CAS 54-62-6

Aminopterina

Descrição:

Aminopterina é um antagonista do folato e um membro da classe de compostos Aminopterina, conhecido principalmente por seu papel como antimetabólito na terapia do câncer e como agente imunossupressor. É um pó cristalino branco a amarelo pálido que é solúvel em água e apresenta um perfil de solubilidade dependente do pH. A estrutura química de Aminopterina apresenta um anel de pteridina, que é essencial para sua atividade biológica, e inibe a enzima diidrofolato redutase, interferindo assim na síntese de DNA e na proliferação celular. Esse mecanismo o torna eficaz no tratamento de certos tipos de leucemia e outras malignidades. Além disso, Aminopterina tem sido utilizado em ambientes de pesquisa para estudar o metabolismo do folato e suas implicações em vários processos biológicos. No entanto, seu uso está associado a efeitos colaterais significativos, incluindo supressão da medula óssea e distúrbios gastrointestinais, exigindo monitoramento cuidadoso durante o tratamento. Devido a essas características, Aminopterina é um composto crítico tanto em aplicações clínicas quanto em pesquisas no campo da química medicinal.

Fórmula: C₁₉H₂₀N₈O₅

InChI: InChI=1S/C19H20N8O5/c20-15-14-16(27-19(21)26-15)23-8-11(24-14)7-22-10-3-1-9(2-4-10)17(30)25-12(18(31)32)5-6-13(28)29/h1-4,8,12,22H,5-7H2,(H,25,30)(H,28,29)(H,31,32)(H4,20,21,23,26,27)/t12-/m0/s1

Chave InChI: InChIKey=TVZGACDUOSZQKY-LBPRGKRZSA-N

SMILES: NC=1C2=C(N=CC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)N=C(N)N1

Sinónimos:

• (2S)-2-[[4-[(2,4-Diaminopteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
• 4-Amino-4-Deoxypteroylglutamate
• 4-Amino-Folicaci
• 4-Amino-Pga[Qr]
• 4-Aminofolic Acid
• 4-Aminofolicacid[Qr]
• 4-Aminopteroylglutamic acid
• 4-Aminopteroylglutamicacid[Qr]
• 4-Diamino-6-Pteridinyl)Methyl)Amino)Benzoyl)-N-(P-(((L-Glutamicaci
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-
• Acide N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamique
• Agpa
• Ai3-26079[Qr]
• Aminopterin
• Aminopterine
• Apga
• Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-, <span class="text-smallcaps">L</span>-
• Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-, L-
• L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-
• N-(4-{[(2,4-diaminopteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
• N-(4-{[(2,4-diaminopteridin-6-yl)methyl]amino}benzoyl)glutamic acid
• N-[(4-{[(2,4-diaminopteridin-6-yl)methyl]amino}phenyl)carbonyl]-D-glutamic acid
• N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-<span class="text-smallcaps">L</span>-glutamic acid
• N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutaminsaure
• N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
• Nsc 739
• Pteramina
• Pteridin-2-Amine

Aminopterin

CAS: 54-62-6

Fórmula: C₁₉H₂₀N₈O₅

Pureza: >97.0%(T)(HPLC)

Cor e Forma: White to Amber powder to crystal

Peso molecular: 440.42

Ref: 3B-A0410

Methotrexate Related Compound B ((S)-2-{4-[(2,4-diaminopteridin-6-yl)methylamino]benzamido}pentanedioic acid)

CAS: 54-62-6

Compounds containing a pyrimidine ring, whether or not hydrogenated, or piperazine ring in the structure, nesoi

Fórmula: C₁₉H₂₀N₈O₅

Cor e Forma: White Yellow Powder

Peso molecular: 440.41

Ref: 45-1414025

Aminopterin dihydrate

CAS: 54-62-6

Fórmula: C₁₉H₂₀N₈O₅·xH₂O

Pureza: ≥ 97.0%

Cor e Forma: Pale yellow to yellow-brown powder

Peso molecular: 440.41 (anhydrous)

Ref: 7W-GK2974

Aminopterin

CAS: 54-62-6

Aminopterin

Pureza: ≥95%

Peso molecular: 440.41g/mol

Ref: 54-BUP06495

(2S)-2-[[4-[[(2,4-Diaminopteridin-6-yl)methyl]amino]benzoyl]amino]pentanedioic Acid (4-Aminofolic Acid, Aminopterin)

Produto Controlado

CAS: 54-62-6

Fórmula: C₁₉H₂₀N₈O₅

Cor e Forma: Neat

Peso molecular: 440.41

Ref: 86-MM0040.05

Aminopterin

CAS: 54-62-6

Pureza: 98%

Peso molecular: 440.420013427734

Ref: 10-F600196

Aminopterin

CAS: 54-62-6

Aminopterin (4-Aminofolic acid) is a synthetic folic acid derivative whose metabolite is a competitive inhibitor of dihydrofolate reductase

Fórmula: C₁₉H₂₀N₈O₅

Pureza: ≥98%

Cor e Forma: Orange-Yellow Powder Rodenticide In The U S (Epa 1998)

Peso molecular: 440.41

Ref: TM-T7730

Methotrexate EP Impurity B (Methotrexate USP Related Compound B)

CAS: 54-62-6

Fórmula: C₁₉H₂₀N₈O₅

Peso molecular: 440.42

Ref: 4Z-M-703

Methotrexate EP Impurity B

CAS: 54-62-6

Fórmula: C₁₉H₂₀N₈O₅

Peso molecular: 440.42

Ref: ST-EA-CP-M12002

Aminopterin

CAS: 54-62-6

Impurity Methotrexate EP Impurity B
Applications Aminopterin (Methotrexate EP Impurity B) is a folic acid antagonist. Its actively transported into cells by thefolate transporter. In the cell, its converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase, that, in turn, binds to dihydrofolate reductase and inhibits its activity.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Matherly, L.H., et al.: Cancer Res., 45, 1073 (1985), Rumberger, B.G., et al.: Cancer Res., 50, 4639 (1990), Roy, K., et al.: J. Biol. Chem., 273, 2526 (1998),

Fórmula: C₁₉H₂₀N₈O₅

Cor e Forma: Yellow

Peso molecular: 440.41

Ref: TR-A628850

Aminopterin

CAS: 54-62-6

Aminopterin is an antineoplastic agent and antifolate, which is a synthetic derivative of pteroylglutamic acid. It functions as a chemotherapeutic agent by inhibiting dihydrofolate reductase, an enzyme crucial in the folic acid pathway, thereby preventing the conversion of dihydrofolate to tetrahydrofolate. This disruption leads to impaired synthesis of purine nucleotides and thymidylate, which are essential for DNA synthesis and cell division.

Fórmula: C₁₉H₂₀N₈O₅

Pureza: Min. 97 Area-%

Cor e Forma: Slightly Yellow Powder

Peso molecular: 440.41 g/mol

Ref: 3D-FA17838

L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-

CAS: 54-62-6

Fórmula: C₁₉H₂₀N₈O₅

Cor e Forma: Solid

Peso molecular: 440.4127

Ref: IN-DA00I9N1