CAS 522-17-8

Deguelina

Descrição:

Deguelina é um composto que ocorre naturalmente classificado como um flavonoide, especificamente um membro da família dos rotenoides. É derivado principalmente de várias espécies de plantas, particularmente aquelas da família Fabaceae. Deguelina exibe uma gama de atividades biológicas, incluindo propriedades anti-inflamatórias, anticancerígenas e antidiabéticas, tornando-o de interesse na pesquisa farmacológica. O composto demonstrou inibir certas enzimas e vias envolvidas na proliferação e sobrevivência de células cancerosas. Quimicamente, Deguelina é caracterizado por sua estrutura complexa, que inclui múltiplos anéis e grupos funcionais que contribuem para sua reatividade e atividade biológica. Geralmente é encontrado em forma sólida à temperatura ambiente e é solúvel em solventes orgânicos. Devido aos seus potenciais benefícios terapêuticos, Deguelina tem atraído atenção nos campos da química medicinal e pesquisa de produtos naturais, embora mais estudos sejam necessários para entender completamente seus mecanismos de ação e aplicações potenciais em ambientes clínicos.

Fórmula: C₂₃H₂₂O₆

InChI: InChI=1/C23H22O6/c1-23(2)8-7-12-15(29-23)6-5-13-21(24)20-14-9-17(25-3)18(26-4)10-16(14)27-11-19(20)28-22(12)13/h5-10,19-20H,11H2,1-4H3/t19-,20+/m1/s1

Chave InChI: InChIKey=ORDAZKGHSNRHTD-UXHICEINSA-N

SMILES: O=C1C=2C(=C3C(=CC2)OC(C)(C)C=C3)O[C@]4([C@@]1(C=5C(OC4)=CC(OC)=C(OC)C5)[H])[H]

Sinónimos:

• (-)-cis-Deguelin
• (7aS,13aS)-13,13a-Dihydro-9,10-dimethoxy-3,3-dimethyl-3H-bis[1]benzopyrano[3,4-b:6′,5′-e]pyran-7(7aH)-one
• (7aS,13aS)-9,10-Dimethoxy-3,3-dimethyl-13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-on
• (7aS-cis)-13,13a-Dihydro-9,10-dimethoxy-3,3-dimethyl-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(7aH)-one
• 3H-Bis(1)benzopyrano(3,4-b:6',5'-e)pyran-7(7aH)-one, 13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-, (7aS,13aS)-
• 3H-Bis(1)benzopyrano(3,4-b:6',5'-e)pyran-7(7aH)-one, 13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-, (7aS-cis)-
• 3H-Bis[1]benzopyrano[3,4-b:6′,5′-e]pyran-7(7aH)-one, 13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-
• 3H-Bis[1]benzopyrano[3,4-b:6′,5′-e]pyran-7(7aH)-one, 13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-, (7aS,13aS)-
• 3H-Bis[1]benzopyrano[3,4-b:6′,5′-e]pyran-7(7aH)-one, 13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-, (7aS-cis)-
• 3H-[1]Benzopyrano[3,4-b]pyrano[2,3-h][1]benzopyran-7(7aH)-one, 13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-, (7aS,13aS)-
• 3H-pyrano[2',3':7,8][1]benzopyrano[2,3-c][1]benzopyran-7(7aH)-one, 13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-, (7aS,13aS)-
• Deguelin
• (7aS,13aS)-9,10-Diméthoxy-3,3-diméthyl-13,13a-dihydro-3H-chroméno[3,4-b]pyrano[2,3-h]chromén-7(7aH)-one
• (7aS)-3,3-Dimethyl-9,10-dimethoxy-7,7aα,13,13aα-tetrahydro-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7-one
• (7AS,13AS)-13,13A-DIHYDRO-9,10-DIMETHOXY-3,3-DIMETHYL-3H-BIS[1]BENZOPYRANO[3,4-B:6',5'-E]PYRAN-7(7AH)-ONE
• (7as-cis)-oxy-
• 3h-bis(1)benzopyrano(3,4-b:6’,5’-e)pyran-7(7ah)-one,13,13a-dihydro-9,10-dimeth
• (7aS,13aS)-9,10-Dimethoxy-3,3-dimethyl-13,13a-dihydro-3H-pyrano[2,3-c:6,5-f']dichromen-7(7aH)-one
• 3,3-Dimethyl-9,10-dimethoxy-7,7aα,13,13aα-tetrahydro-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7-one
• (-)-DEGUELIN;(-)-CIS-DEGUELIN
• Deguelin (6CI)
• 12a-DEOXYTEPHROSIN
• (7aS,13aS)-13,13a-Dihydro-9,10-dimethoxy-3,3-dimethyl-(3H)-bis[1]benzopyrano[3.4-b.6'.5'-e]pyran-7(7aH)-one

