CAS 52232-67-4

Teriparatida

Descrição:

Teriparatida é uma forma sintética do hormônio paratireoideano (PTH) usada principalmente no tratamento da osteoporose. É caracterizada pela sua capacidade de estimular a formação óssea, o que a torna distinta de outros tratamentos para osteoporose que se concentram principalmente na inibição da reabsorção óssea. Teriparatida é administrado por injeção subcutânea e geralmente é prescrito para pacientes com alto risco de fraturas. A substância é composta pelos primeiros 34 aminoácidos da PTH humana, que são cruciais para sua atividade biológica. Seu mecanismo de ação envolve a ligação aos receptores de PTH nos osteoblastos, promovendo o crescimento ósseo e aumentando a absorção de cálcio nos intestinos e rins. Teriparatida tem uma meia-vida relativamente curta, necessitando de administração diária para efeitos terapêuticos ideais. Efeitos colaterais comuns podem incluir náuseas, tontura e cãibras nas pernas. Devido aos seus efeitos anabólicos sobre o osso, Teriparatida é frequentemente considerado para uso em mulheres pós-menopáusicas e homens com osteoporose que têm histórico de fraturas ou perda óssea significativa.

Fórmula: C₁₈₁H₂₉₁N₅₅O₅₁S₂・C₂H₄O<

InChI: InChI=1/C181H291N55O51S2/c1-21-96(18)146(236-160(267)114(48-53-141(250)251)212-174(281)132(84-239)232-177(284)143(93(12)13)233-147(254)103(185)82-237)178(285)216-111(45-50-134(187)241)155(262)219-119(65-90(6)7)163(270)213-116(55-62-289-20)158(265)224-124(71-100-79-196-86-203-100)167(274)226-126(73-135(188)242)169(276)217-117(63-88(2)3)148(255)201-81-138(245)205-105(39-27-30-56-182)149(256)223-123(70-99-78-195-85-202-99)166(273)221-121(67-92(10)11)164(271)225-128(75-137(190)244)171(278)231-131(83-238)173(280)214-115(54-61-288-19)157(264)210-112(46-51-139(246)247)153(260)208-109(43-34-60-199-181(193)194)159(266)234-144(94(14)15)175(282)215-113(47-52-140(248)249)156(263)222-122(69-98-77-200-104-38-26-25-37-102(98)104)165(272)220-120(66-91(8)9)161(268)209-108(42-33-59-198-180(191)192)151(258)206-106(40-28-31-57-183)150(257)207-107(41-29-32-58-184)152(259)218-118(64-89(4)5)162(269)211-110(44-49-133(186)240)154(261)228-129(76-142(252)253)172(279)235-145(95(16)17)176(283)229-125(72-101-80-197-87-204-101)168(275)227-127(74-136(189)243)170(277)230-130(179(286)287)68-97-35-23-22-24-36-97/h22-26,35-38,77-80,85-96,103,105-132,143-146,200,237-239H,21,27-34,39-76,81-84,182-185H2,1-20H3,(H2,186,240)(H2,187,241)(H2,188,242)(H2,189,243)(H2,190,244)(H,195,202)(H,196,203)(H,197,204)(H,201,255)(H,205,245)(H,206,258)(H,207,257)(H,208,260)(H,209,268)(H,210,264)(H,211,269)(H,212,281)(H,213,270)(H,214,280)(H,215,282)(H,216,285)(H,217,276)(H,218,259)(H,219,262)(H,220,272)(H,221,273)(H,222,263)(H,223,256)(H,224,265)(H,225,271)(H,226,274)(H,227,275)(H,228,261)(H,229,283)(H,230,277)(H,231,278)(H,232,284)(H,233,254)(H,234,266)(H,235,279)(H,236,267)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,286,287)(H4,191,192,198)(H4,193,194,199)

SMILES: CCC(C)C(C(=NC(CCC(=N)O)C(=NC(CC(C)C)C(=NC(CCSC)C(=NC(Cc1cnc[nH]1)C(=NC(CC(=N)O)C(=NC(CC(C)C)C(=NCC(=NC(CCCCN)C(=NC(Cc1cnc[nH]1)C(=NC(CC(C)C)C(=NC(CC(=N)O)C(=NC(CO)C(=NC(CCSC)C(=NC(CCC(=O)O)C(=NC(CCCNC(=N)N)C(=NC(C(C)C)C(=NC(CCC(=O)O)C(=NC(Cc1c[nH]c2ccccc12)C(=NC(CC(C)C)C(=NC(CCCNC(=N)N)C(=NC(CCCCN)C(=NC(CCCCN)C(=NC(CC(C)C)C(=NC(CCC(=N)O)C(=NC(CC(=O)O)C(=NC(C(C)C)C(=NC(Cc1cnc[nH]1)C(=NC(CC(=N)O)C(=NC(Cc1ccccc1)C(=O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C(C(CCC(=O)O)N=C(C(CO)N=C(C(C(C)C)N=C(C(CO)N)O)O)O)O

