CAS 53-84-9

NAD

Descrição:

NAD, ou nicotinamida adenina dinucleotídeo, é uma coenzima crucial encontrada em todas as células vivas, desempenhando um papel vital nos processos metabólicos. Existe em duas formas: oxidada (NAD+) e reduzida (NADH). NAD+ é essencial para reações redox, facilitando a transferência de elétrons na respiração celular e na produção de energia. Está envolvido em várias vias bioquímicas, incluindo glicólise, ciclo do ácido cítrico e fosforilação oxidativa. Além disso, NAD+ serve como substrato para várias enzimas, incluindo desidrogenases, e é importante para a reparação do DNA e sinalização. A substância é um dinucleotídeo composto por dois nucleotídeos unidos por seus grupos fosfato, com um nucleotídeo contendo uma base de adenina e o outro contendo uma base de nicotinamida. NAD é solúvel em água e tem um peso molecular relativamente baixo. Seu papel no metabolismo celular e na transferência de energia o torna um componente crítico para manter a saúde e a função celular. Devido à sua importância, NAD e seus derivados são frequentemente estudados no contexto do envelhecimento, distúrbios metabólicos e várias doenças.

Fórmula: C₂₁H₂₇N₇O₁₄P₂

InChI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1

Chave InChI: InChIKey=BAWFJGJZGIEFAR-NNYOXOHSSA-N

SMILES: O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](COP(OP(OC[C@H]4O[C@H]([C@H](O)[C@@H]4O)[N+]=5C=C(C(N)=O)C=CC5)(=O)[O-])(=O)O)[C@H]1O

Sinónimos:

• Adenine-nicotinamide dinucleotide
• Adenosine 5'-(trihydrogen diphosphate), 5'→5'-ester with 3-(aminocarbonyl)-1-β-D-ribofuranosylpyridinium hydroxide, inner salt
• Adenosine 5'-(trihydrogen diphosphate), P'→5'-ester with 3-(aminocarbonyl)-1-β-D-ribofuranosylpyridinium hydroxide, inner salt
• Adenosine 5'-(trihydrogen diphosphate), P'→5'-ester with 3-(aminocarbonyl)-1-β-D-ribofuranosylpyridinium, inner salt
• Adenosine 5′-(trihydrogen diphosphate), P′→5′-ester with 3-(aminocarbonyl)-1-β-<span class="text-smallcaps">D</span>-ribofuranosylpyridinium hydroxide, inner salt
• Adenosine 5′-(trihydrogen diphosphate), P′→5′-ester with 3-(aminocarbonyl)-1-β-<span class="text-smallcaps">D</span>-ribofuranosylpyridinium, inner salt
• Beta-Dpn
• Co-I
• Codehydrase I
• Codehydrogenase I
• Coenzyme I
• Cozymase
• Cozymase I
• DPN
• Diphosphopyridine nucleotide
• Enzopride
• NAD
• NAD⁺
• Nadid
• Nadida
• Nadide
• Nicotinamide adenine dinucleotide
• Nsc 20272
• Oxidized diphosphopyridine nucleotide
• Pyridinium, 3-carbamoyl-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-, hydroxide, 5′→5′-ester with adenosine 5′-(trihydrogen pyrophosphate), inner salt
• Pyridinium, 3-carbamoyl-1-β-D-ribofuranosyl-, hydroxide, 5'→5'-ester with adenosine 5'-(trihydrogen pyrophosphate), inner salt
• [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl [[(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-oxido-phosphoryl] phosphate
• [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl phosphate
• beta-Diphosphopyridine nucleotide
• beta-Nicotinamide adenine dinucleotide trihydrate
• β-Diphosphopyridine nucleotide
• β-NAD
• β-NAD⁺
• β-Nicotinamide Adenine Dinuclotide
• β-Nicotinamide adenine dinucleotide
• β-Nicotinamide adenine dinucleotide hydrate

β-Nicotinamide adenine dinucleotide, 97%

CAS: 53-84-9

NAD+, Free Acid is a major electron acceptor molecule in biological oxidation reactions. It is also used as a catalyst intermediate and several enzymes in a multistep system, known as enzyme cycling,. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portf

Fórmula: C₂₁H₂₇N₇O₁₄P₂

Pureza: 97%

Cor e Forma: White to faint yellow, Powder

Peso molecular: 663.43

Ref: 02-J62337

β-Nicotinamide Adenine Dinucleotide

CAS: 53-84-9

Fórmula: C₂₁H₂₇N₇O₁₄P₂

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 663.4251

Ref: IN-DA0034IM

NAD+

CAS: 53-84-9

NAD+ is a coenzyme that facilitates electron transfer in enzymatic reactions by alternating between oxidized (NAD+) and reduced (NADH) forms.

Fórmula: C₂₁H₂₇N₇O₁₄P₂

Pureza: 98.21% - 99.47%

Cor e Forma: Off-White Solid Crystalline

Peso molecular: 663.43

Ref: TM-T1609

Nicotinamide adenine dinucleotide

CAS: 53-84-9

Nicotinamide adenine dinucleotide

Fórmula: C₂₁H₂₇N₇O₁₄P₂

Pureza: >97% free acid

Cor e Forma: Solid

Peso molecular: 663.43g/mol

Ref: 54-BIB3011

NAD+

CAS: 53-84-9

NAD+

Pureza: ≥98%

Peso molecular: 663.43g/mol

Ref: 54-BUP18555

β-Nicotinamide adenine dinucleotide

CAS: 53-84-9

Fórmula: C₂₁H₂₇N₇O₁₄P₂

Pureza: ≥ 95.0%

Cor e Forma: White to light yellow crystalline powder

Peso molecular: 663.43 (anhydrous)