Deguelin

CAS: 522-17-8

Fórmula: C₂₃H₂₂O₆

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 394.4172

Ref: IN-DA00D7ZC

Deguelin

CAS: 522-17-8

Deguelin

Pureza: ≥95%

Peso molecular: 394.42g/mol

Ref: 54-BUP10439

(-)-Deguelin

CAS: 522-17-8

Fórmula: C₂₃H₂₂O₆

Pureza: ≥ 98.0%

Cor e Forma: White to beige powder

Peso molecular: 394.42

Ref: 7W-GL4230

(7As,13As)-9,10-Dimethoxy-3,3-Dimethyl-13,13A-Dihydro-3H-Pyrano[2,3-C:6,5-F']Dichromen-7(7Ah)-One

CAS: 522-17-8

(7As,13As)-9,10-Dimethoxy-3,3-Dimethyl-13,13A-Dihydro-3H-Pyrano[2,3-C:6,5-F']Dichromen-7(7Ah)-One

Pureza: 98%

Peso molecular: 394.42g/mol

Ref: 54-OR1026149

Deguelin

CAS: 522-17-8

Fórmula: C₂₃H₂₂O₆

Pureza: 95%~99%

Cor e Forma: Powder

Peso molecular: 394.423

Ref: BP-BP3110

Deguelin

CAS: 522-17-8

Deguelin ((-)-Deguelin) is a PI3K/AKT Inhibitor, which is a natural product isolated from plants in the Mundulea sericea family.

Fórmula: C₂₃H₂₂O₆

Pureza: 96.39% - 99.29%

Cor e Forma: Solid

Peso molecular: 394.42

Ref: TM-T6817

Deguelin

CAS: 522-17-8

Oxygen-heterocyclic compound

Fórmula: C₂₃H₂₂O₆

Pureza: ≥ 95.0 % (HPLC)

Cor e Forma: Powder

Peso molecular: 394.42

Ref: 5G-22641

Deguelin

Produto Controlado

CAS: 522-17-8

Applications Deguelin exhibits potent apoptotic and antiangiogenic activities in a variety of transformed cells and cancer cells. Deguelin also exhibits potent tumor suppressive effects in xenograft tumor models for many human cancers.
References Chang, D.J.. et al.: J. Med. Chem., 55, 10863 (2012);

Fórmula: C₂₃H₂₂O₆

Cor e Forma: Light Yellow

Peso molecular: 394.42

Ref: TR-D229205

(-)-Deguelin

CAS: 522-17-8

Fórmula: C₂₃H₂₂O₆

Pureza: >95.0%(HPLC)

Cor e Forma: White to Yellow to Green powder to crystal

Peso molecular: 394.42

Ref: 3B-D5646

Deguelin

CAS: 522-17-8

Deguelin is a rotenoid, which is a naturally occurring compound derived primarily from the roots of plants in the Leguminosae family, such as Mundulea sericea and Derris species. It functions as a potent inhibitor of mitochondrial complex I, interfering with cellular respiration by blocking electron transport within the mitochondrial electron transport chain. This action leads to the inhibition of ATP production, which is essential for cellular energy.

Fórmula: C₂₃H₂₂O₆

Pureza: Min. 95%

Peso molecular: 394.42 g/mol

Ref: 3D-FD65404

DEGUELIN

CAS: 522-17-8

Pureza: 98%

Peso molecular: 394.4230042

Ref: 10-F814502