Sinónimos:

• Teriparatide Acetate
• Forteo
• L-Phenylalanine, L-seryl-L-valyl-L-seryl-L-alpha-glutamyl-L-isoleucyl-L-glutaminyl-L-leucyl-L-methionyl-L-histidyl-L-asparaginyl-L-leucylglycyl-L-lysyl-L-histidyl-L-leucyl-L-asparaginyl-L-seryl-L-methionyl-L-alpha-glutamyl-L-arginyl-L-valyl-L-alpha-glutamyl-L-tryptophyl-L-leucyl-L-arginyl-L-lysyl-L-lysyl-L-leucyl-L-glutaminyl-L-alpha-aspartyl-L-valyl-L-histidyl-L-asparaginyl-, acetate (salt) hydrate
• L-Seryl-L-valyl-L-seryl-L-alpha-glutamyl-L-isoleucyl-L-glutaminyl-L-leucyl-L-methionyl-L-histidyl-L-asparaginyl-L-leucylglycyl-L-lysyl-L-histidyl-L-leucyl-L-asparaginyl-L-seryl-L-methionyl-L-alpha-glutamyl-L-arginyl-L-valyl-L-alpha-glutamyl-L-tryptophyl-L-leucyl-L-arginyl-L-lysyl-L-lysyl-L-leucyl-L-glutaminyl-L-alpha-aspartyl-L-valyl-L-histidyl-L-asparaginyl-L-phenylalanine acetate (salt) hydrate
• Parathar
• Parathar acetate
• L-Phenylalanine, L-seryl-L-valyl-L-seryl-L-alpha-glutamyl-L-isoleucyl-L-glutaminyl-L-leucyl-L-methionyl-L-histidyl-L-asparaginyl-L-leucylglycyl-L-lysyl-L-histidyl-L-leucyl-L-asparaginyl-L-seryl-L-methionyl-L-alpha-glutamyl-L-arginyl-L-valyl-L-alpha-glutamyl-L-tryptophyl-L-leucyl-L-arginyl-L-lysyl-L-lysyl-L-leucyl-L-glutaminyl-L-alpha-aspartyl-L-valyl-L-histidyl-L-asparaginyl-, acetate (salt)

Parathyroid Hormone (1-34), human

CAS: 52232-67-4

Parathyroid Hormone (1-34), human

Fórmula: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Peso molecular: 4117.7

Ref: 02-J66180

pTH (1-34) (human)

CAS: 52232-67-4

Teriparatide, which consists of the N-terminal 34 amino acid residues of parathyroid hormone, shows the same potency and pharmacological profile as the native hormone. Administration of teriparatide stimulates bone formation and increases the bone mineral density (BMD).

Fórmula: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Pureza: 99.1%

Cor e Forma: White

Peso molecular: 4117.77

Ref: 01-4011474

pTH (1-34) (human)

CAS: 52232-67-4

Intermittent administration of teriparatide stimulates bone formation by increasing the number of osteoblasts. Agonist of the parathyroid hormone receptor PTH1.

Fórmula: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Pureza: 96.3%

Cor e Forma: White

Peso molecular: 4117.77

Ref: 01-4095855

TERIPARATIDE FOR SYSTEM SUITABILITY CRS

CAS: 52232-67-4

TERIPARATIDE FOR SYSTEM SUITABILITY CRS

Fórmula: C₁₃H₁₄ClNO

Peso molecular: 235.7094

Ref: 41-Y0001895

TERIPARATIDE CRS

CAS: 52232-67-4

TERIPARATIDE CRS

Fórmula: C₁₃H₁₄ClNO

Cor e Forma: Added Added

Peso molecular: 235.7094

Ref: 41-Y0001916

Teriparatide

CAS: 52232-67-4

Polypeptide, protein and glycoprotein hormones, their derivatives and structural analogues, nesoi

Fórmula: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Cor e Forma: White Off-White Powder

Peso molecular: 4115.13094

Ref: 45-1643962

Teriparatide acetate

CAS: 52232-67-4

Fórmula: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Pureza: 99%

Cor e Forma: Solid

Peso molecular: 4117.7151

Ref: IN-DA01CC00

Teriparatide Tetraacetate

CAS: 52232-67-4

Fórmula: C₁₈₁H₂₉₁N₅₅O₅₁S₂·4C₂H₄O₂

Peso molecular: 4117.77 4*60.05

Ref: 4Z-PT-255001

Teriparatide

CAS: 52232-67-4

Teriparatide is an agonist of PHT(IC50 of 2 nM in HEK293 cells).

