CAS: 548472-68-0 - Nutlin 3

Fórmula: C₃₀H₃₀Cl₂N₄O₄

InChI: InChI=1/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/s2

Chave InChI: InChIKey=BDUHCSBCVGXTJM-YBFHJACQNA-N

SMILES: O=C1NCCN(C(=O)N2C(=NC(C3=CC=C(Cl)C=C3)C2C4=CC=C(Cl)C=C4)C=5C=CC(OC)=CC5OC(C)C)C1

Sinónimos:

• 2-Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-, rel-
• 2-piperazinone, 4-[[4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-
• N 6287
• Nutlin 3
• Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-, rel-
• cis-4-[[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazole-1-yl]carbonyl]piperazin-2-one
• rel-4-[[(4R,5S)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone

Nutlin-3

CAS: 548472-68-0

• Fórmula: C₃₀H₃₀Cl₂N₄O₄
• Pureza: ≥ 97.0%
• Cor e Forma: White to off-white powder
• Peso molecular: 581.49

Nutlin-3

CAS: 548472-68-0

• Fórmula: C₃₀H₃₀Cl₂N₄O₄
• Pureza: >95.0%(HPLC)
• Cor e Forma: White to Light yellow powder to crystal
• Peso molecular: 581.49

Nutlin-3

CAS: 548472-68-0

Nutlin-3 is an MDM2 antagonist that inhibits MDM2-p53 interaction and activates p53. Nutlin-3 has antitumor …

• Fórmula: C₃₀H₃₀Cl₂N₄O₄
• Pureza: 98.27% - 99.89%
• Cor e Forma: Solid
• Peso molecular: 581.49

Nutlin 3A

CAS: 548472-68-0

Antagonist of proto-oncogene MDM2 and its interaction with p53

• Fórmula: C₃₀H₃₀Cl₂N₄O₄
• Pureza: Min. 95%
• Peso molecular: 581.49 g/mol

(+/-)-Nutlin-3

CAS: 548472-68-0

Applications (+/-)-Nutlin-3 is a small molecule MDM2 antagonist. References Vassilev, L.T., et. al.: Sci., 303, …

• Fórmula: C₃₀H₃₀Cl₂N₂O₄
• Cor e Forma: Neat
• Peso molecular: 580.5