CAS 532-40-1

Monofosfato de tiamina

Descrição:

Monofosfato de tiamina, também conhecido como fosfato de tiamina, é um derivado fosforilado da tiamina (vitamina B1). É caracterizado por seu papel como coenzima em várias reações bioquímicas, particularmente no metabolismo de carboidratos. A substância é tipicamente um pó cristalino branco a off-white que é solúvel em água, o que facilita sua atividade biológica. Monofosfato de tiamina é essencial para o funcionamento adequado das enzimas envolvidas na descarboxilação de ácidos alfa-ceto e no shunt de monofosfato de hexose. Sua presença é crucial para a produção de energia e a síntese de neurotransmissores. Em termos de estabilidade, Monofosfato de tiamina é sensível ao calor e a condições alcalinas, o que pode levar à degradação. É comumente usado em suplementos dietéticos e na fortificação de produtos alimentícios para prevenir a deficiência de tiamina, que pode levar a condições como beribéri e síndrome de Wernicke-Korsakoff. No geral, Monofosfato de tiamina desempenha um papel vital na manutenção da saúde metabólica e no suporte à função neurológica.

Fórmula: C₁₂H₁₈ClN₄O₄PS

InChI: InChI=1/C12H17N4O4PS.ClH/c1-8-11(3-4-20-21(17,18)19)22-7-16(8)6-10-5-14-9(2)15-12(10)13;/h5,7H,3-4,6H2,1-2H3,(H3-,13,14,15,17,18,19);1H

Chave InChI: InChIKey=GUGWNSHJDUEHNJ-UHFFFAOYSA-N

SMILES: C([N+]=1C(C)=C(CCOP(=O)(O)O)SC1)C=2C(N)=NC(C)=NC2.[Cl-]

Sinónimos:

• 2-(3-((6-Imino-2-methyl-1,6-dihydropyrimidin-5-yl)methyl)-4-methylthiazol-3-ium-5-yl)ethyl hydrogen phosphate hydrochloride
• 3-[(4-Amino-2-Methylpyrimidin-5-Yl)Methyl]-4-Methyl-5-[2-(Phosphonooxy)Ethyl]-1,3-Thiazol-3-Ium
• 3-[(4-Amino-2-Methylpyrimidin-5-Yl)Methyl]-4-Methyl-5-[2-(Phosphonooxy)Ethyl]-1,3-Thiazol-3-Ium Chloride
• Extraneurina
• Fosbione
• Monophosphothiamine
• Neurifosforil
• Novaneurina
• Novobeta
• Phosbitamin
• Phosphoric acid, thiamine ester
• Phosphothiamin
• Phosphothiamine
• Sineurina
• Superneurina
• TMP (thiamin ester)
• Thiamin monophosphate
• Thiamine monophosphate
• Thiamine monophosphate chloride
• Thiamine phosphate
• Thiamine phosphoric acid ester chloride
• Thiamine, dihydrogen phosphate (ester)
• Thiamine-P
• Thiazolium, 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-4-methyl-5-[2-(phosphonooxy)ethyl]-, chloride
• Thiazolium, 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-4-methyl-5-[2-(phosphonooxy)ethyl]-, chloride (1:1)
• Vitamin B1 monophosphate chloride
• Vitamin B₁ monophosphate
• Vitamin B₁ phosphate
• LABOTEST-BB LT00847627
• Phosphothiaminum
• Thiamin-p
• Thiamin monophosphate chloride
• 3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-4-methyl-5-[2-(phosphonooxy)ethyl]thiazolium
• 3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-4-methyl-5-(2-phosphonooxyethyl)thiazol-3-ium
• 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-4-methyl-5-[2-(phosphonooxy)ethyl]-thiazolium chloride
• 3-((4-aMino-2-MethylpyriMidin-5-yl)Methyl)-4-Methyl-5-(2-(phosphonooxy)ethyl)thiazol-3-iuM chloride
• Phosphoric acid 2-[[3-[(2-methyl-4-amino-5-pyrimidinyl)methyl]-4-methylthiazolium]5-yl]ethyl ester
• 3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-4-methyl-5-[2-(phosphonooxy)ethyl]thiazol-3-ium
• thiaminemonophosphate
• Thiamine-pi

Thiamine Phosphate Chloride

CAS: 532-40-1

Fórmula: C₁₂H₁₈N₄O₄PS·Cl

Cor e Forma: White To Off-White Solid

Peso molecular: 345.34 35.45

Ref: 4Z-T-8419

Thiamine monophosphate chloride

CAS: 532-40-1

Fórmula: C₁₂H₁₈N₄O₄PS·Cl

Cor e Forma: White

Peso molecular: 380.79

Ref: 04-C17455600

Vitamin B1 Monophosphate Chloride

CAS: 532-40-1

Applications Vitamin B1 Monophosphate Chloride is a precursor of thiamine pyrophosphate (T344070), a thiamine (T344185) derivative produced by enzyme thiamine pyrophosphatase. Thiamine pyrophosphate is a cofactor used to catalyze various biochemical reactions.
References Stuetz, W., et al.: PLoS One., 7, 36280 (2012); Liu, S.Q., et al.: J. Pharma. Exper. Therap., 341, 775 (2012);

Fórmula: C₁₂H₁₈N₄O₄PS·Cl

Cor e Forma: White

Peso molecular: 380.79

Ref: TR-V676015

Vitamin B1 monophosphate chloride

CAS: 532-40-1

Vitamin B1 monophosphate chloride is a metabolite of thiamine and is involved in the synthesis of nucleic acids, proteins, and lipids. It also plays an important role in energy metabolism. Vitamin B1 monophosphate chloride has been shown to have a matrix effect on axonal growth, which may be due to its ability to protect against oxidative stress by scavenging reactive oxygen species. It also has been shown to have a toxicological study that showed it was not mutagenic or carcinogenic (neither induced abnormal cell growth nor caused cancer) when administered orally to rats for 2 years at doses up to 1000 mg/kg body weight. The biological properties of Vitamin B1 monophosphate chloride are related to its ability to act as a cofactor for the enzyme pyruvate kinase, which is involved in glycolysis and gluconeogenesis, as well as being part of the pyridoxal phosphate-dependent transferase system that

Fórmula: C₁₂H₁₈ClN₄O₄PS

Pureza: Min. 95%

Peso molecular: 380.79 g/mol

Ref: 3D-AAA53240