Fórmula: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 4117.72

Ref: TM-T13128

Teriparatide acetate

CAS: 52232-67-4

Fórmula: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Peso molecular: 4117.77

Ref: 7W-GX8046

pTH (1-34) (human)

CAS: 52232-67-4

pTH (1-34) (human)

Cor e Forma: Solid

Ref: 54-BIBA1023

Parathyroid Hormone Fragment (1-34)- 24,d3 TFA Salt

Produto Controlado

CAS: 52232-67-4

Stability Hygroscopic
Applications Parathyroid Hormone Fragment (1-34)-24,d3,TFA Salt is the labeled (on Leucine-d3, position 24) analogue of Parathyroid Hormone Fragment (1-34) (P192200), which is a fragment of human parathyroid hormone (hPTH) peptide sequence containing the 34 N-terminal residues of hPTH. This fragment was also found to be an agonist at PTH1 and PTH2 receptors.
References Niall, et al.: Proc. Natl. Acad. Sci., 71, 384 (1974); Dobnig,T., et al.: Endocrinol., 138, 4607 (1997); Manabe. et al.: Bone., 40, 1475 (2007);

Fórmula: C₁₈₁D₃H₂₈₈N₅₅O₅₁S₂·xC₂O₂HF₃

Cor e Forma: Neat

Peso molecular: 4234.8

Ref: TR-P192202

Parathyroid Hormone Fragment (1-34)

Produto Controlado

CAS: 52232-67-4

Applications A fragment of human parathyroid hormone (hPTH) peptide sequence containing the 34 N-terminal residues of hPTH. This fragment was also found to be an agonist at PTH1 and PTH2 receptors.
References Niall, et al.: Proc. Natl. Acad. Sci., 71, 384 (1974); Dobnig,T., et al.: Endocrinol., 138, 4607 (1997); Manabe. et al.: Bone., 40, 1475 (2007);

Fórmula: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Cor e Forma: Neat

Peso molecular: 4117.72

Ref: TR-P192200

Teriparatide-d10

Produto Controlado

CAS: 52232-67-4

Fórmula: C₁₈₁D₁₀H₂₈₁N₅₅O₅₁S₂

Cor e Forma: Neat

Peso molecular: 4127.72

Ref: TR-T512227

Parathyroid Hormone (Human, 1-34)

CAS: 52232-67-4

This product which is available as a 0.5mg vial is amino acids 1-34 of the 84 amino acid parathyroid hormone (PTH) and can be used as an adenylate cyclase and bone growth stimulating peptide. It is possible that in can be used in research in the treatments of some types of osteoporosis.
PTH is a peptide hormone that is secreted from the parathyroid gland in the event of abnormal serum calcium levels and it ultimately regulates calcium and phosphate levels in the body. The PTH exerts its activity through binding to the G-protein coupled receptor type 1 PTH receptor, which activates adenylate cyclase or phospholipase C thus activating pathways involved in the mediation of bone resorption and bone formation. This product is suitable for life science applications.

Fórmula: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Pureza: Min. 95%

Peso molecular: 4,117.7 g/mol

Ref: 3D-PTH-4068-V

TeripaRatide Acetate

CAS: 52232-67-4

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Fórmula: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Peso molecular: 4,117.8 g/mol

Ref: 3D-PP50195

Parathyroid Hormone (Human, 1-34)

CAS: 52232-67-4

This product which is available as a 0.1mg vial is amino acids 1-34 of the 84 amino acid parathyroid hormone (PTH) and can be used as an adenylate cyclase and bone growth stimulating peptide. It is also an effective anabolic agent used in the treatment of some forms of Osteoporosis.
PTH is a peptide hormone that is secreted from the parathyroid gland in the event of abnormal serum calcium levels and it ultimately regulates calcium and phosphate levels in the body. The PTH exerts its activity through binding to the G-protein coupled receptor type 1 PTH receptor, which activates adenylate cyclase or phospholipase C thus activating pathways involved in the mediation of bone resorption and bone formation. This product is suitable for life science applications.

Fórmula: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Pureza: Min. 95%

Peso molecular: 4,117.7 g/mol

Ref: 3D-PTH-4068-S