CAS 53678-77-6

N2-[N-(N-acetilmuramoyl)-L-alanil]-D-α-glutamina

Descrição:

N2-[N-(N-acetilmuramoyl)-L-alanil]-D-α-glutamina, comumente referido como um derivado de peptidoglicano, é um composto que desempenha um papel significativo na estrutura e função da parede celular bacteriana. Esta substância é caracterizada por sua combinação única de aminoácidos e um grupo de muramilo, que é integral para a estabilidade e integridade das paredes celulares bacterianas. A presença do grupo N-acetilmuramilo contribui para sua atividade biológica, particularmente em interações com o sistema imunológico. O composto exibe propriedades típicas de peptídeos, incluindo solubilidade em água e potencial reatividade com várias moléculas biológicas. Sua estrutura permite que participe de importantes vias bioquímicas, particularmente no contexto do crescimento bacteriano e modulação da resposta imune. Além disso, devido à sua composição específica de aminoácidos, pode exibir afinidades de ligação únicas e interações enzimáticas, tornando-se um assunto de interesse em microbiologia e farmacologia. Compreender suas características pode fornecer insights sobre a fisiologia bacteriana e o desenvolvimento de agentes antimicrobianos.

Fórmula: C₁₉H₃₂N₄O₁₁

InChI: InChI=1/C19H32N4O11/c1-7(17(30)23-10(16(20)29)4-5-12(26)27)21-18(31)8(2)33-15-13(22-9(3)25)19(32)34-11(6-24)14(15)28/h7-8,10-11,13-15,19,24,28,32H,4-6H2,1-3H3,(H2,20,29)(H,21,31)(H,22,25)(H,23,30)(H,26,27)/t7-,8+,10+,11+,13+,14+,15+,19+/m0/s1

Chave InChI: InChIKey=MEJOVVKHFORGKW-HOMBLFBHSA-N

SMILES: [C@H]([C@@H](NC(C)=O)C=O)(O[C@@H](C(N[C@H](C(N[C@H](CCC(O)=O)C(N)=O)=O)C)=O)C)[C@@H]([C@@H](CO)O)O

Sinónimos:

• (4R)-4-{[(2S)-2-{[(2R)-2-{[(2R,3R,4R,5S,6R)-3-(acetylamino)-2,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl]oxy}propanoyl]amino}propanoyl]amino}-5-amino-5-oxopentanoic acid (non-preferred name)
• (4R)-4-{[(2S)-2-{[(2R)-2-{[(2R,5S)-3-(acetylamino)-2,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl]oxy}propanoyl]amino}propanoyl]amino}-5-amino-5-oxopentanoic acid (non-preferred name)
• 2: PN: WO2009039971 PAGE: 99 claimed protein
• <span class="text-smallcaps">D</smallcap>-α-Glutamine, N-(N-acetylmuramoyl)-<smallcap>L</span>-alanyl-
• <span class="text-smallcaps">D</smallcap>-α-Glutamine, N²-[N-(N-acetylmuramoyl)-<smallcap>L</span>-alanyl]-
• Acetylmuramoyl-<span class="text-smallcaps">L</smallcap>-alanyl-<smallcap>D</span>-isoglutamine
• Acetylmuramyl-L-alanyl-D-isoglutamine
• Acetylmuramyl-alanyl-isoglutamine
• Brn 4220745
• D-alpha-Glutamine, N(sup 2)-(N-(N-acetylmuramoyl)-L-alanyl)-
• D-alpha-Glutamine, N2-(N-(N-acetylmuramoyl)-L-alanyl)-
• D-α-Glutamine, N-(N-acetylmuramoyl)-L-alanyl-
• D-α-Glutamine, N2-[N-(N-acetylmuramoyl)-L-alanyl]-
• MDP
• MDP-<span class="text-smallcaps">D</span>
• Muramoyl dipeptide
• Muramyl dipeptide
• N(sup 2)-(N-(N-Acetylmuramoyl)-L-alanyl)-D-alpha-glutamine
• N-(Acetylmuramoyl)-<span class="text-smallcaps">L</smallcap>-alanyl-<smallcap>D</span>-isoglutamine
• N-(Acetylmuramoyl)alanyl-<span class="text-smallcaps">D</span>-isoglutamine
• N-(Acetylmuramoyl)alanyl-D-isoglutamine
• N-(N-Acetylmuramoyl)-<span class="text-smallcaps">L</smallcap>-alanyl-<smallcap>D</span>-α-glutamine
• N-Acetylmuramoyl dipeptide
• N-Acetylmuramoyl-<span class="text-smallcaps">L</smallcap>-alanine-<smallcap>D</span>-isoGln
• N-Acetylmuramoylalanyl-<span class="text-smallcaps">D</span>-isoglutamine
• N-Acetylmuramyl dipeptide
• N-Acetylmuramyl-L-Alanyl-D-Isoglutamine
• N-Acetylmuramyl-L-alanine-D-isoGln
• N2-(N-(N-Acetylmuramoyl)-L-alanyl)-D-alpha-glutamine
• N2-[N-(N-Acetylmuramoyl)-L-alanyl]-D-α-glutamin
• N2-[N-(N-acetilmuramoil)-L-alanil]-D-α-glutamina
• N-(N-Acetylmuramoyl)-L-alanyl-D-α-glutamine
• N-(Acetylmuramoyl)-L-alanyl-D-isoglutamine
• N-Acetylmuramoylalanyl-D-isoglutamine
• AC-MURAMYL-ALA-D-ISOGLUTAMINE
• n-acetylmuramyl-l-alanyl-d-isoglutamine hydrate
• AC-MURAMYL-ALA-D-GLN
• ADJUVANT PEPTIDE
• N-ACETYL-MURAMYL-L-ALA-D-ISOGLN
• n(sup2)-(n-(n-acetylmuramoyl)-l-alanyl)-d-alpha-glutamin
• N-AC-MURAMYL-ALA-D-GLU-NH2
• AC-MURAMYL-ALA-D-ISOGLN-OH
• L-18-MDP
• n(sup2)-(n-(n-acetylmuramoyl)-l-alanyl)-d-alpha-glutamine
• N-Acetylmuramyl-L-alanyl-D-isoglnamine hydrate
• AC-MURAMYL-ALA-D-GLU-NH2
• Adjuvant Peptide, Muramyl dipeptide
• N-AC-MURAMYL-ALA-D-GLU-NH2 2H2O

