CAS 5297-10-9

Dihidrodigoxina

Descrição:

Dihidrodigoxina é um glicosídeo cardíaco, uma classe de compostos conhecidos por sua capacidade de influenciar a função cardíaca. É derivado da planta Digitalis lanata e está estruturalmente relacionado com a digoxina, que é comumente usada no tratamento de condições cardíacas, como fibrilação atrial e insuficiência cardíaca. Dihidrodigoxina exibe um mecanismo de ação semelhante, principalmente inibindo a bomba Na+/K+ ATPase, levando ao aumento das concentrações de cálcio intracelular e à maior contratilidade cardíaca. Este composto é caracterizado por seu núcleo esteroide, que é essencial para sua atividade biológica, e normalmente tem uma alta afinidade por tecidos cardíacos. Dihidrodigoxina é menos utilizado do que a digoxina, mas pode ser de interesse na pesquisa farmacológica devido às suas propriedades únicas e potenciais aplicações terapêuticas. Assim como outros glicosídeos cardíacos, o monitoramento cuidadoso da dosagem é crucial, uma vez que a janela terapêutica é estreita e a toxicidade pode ocorrer, levando a efeitos colaterais graves.

Fórmula: C₄₁H₆₆O₁₄

InChI: InChI=1S/C41H66O14/c1-19-36(47)28(42)15-34(50-19)54-38-21(3)52-35(17-30(38)44)55-37-20(2)51-33(16-29(37)43)53-24-8-10-39(4)23(13-24)6-7-26-27(39)14-31(45)40(5)25(9-11-41(26,40)48)22-12-32(46)49-18-22/h19-31,33-38,42-45,47-48H,6-18H2,1-5H3/t19-,20-,21-,22+,23-,24+,25-,26-,27+,28+,29+,30+,31-,33+,34+,35+,36-,37-,38-,39+,40+,41+/m1/s1

Chave InChI: InChIKey=QYVJGQUFXQMOOE-STPZNEFBSA-N

SMILES: O[C@@]12[C@@](C)([C@](CC1)([C@]3(CC(=O)OC3)[H])[H])[C@H](O)C[C@]4([C@]2(CC[C@]5([C@]4(C)CC[C@H](O[C@H]6C[C@H](O)[C@H](O[C@H]7C[C@H](O)[C@H](O[C@H]8C[C@H](O)[C@H](O)[C@@H](C)O8)[C@@H](C)O7)[C@@H](C)O6)C5)[H])[H])[H]

Sinónimos:

• (3β,5β,12β)-3-[(O-2,6-Dideoxy-β-<span class="text-smallcaps">D</smallcap>-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-12,14-dihydroxycardanolide
• 20,22-Dihydrodigoxin
• 3-{[2,6-Dideoxyhexopyranosyl-(1->4)-2,6-Dideoxyhexopyranosyl-(1->4)-2,6-Dideoxyhexopyranosyl]Oxy}-12,14-Dihydroxycardanolide
• 5β-Cardanolide, 3β-[(O-2,6-dideoxy-β-<span class="text-smallcaps">D</smallcap>-ribo-hexopyranosyl-(1→4)-O-2,6-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-12β,14-dihydroxy-
• Brn 1339019
• Cardanolide, 3-((O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-12,14-dihydroxy-, (3-beta,5-beta,12-beta)-
• Cardanolide, 3-((O-2,6-dideoxy-beta-d-ribo-hexopyranosyl-(1.4)-O-2,6-dideoxy-beta-d-ribo-hexopyranosyl-(1.4)-2,6-dideoxy-beta-d-ribo-hexopyranosyl)oxy)-12,14-dihydroxy-, (3beta,5beta,12beta)-
• Cardanolide, 3-[(O-2,6-dideoxy-β-<span class="text-smallcaps">D</smallcap>-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3β,5β,12β)-
• Digoxin, 20,22-dihydro-
• Digoxin, dihydro-
• Digoxin, dihydro- (6CI)
• Dihydrodigoxin
• 5β-Cardanolide, 3β-[(O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12β,14-dihydroxy-
• (3β,5β,12β)-3-[(O-2,6-Dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxycardanolide

Dihydrodigoxin (Mixture of Diastereomers)

Produto Controlado

CAS: 5297-10-9

Applications Dihydrodigoxin is a cardioinactive metabolite of Digoxin (D446575) that gets excreted in the urine after Digoxin administration in humans.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Clark, D.R., et al.: Drug Metab. Dispos., 2, 148 (1974); Reuning, R.H., et al.: Drug Metab. Dispos., 13, 51 (1985); Butler, V.P., et al.: Pharmacology, 221, 123 (1982)

Fórmula: C₄₁H₆₆O₁₄

Cor e Forma: Neat

Peso molecular: 782.95

Ref: TR-D452680

Dihydrodigoxin

CAS: 5297-10-9

Dihydrodigoxin is a cardiac glycoside that has been used in the treatment of congestive heart failure. It is usually administered orally and can be detected by fluorescence detector because it contains a fluorescent derivative. Dihydrodigoxin has been shown to decrease renal excretion of digoxin, which may lead to drug interactions. This drug also decreases the activity of several enzymes, including dehydroascorbic acid reductase (DHAR). DHAR catalyzes the conversion of dehydroascorbic acid to ascorbic acid, which is necessary for collagen synthesis. Dihydrodigoxin also causes preeclampsia in pregnant women and decreases blood flow to the uterus.

Fórmula: C₄₁H₆₆O₁₄

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 783 g/mol

Ref: 3D-FAA29710