CAS 54-05-7

Cloroquina

Descrição:

Cloroquina é um composto sintético conhecido principalmente por seu uso como medicamento antimalárico. Pertence à classe das 4-aminoquinolinas e é caracterizado por sua capacidade de interferir no crescimento de parasitas nas células vermelhas do sangue. A fórmula química de Cloroquina é C18H26ClN3, e possui um peso molecular de aproximadamente 319,87 g/mol. Cloroquina é tipicamente apresentado como um pó cristalino branco a off-white que é solúvel em água e exibe um sabor amargo. Seu mecanismo de ação envolve a inibição da polimerização de heme dentro do parasita da malária, levando a uma acumulação tóxica de heme. Além de suas propriedades antimaláricas, Cloroquina também foi investigado por potenciais efeitos antivirais e como um agente anti-inflamatório em condições como artrite reumatoide e lúpus. No entanto, seu uso tem sido associado a vários efeitos colaterais, incluindo distúrbios gastrointestinais e toxicidade retiniana com uso a longo prazo. Devido ao surgimento de cepas de malária resistentes a medicamentos, a eficácia de Cloroquina diminuiu em algumas regiões, levando à exploração de tratamentos alternativos.

Fórmula: C₁₈H₂₆ClN₃

InChI: InChI=1/C18H26ClN3/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21)/t14-/m0/s1

Chave InChI: InChIKey=WHTVZRBIWZFKQO-UHFFFAOYSA-N

SMILES: N(C(CCCN(CC)CC)C)C=1C2=C(N=CC1)C=C(Cl)C=C2

Sinónimos:

• (4S)-N~4~-(7-chloroquinolin-4-yl)-N~1~,N~1~-diethylpentane-1,4-diamine
• 1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-
• 1,4-Pentanediamine, N⁴-(7-chloro-4-quinolinyl)-N¹,N¹-diethyl-
• 4-(7-Chloro-4-Quinolylamino)Pentyldiethylamine
• 7-Chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]quinoline
• Aralen
• Artrichin
• Bipiquin
• Capquin
• Chloraquine
• Chloro Quine Phosphate
• Chlorochin
• Chlorolex
• Chloroquin
• Cloquin
• Cloroquina
• E-Vivax
• Maliago
• N⁴-(7-Chloro-4-quinolinyl)-N¹,N¹-diethyl-1,4-pentanediamine
• Nivaquinp
• Nsc 187208
• Premoquine
• Quinoline, 7-chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]-
• Reumachlor
• Ronaquine
• Rp 3377
• ST 121 (pharmaceutical)
• St 121
• N4-(7-Chloro-4-quinolinyl)-N1,N1-diethyl-1,4-pentanediamine
• Quinagamin
• Chlorquin
• Chloroquina
• 3377 RP
• Cocartrit
• Avlochlor
• Arthrochin
• Imagon
• Sopaquin
• Chingamin
• 7-chloro-4-(4-diethylamino-1-methylbutylamino)quinoline
• WIN 244
• Bemaphate
• Quinachlor
• Nivaquine B
• -[7-Chloro-4-quinolinyl]-N',N'-diethyl-1,4-pentanediamine
• Lapaquin
• SN 6718
• Cidanchin
• Quinoscan
• 7-CHLORO-4-(4-DIMETHYLAMINO-1-METHYLBUTYLAMINO)QUINOLINE
• Delagil
• Diphenylhydramine
• Nivaquine
• Bemasulph
• Elestol
• w7618
• 7-chloro-4-((4-(diethylamino)-1-methylbutyl)amino)-quinolin
• n(4)-(7-chloro-4-quinolinyl)-n(1),n(1)-diethyl-4-pentanediamine
• Resoquine
• Tanakan
• nivaquineb
• Arechin
• SN 7618
• Benaquin
• W 7618
• Mesylith
• Silbesan
• Sanoquin
• Quinercyl
• N(sup4)-(7-chloro-4-quinolinyl)-N(sup1),N(sup1)-diethyl-1,4-pentanediamine
• Avloclor
• 4-(4-Diethylamino-1-methylbutylamino)-7-chloroquinoline
• Clorochina
• CHLOROQUINE
• 3377 RP opalate
• 4-(4-Diethylamino-1-methylbntyla-mino)-7-chloroquinoline
• Nivaquine [as sulfate]
• N
• Reumaquin
• Tresochin
• Malaquin
• 4
• Neochin
• Malarex
• Dichinalex
• Chloroquine (base and/or unspecified salts)
• Resochin
• Quingamine
• (7-chloro-4-(4-diethylamino-1-methylbutylamino)-quinoline
• win244
• Cloroquine
• Nivachine
• Amokin
• Resochen
• rp3377
• Quinagamine
• Chemochin
• Gontochin
• 1,4-pentanediamine,n(sup4)-(7-chloro-4-quinolinyl)-n(sup1),n(sup1)-diethy
• Solprina
• sn7618
• Siragan
• Trochin
• Resoquina
• Malaren
• Chloroquinium
• N4-(7-chloroquinolin-4-yl)-N1,N1-diethylpentane-1,4-diaMine
• Bemaco
• Heliopar
• Klorokin
• Roquine
• Iroquine
• Pfizerquine
• Chlorochine

