-2-[(4S)-2-amino-3,4,5,6-tetrahydro-4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N¹-[(1S)-1-methyl-2-oxoethyl]-
• Elastatinal
• N~2~-[(2S)-2-[(4S)-2-amino-3,4,5,6-tetrahydropyrimidin-4-yl]-2-({[(2S)-4-methyl-1-oxopentan-2-yl]carbamoyl}amino)acetyl]-N~1~-[(2S)-1-oxopropan-2-yl]-L-glutamamide
• L-Glutamamide, (2S)-2-[(4S)-2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N1-[(1S)-1-methyl-2-oxoethyl]-
• L-Glutamamide, (2S)-2-[(4S)-2-amino-3,4,5,6-tetrahydro-4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N1-[(1S)-1-methyl-2-oxoethyl]-
• L-Glutamamide, L-2-(2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl)-N-[[(1-carboxy-3-methylbutyl)amino]carbonyl]glycyl-N1-(1-methyl-2-oxoethyl)-, stereoisomer

Elastatinal

CAS: 51798-45-9

Fórmula: C₂₁H₃₆N₈O₇

Pureza: 85%

Peso molecular: 512.5599

Ref: IN-DA01E4MS

Elastatinal

CAS: 51798-45-9

Elastatinal is an elastase inhibitor. It is found in culture filtrates of various species of actinomyces.

Fórmula: C₂₁H₃₆N₈O₇

Cor e Forma: Yellowish Solid

Peso molecular: 512.56

Ref: TM-T20130

Elastatinal microbial

CAS: 51798-45-9

Fórmula: C₂₁H₃₆N₈O₇

Pureza: ~0.64μg/ml (IC50, pH8.8, 37°C)

Cor e Forma: White to light-yellow or tan powder

Peso molecular: 512.60

Ref: 7W-GL1320

Elastatinal

CAS: 51798-45-9

Elastatinal is a natural product that has been shown to inhibit the protease activity of HIV-1. This inhibition may be due to its ability to bind to the cell surface and prevent the assembly of the virus-cell complex. Elastatinal binds to hydroxyl groups on proteins, which may inhibit enzymes in cells by preventing them from carrying out their functions. The biological sample can be any type of biological fluid or tissue, such as blood, saliva, semen, and vaginal secretions. Elastatinal is a natural product that has been shown to inhibit the protease activity of HIV-1. This inhibition may be due to its ability to bind to the cell surface and prevent the assembly of the virus-cell complex. Elastatinal binds to hydroxyl groups on proteins, which may inhibit enzymes in cells by preventing them from carrying out their functions. The biological sample can be any type of biological fluid or tissue, such as blood, saliva, semen, and

Fórmula: C₂₁H₃₆N₈O₇

Pureza: Min. 95%

Peso molecular: 512.56 g/mol

Ref: 3D-IEL-4064

Elastatinal

Produto Controlado

CAS: 51798-45-9

Applications Elastatinal is an elastase inhibitor.

Fórmula: C₂₁H₃₆N₈O₇

Cor e Forma: Neat

Peso molecular: 512.56

Ref: TR-E501008

Elastatinal

CAS: 51798-45-9

Elastatinal is a research tool that is used to activate cells by binding to a receptor on the cell surface. Elastatinal belongs to the Ligand class of compounds and has been shown to bind to various ion channels and receptors, including cell surface receptors. This ligand binds with high affinity to the α-adrenergic receptor (α-AR) and activates cells that express this receptor. It also inhibits the binding of other ligands, such as bradykinin, which may be useful in pharmacology. Elastatinal is an inhibitor of protein interactions, which can be used in Cell Biology studies.

Fórmula: C₂₁H₃₆N₈O₇

Pureza: Min. 95%

Peso molecular: 512.56 g/mol

Ref: 3D-IEL-4064-V

Elastatinal

CAS: 51798-45-9

Irreversible elastase inhibitor This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Fórmula: C₂₁H₃₆N₈O₇

Peso molecular: 512.6

Ref: 02-J61120