CAS 52-01-7

Espironolactona

Descrição:

Espironolactona é um composto esteroide sintético usado principalmente como diurético e agente antihipertensivo. Funciona como um antagonista da aldosterona, inibindo a ação da aldosterona nos rins, o que promove a excreção de sódio e água enquanto conserva potássio. Esse mecanismo o torna eficaz no tratamento de condições como hipertensão, insuficiência cardíaca e certos casos de edema. Espironolactona também é utilizado no manejo de condições como hiperaldosteronismo e pode ser benéfico no tratamento de acne e hirsutismo devido às suas propriedades antiandrogênicas. O composto é tipicamente administrado por via oral e tem uma meia-vida relativamente longa, permitindo a dosagem uma vez ao dia em muitos casos. Em termos de sua estrutura química, Espironolactona apresenta um anel de lactona e um grupo tioéster, contribuindo para sua atividade farmacológica. Efeitos colaterais comuns podem incluir hipercalemia, distúrbios gastrointestinais e desequilíbrios hormonais. Devido aos seus efeitos hormonais, Espironolactona às vezes é usado off-label em terapia hormonal para indivíduos transgêneros. No geral, Espironolactona é um medicamento versátil com aplicações terapêuticas significativas em várias condições médicas.

Fórmula: C₂₄H₃₂O₄S

InChI: InChI=1S/C24H32O4S/c1-14(25)29-19-13-15-12-16(26)4-8-22(15,2)17-5-9-23(3)18(21(17)19)6-10-24(23)11-7-20(27)28-24/h12,17-19,21H,4-11,13H2,1-3H3/t17-,18-,19+,21+,22-,23-,24+/m0/s1

Chave InChI: InChIKey=LXMSZDCAJNLERA-ZHYRCANASA-N

SMILES: C[C@@]12[C@]3(CC[C@]1([C@]4([C@](CC2)([C@]5(C)C(C[C@H]4SC(C)=O)=CC(=O)CC5)[H])[H])[H])OC(=O)CC3

Sinónimos:

• (7α,17α)-7-(Acetylthio)-17-hydroxy-3-oxo-pregn-4-ene-21-carboxylic acid γ-lactone
• 17-Hydroxy-7-alpha-mercapto-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid-gamma-lactone-7-acetate
• 17-Hydroxy-7α-mercapto-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactone 7-acetate
• 17α-Pregn-4-ene-21-carboxylic acid, 17-hydroxy-7α-mercapto-3-oxo-, γ-lactone, acetate
• 3'-(3-Oxo-7α-acetylthio-17β-hydroxyandrost-4-en-17α-yl)-propionic acid lactone
• 3-(3-Oxo-7α-acetylthio-17β-hydroxy-4-androsten-17α-yl)propionic acid-γ-lactone
• 3-(3-keto-7α-Acetylthio-17β-hydroxy-4-androsten-17α-yl)propionic acid lactone
• 7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta-
• 7α-(Acetylthio)-17-hydroxy-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactone
• 7α-Acetylthio-3-oxo-17α-pregn-4-ene-21,17β-carbolactone
• Abbolactone
• Aldace
• Aldactone
• Aldactone A
• Aldopur
• Almatol
• Altex
• Aquareduct
• Berlactone
• Deverol
• Diatensec
• Dira
• Duraspiron
• Espironolactona
• Euteberol
• Lacalmin
• Lacdene
• Laractone
• Nefurofan
• Novo-Spiroton
• Nsc 150399
• Osiren
• Osyrol
• Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, γ-lactone, (7α,17α)-
• Quimolactona
• S-(10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-yl) ethanethioate
• S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-yl] ethanethioate
• S-[(7R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-yl] ethanethioate
• Sagisal
• Sc 9420
• Sincomen
• Spiresis
• Spiretic
• Spiridon
• Spiro-Tablinen
• Spiro[17H-cyclopenta[a]phenanthrene-17,2′(5′H)-furan], pregn-4-ene-21-carboxylic acid deriv.
• Spiroctan
• Spiroderm
• Spirolactone
• Spirolang
• Spirolone
• Spirone
• Spironol
• Spironolacton
• Spironolactone A
• Supra-Puren
• Suracton
• Uractone
• Urusonin
• Verospiron
• Verospirone
• Xenalon

Spironolactone-d3

Produto Controlado

CAS: 52-01-7

Applications Spironolactone-d3 is the labeled analogue of Spironolactone (S683000), a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia, and Conn’s syndrome.
References Sutter, J.L., et al.: Anal. Profiles Drug Subs., 4, 431 (1975)

Fórmula: C₂₄H₂₉D₃O₄S

Cor e Forma: Yellow Solid

Peso molecular: 419.59

Ref: TR-S683003

Spironolactone

Produto Controlado

CAS: 52-01-7

Applications It is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia, and Conn’s syndrome.
References Sutter, J.L., et al.: Anal. Profiles Drug Subs., 4, 431 (1975),

Fórmula: C₂₄H₃₂O₄S

Cor e Forma: Off-White

Peso molecular: 416.57

Ref: TR-S683000

Spironolactone-d7 (Major)

Produto Controlado

CAS: 52-01-7

Applications It is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia, and Conn’s syndrome. A representative lot was 19% d3; 47% d6; 12% d7; 7% d8; 3% d9; 3% d10 and 8% d11.
References Sutter, J.L., et al.: Anal. Profiles Drug Subs., 4, 431 (1975),

Fórmula: C₂₄H₂₅D₇O₄S

Cor e Forma: Neat

Peso molecular: 423.62

Ref: TR-S683002

Spironolactone

Produto Controlado

CAS: 52-01-7

Mineralocorticoid (aldosterone) receptor antagonist; anti-hypertensive

Fórmula: C₂₄H₃₂O₄S

Pureza: Min. 97 Area-%

Cor e Forma: White Powder

Peso molecular: 416.57 g/mol

Ref: 3D-FS15791

Spironolactone - Bio-X ™

Produto Controlado

CAS: 52-01-7

Spironolactone is an aldosterone receptor antagonist that is used to treat hypertension, heart failure and edema. This drug binds to mineralocorticoid receptors and acts as an aldosterone antagonist. Spironolactone promotes sodium and water excretion and potassium retention. It also activates pro-inflammatory pathways.

Fórmula: C₂₄H₃₂O₄S

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 416.57 g/mol

Ref: 3D-BS166385

Spironolactone extrapure, 97%

CAS: 52-01-7

Fórmula: C₂₄H₃₂O₄S

Pureza: min. 97%

Cor e Forma: White, Powder

Peso molecular: 416.60

Ref: SR-67715

17-Hydroxy-7-α-mercapto-3-oxo-17-α-pregn-4-ene-21-carboxylic acid-γ-lactone-7-acetate

CAS: 52-01-7

Fórmula: C₂₄H₃₂O₄S

Pureza: 97%

Cor e Forma: Solid

Peso molecular: 416.5735

Ref: IN-DA00DE6I