Ref: 7W-GV0860

Nicotinamide Adenine Dinucleotide

CAS: 53-84-9

Fórmula: C₂₁H₂₇N₇O₁₄P₂

Peso molecular: 663.43

Ref: 4Z-N-133021

β-Nicotinamide Adenine Dinucleotide

CAS: 53-84-9

Fórmula: C₂₁H₂₇N₇O₁₄P₂

Peso molecular: 663.43

Ref: ST-EA-CP-N35008

b-Nicotinamide Adenine Dinucleotide-13C5

Produto Controlado

CAS: 53-84-9

Fórmula: C₁₆₁₃C₅H₂₇N₇O₁₄P₂

Cor e Forma: Neat

Peso molecular: 668.39

Ref: TR-N407782

β-Nicotinamide Adenine Dinucleotide-d4 (d3 major)

Produto Controlado

CAS: 53-84-9

Fórmula: C₂₁₂H₄H₂₃N₇O₁₄P₂

Cor e Forma: White To Off-White

Peso molecular: 667.45

Ref: TR-N407783

β-Nicotinamide Adenine Dinucleotide

CAS: 53-84-9

Fórmula: C₂₁H₂₇N₇O₁₄P₂

Cor e Forma: Neat

Peso molecular: 663.42

Ref: TR-N407784

β-Nicotinamide adenine dinucleotide

CAS: 53-84-9

Nicotinamide adenine dinucleotide (NAD), is a very important and essential coenzyme formed by the union of two nucleotides covalently bond to each other by their phosphates group. NAD is present in cells either in its oxidative form or in its reduced form, NAD+ and NADH respectively. They take part in many redox reactions, carrying electrons from one molecule to another.

Fórmula: C₂₁H₂₇N₇O₁₄P₂

Pureza: Min. 95 Area-%

Cor e Forma: White Powder

Peso molecular: 663.43 g/mol

Ref: 3D-NN11969

β-Nicotinamide Adenine Dinucleotide oxidized form [for Biochemical Research]

CAS: 53-84-9

Fórmula: C₂₁H₂₇N₇O₁₄P₂

Pureza: >95.0%(T)(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 663.43

Ref: 3B-D0919

ß-Nicotinamide Adenine Dinucleotide (Oxidized) (ß-NAD, DPN) extrapure, 98%

CAS: 53-84-9

Fórmula: C₂₁H₂₇N₇O₁₄P₂

Pureza: min. 98.0%

Cor e Forma: White to off-white, Crystalline powder, Clear, Colourless to pale yellow

Peso molecular: 663.44

Ref: SR-26759

ß-Nicotinamide Adenine Dinucleotide (Oxidized) (ß-NAD, DPN) ExiPlus, Multi-Compendial, 98%

CAS: 53-84-9

Fórmula: C₂₁H₂₇N₇O₁₄P₂

Pureza: min. 98.0%

Cor e Forma: White to off-white, Crystalline powder, Clear, Colourless to pale yellow

Peso molecular: 663.44

Ref: SR-19628

ß-Nicotinamide Adenine Dinucleotide (Oxidized) (ß-NAD, DPN) PrimeDx, 98%

CAS: 53-84-9

Fórmula: C₂₁H₂₇N₇O₁₄P₂

Pureza: min.98%

Cor e Forma: White to off white, Crystalline powder, Clear, Colourless to pale yellow

Peso molecular: 663.44

Ref: SR-86561

ß-Nicotinamide Adenine Dinucleotide (Oxidized) (ß-NAD, DPN) for molecular biology, 98%

CAS: 53-84-9

Fórmula: C₂₁H₂₇N₇O₁₄P₂

Pureza: min. 98.0%

Cor e Forma: White to off - white, Crystalline powder, Clear, Colourless to pale yellow

Peso molecular: 663.44

Ref: SR-87253

ß-Nicotinamide Adenine Dinucleotide (ß-NAD,DPN) for cell culture, 98%, Endotoxin (BET) 0.05EU/mg

CAS: 53-84-9

Fórmula: C₂₁H₂₇N₇O₁₄P₂

Pureza: min. 98.0%

Cor e Forma: White to off-white, Crystalline powder, Clear, Colourless to pale yellow

Peso molecular: 663.44

Ref: SR-64257

β-Nicotinamide Adenine Dinucleotide

CAS: 53-84-9

Pureza: 95+%

Cor e Forma: Solid

Peso molecular: 663.11

Ref: 10-F545316

β-Nicotinamide Adenine Dinucleotide Sodium Salt Hydrate

Produto Controlado

CAS: 20111-18-6, 53-84-9

Stability Light Sensitive
Applications β-Nicotinamide Adenine Dinucleotide is a coeznyme consisting of an adenine base and a nicotinamide base connected by a pair of bridging phosphate group. β-Nicotinamide Adenine Dinucleotide acts as a coenzyme in redox reactions, as a donor of ADP-ribose moieties in ADP-ribosylation reactions and also as a precursor of the second messenger molecule cyclic ADP-ribose. β-Nicotinamide Adenine Dinucleotide also acts as a substrate for bacterial DNA ligases and a group of enzymes called sirtuins that use NAD+ to remove acetyl groups from proteins.
References Dudev, T. et al.: J. Am. Chem. Soc., 132, 16533 (2010); Kerbey, A. et al.: Biochem. J., 154, 327 (1976); Lahiri, S.D. et al.: ACS Chem. Biol., 7, 571 (2012);

Fórmula: C₂₁H₂₆N₇O₁₄P₂·Na·xH₂O

Pureza: >85%

Cor e Forma: Neat

Peso molecular: 685.41

Ref: TR-N407775