Chloroquine

CAS: 54-05-7

Fórmula: C₁₈H₂₆ClN₃

Pureza: 97%

Cor e Forma: Solid

Peso molecular: 319.8721

Ref: IN-DA00DDVD

N4-(7-Chloroquinolin-4-Yl)-N1,N1-Diethylpentane-1,4-Diamine

CAS: 54-05-7

N4-(7-Chloroquinolin-4-Yl)-N1,N1-Diethylpentane-1,4-Diamine

Pureza: 97%

Peso molecular: 319.87g/mol

Ref: 54-OR1014213

Chloroquine

CAS: 54-05-7

Chloroquine

Pureza: ≥95%

Peso molecular: 319.87g/mol

Ref: 54-BUP17107

Chloroquine

CAS: 54-05-7

Fórmula: C₁₈H₂₆ClN₃

Pureza: >98.0%(T)(HPLC)

Cor e Forma: White to Light yellow powder to lump

Peso molecular: 319.88

Ref: 3B-C3730

Chloroquine

CAS: 54-05-7

Chloroquine: antimalarial, anti-inflammatory, autophagy/TLRs inhibitor, treats arthritis, effective against COVID-19 in vitro. EC50: 1.13 μM.

Fórmula: C₁₈H₂₆ClN₃

Pureza: 99.5% - 99.98%

Cor e Forma: White To Slightly Yellow Crystalline Powder Solid

Peso molecular: 319.87

Ref: TM-T8689

Chloroquine

CAS: 54-05-7

Applications Chloroquine used in the treatment of malaria and MDR-strains. It is a COVID19-related research product.
References Laufer, M. et al.: PLoS One., 7, e42284 (2012); Hangartner, S. et al.: Drug Test. ANal., 5, 777 (2013)

Fórmula: C₁₈H₂₆ClN₃

Cor e Forma: White To Light Brown

Peso molecular: 319.87

Ref: TR-C380318

Chloroquine

CAS: 54-05-7

Chloroquine is a 4-aminoquinolone that is used to prevent and treat malaria, caused by parasitic protozoan from the Plasmodium genus. Chloroquine is are an schizonticidal agent and is a widely prescribed antimalarial compound. The antiviral activity of chloroquine in vitro has been reported in 1960’s and recent publications have brought attention to its possible benefits in the treatment of COVID-19 patients, infected with the newly emerged coronavirus (SARS-CoV-2). Current evidence shows that chloroquine inhibits SARS CoV-2 entry in host cells by interfering with endocytosis and the glycoprofile on the S-glycoprotein.

Fórmula: C₁₈H₂₆ClN₃

Pureza: Min. 95%

Cor e Forma: White Off-White Powder

Peso molecular: 319.87 g/mol

Ref: 3D-FC150960

N4-(7-Chloroquinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine

CAS: 54-05-7

Fórmula: C₁₈H₂₆ClN₃

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 319.88

Ref: 10-F242503