CAS 52050-17-6

Glucosilsfingosina

Descrição:

Glucosilsfingosina, também conhecido como glucosilceramida, é um glicosfingolípido caracterizado pela presença de uma molécula de glicose ligada a uma estrutura de esfingosina. Desempenha um papel crucial nos processos celulares, incluindo sinalização celular e estrutura de membrana. Este composto é particularmente significativo no contexto de certos distúrbios metabólicos, como a doença de Gaucher, onde sua acumulação pode levar a vários problemas de saúde. Glucosilsfingosina é tipicamente encontrado nas membranas das células, especialmente no sistema nervoso e nas células imunológicas, contribuindo para a formação de balsas lipídicas que facilitam a comunicação celular. Sua estrutura consiste em um ácido graxo de cadeia longa ligado à esfingosina, o que influencia suas propriedades físicas e funções biológicas. O composto é solúvel em solventes orgânicos, mas tem solubilidade limitada em água, refletindo sua natureza anfipática. Compreender as características de Glucosilsfingosina é essencial para explorar seu papel na saúde e na doença, bem como seu potencial como alvo terapêutico em distúrbios do metabolismo de esfingolípidos.

Fórmula: C₂₄H₄₇NO₇

InChI: InChI=1S/C24H47NO7/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(27)18(25)17-31-24-23(30)22(29)21(28)20(16-26)32-24/h14-15,18-24,26-30H,2-13,16-17,25H2,1H3/b15-14+/t18-,19+,20+,21+,22-,23+,24+/m0/s1

Chave InChI: InChIKey=HHJTWTPUPVQKNA-JIAPQYILSA-N

SMILES: O(C[C@@H]([C@@H](/C=C/CCCCCCCCCCCCC)O)N)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O

Sinónimos:

• (2S,3R,4E)-2-Amino-3-hydroxy-4-octadecen-1-yl β-<span class="text-smallcaps">D</span>-glucopyranoside
• (3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl beta-D-mannopyranoside
• Glucosyl psychosine
• Glucosyl sphingosine
• Glucosyl-C₁₈-sphingosine
• Glucosylsphingosine
• Sphingosyl beta-glucoside
• beta-D-Glucopyranoside, 2-amino-3-hydroxy-4-octadecenyl, (R-(R*,S*-(E)))-
• β-<span class="text-smallcaps">D</span>-Glucopyranoside, (2S,3R,4E)-2-amino-3-hydroxy-4-octadecen-1-yl
• β-<span class="text-smallcaps">D</span>-Glucopyranoside, (2S,3R,4E)-2-amino-3-hydroxy-4-octadecenyl
• β-<span class="text-smallcaps">D</span>-Glucopyranoside, 2-amino-3-hydroxy-4-octadecenyl, [R-[R*,S*-(E)]]-
• Glucosyl-C18-sphingosine
• β-D-Glucopyranoside, (2S,3R,4E)-2-amino-3-hydroxy-4-octadecenyl
• Glucopsychosine
• β-D-Glucopyranoside, 2-amino-3-hydroxy-4-octadecenyl, [R-[R*,S*-(E)]]-
• Glcsph d18:1 (GlcbSphingolipids)
• β-D-Glucopyranoside, (2S,3R,4E)-2-amino-3-hydroxy-4-octadecen-1-yl

Glucosylsphingosine

CAS: 52050-17-6

Glucosylsphingosine (Lyso-Gb1) is a glycosyl ceramide that accumulates in neurodegenerative disorders and disrupts lysosomal function by activating mTORC1.

Fórmula: C₂₄H₄₇NO₇

Cor e Forma: Solid

Peso molecular: 461.63

Ref: TM-T78493

Glucopsycosine

CAS: 52050-17-6

Glucopsycosine

Peso molecular: 461.63g/mol

Ref: 54-BI3460

Glucopsychosine

CAS: 52050-17-6

Fórmula: C24H47NO7

Pureza: >98%

Cor e Forma: Solid

Peso molecular: 461.63

Ref: 48-56-1141

Glucosylsphingosine, plant

CAS: 52050-17-6

Fórmula: C24H47NO7

Pureza: >98%

Cor e Forma: Solid

Peso molecular: 461.63

Ref: 48-56-1146

Glucosyl-C18-Sphingosine

CAS: 52050-17-6

Fórmula: C₂₄H₄₇NO₇

Peso molecular: 461.64

Ref: 4Z-S-089022

Glucosylsphingosine

CAS: 52050-17-6

Glucosylsphingosine is a modified carbohydrate that belongs to the group of complex carbohydrates. It is a custom synthesis and has high purity with no detectable impurities. Glucosylsphingosine is an oligosaccharide, which is a polysaccharide composed of three or more monosaccharides. This compound can be methylated, glycosylated, or fluorinated in order to change its properties. Glucosylsphingosine has been synthesized from glucose and sphinganine, which are both monosaccharides. Glucose can be synthesized by the reduction of glucose-6-phosphate using glucose-6-phosphate dehydrogenase or it can be obtained from hydrolysis of starch. Sphinganine can be obtained by hydrolysis of sphingomyelin, which is a phospholipid found in cell membranes or by deacylation of N-acetyl

Fórmula: C₂₄H₄₇NO₇

Pureza: Min. 95%

Peso molecular: 461.63 g/mol

Ref: 3D-MG182363

Glucosyl-C18-sphingosine

CAS: 52050-17-6

Glucosyl-C18-sphingosine is a sphingolipid that has been shown to inhibit the activity of Gaucher's enzyme, which is responsible for the synthesis of glucosylceramide. It has been demonstrated in a model system that glucosyl-C18-sphingosine inhibits mitochondrial membrane potential and decreases ATP levels, leading to cell death. The molecular pathogenesis of Gaucher disease is not well understood but it is believed to be related to defective lysosomal function. Glucosyl-C18-sphingosine may be used as a diagnostic agent for Gaucher disease and other metabolic disorders involving glucosylceramide accumulation.

Fórmula: C₂₄H₄₇NO₇

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 461.63 g/mol

Ref: 3D-MG23669

Glucosyl-C18-sphingosine-d5

Produto Controlado

CAS: 52050-17-6

Fórmula: C₂₄H₄₂D₅NO₇

Cor e Forma: Neat

Peso molecular: 466.67

Ref: TR-G596841

Glucosyl-C18-sphingosine

CAS: 52050-17-6

Applications A sphingosine derivative. A sphingolipid compound found in the umbilical cord artery of women with preeclampsia.
References Romanowicz, L. et al.: Mol. Cell. Biochem. 340, 81 (2010);

Fórmula: C₂₄H₄₇NO₇

Cor e Forma: Neat

Peso molecular: 461.63

Ref: TR-G596840