Ac-muramyl-Ala-D-Glu-NH₂

CAS: 53678-77-6

Muramyl dipeptide (MDP) inhibits HIV replication in CD4⁺ H9 lymphocytes..

Fórmula: C₁₉H₃₂N₄O₁₁

Pureza: 99.2%

Cor e Forma: White Powder

Peso molecular: 492.48

Ref: 01-4009623

Muramyl dipeptide

CAS: 53678-77-6

Muramyl dipeptide

Pureza: ≥98%

Peso molecular: 492.48g/mol

Ref: 54-BUP02131

PAF (Platelet-Activating Factor, bovine heart)

CAS: 53678-77-6

Fórmula: C19H32N4O11

Pureza: 95%

Cor e Forma: In solution, Chloroform

Peso molecular: 492.48

Ref: 48-39-0300

Muramyl dipeptide

CAS: 53678-77-6

MDP is a synthetic peptide promoting bone formation by modulating osteoclasts, osteoblasts, and Runx2 expression via MAPK pathways.

Fórmula: C₁₉H₃₂N₄O₁₁

Pureza: 99.34%

Cor e Forma: Solid

Peso molecular: 492.48

Ref: TM-T16159

N-Acetylmuramyl-L-alanyl-D-isoglutamine hydrate

CAS: 53678-77-6

Muramyl dipeptide is a component of the bacterial cell wall and is found in mycobacteria, mycoplasmas, spirochetes, and gram-positive bacteria. Muramyl dipeptide has been shown to induce the activation of macrophages and other cells by stimulating toll-like receptor 4. It also has significant cytotoxicity against various cancer cells, as well as potent inducers of ubiquitin ligases. The use of muramyl dipeptide in vitro was shown to inhibit replication of HIV-1 virus in human lymphocytes. This agent has also been used for the treatment of bowel disease.

Fórmula: C₁₉H₃₂N₄O₁₁·xH₂O

Pureza: Min. 96 Area-%

Cor e Forma: Powder

Peso molecular: 492.48 g/mol

Ref: 3D-MA58738

Adjuvant Peptide

CAS: 53678-77-6

Adjuvant Peptide is a glycol ether that has been shown to have biological properties. It is used in the production of Immunoassays and other biochemicals. Adjuvant Peptide is an experimental model for immunity, as it stimulates cellular responses and alters the immune system's response to antigens. It shows potential for use in treating bowel diseases, such as ulcerative colitis, because of its ability to stimulate macrophage activity and induce cytokine production.

Fórmula: C₁₉H₃₂N₄O₁₁•2H₂O

Pureza: Min. 95%

Peso molecular: 528.51 g/mol

Ref: 3D-PAD-4031

Adjuvant Peptide

CAS: 53678-77-6

Adjuvant peptide is a research tool that can be used in the study of protein interactions, pharmacology and cell biology. It can also be used as an inhibitor for ion channels or receptors. Adjuvant peptide has a molecular weight of 638.2 Da and a purity of > 98%.

Fórmula: C₁₉H₃₂N₄O₁₁

Pureza: Min. 95%

Peso molecular: 492.48 g/mol

Ref: 3D-PAD-4031-V

N-ACETYLMURAMYL-L-ALANYL-D-ISOGLUTAMINE

CAS: 53678-77-6

Fórmula: C₁₉H₃₂N₄O₁₁

Pureza: 98%

Peso molecular: 492.4776

Ref: IN-DA00DABS