CAS 5508-58-7

Andrografolídeo

Descrição:

Andrografolídeo é um composto natural derivado principalmente da planta Andrographis paniculata, comumente conhecida como o "rei dos amargos". É uma lactona diterpenoide bicíclica caracterizada pelo seu sabor amargo e é conhecida por suas diversas propriedades farmacológicas. A fórmula molecular de Andrografolídeo é C20H30O5, e tem um peso molecular de aproximadamente 350,46 g/mol. Este composto exibe uma gama de atividades biológicas, incluindo efeitos anti-inflamatórios, antioxidantes, antimicrobianos e antivirais, tornando-o de interesse na medicina tradicional e na farmacologia moderna. Andrografolídeo tem sido estudado por suas potenciais aplicações terapêuticas no tratamento de condições como infecções respiratórias, diabetes e câncer. Seu mecanismo de ação geralmente envolve a modulação de várias vias de sinalização e respostas imunológicas. Além disso, é relativamente estável em condições padrão, mas pode sofrer degradação quando exposto a pH ou temperatura extremos. No geral, Andrografolídeo representa uma área significativa de pesquisa devido às suas diversas atividades biológicas e potenciais benefícios à saúde.

Fórmula: C₂₀H₃₀O₅

InChI: InChI=1S/C20H30O5/c1-12-4-7-16-19(2,9-8-17(23)20(16,3)11-21)14(12)6-5-13-15(22)10-25-18(13)24/h5,14-17,21-23H,1,4,6-11H2,2-3H3/b13-5+/t14-,15-,16+,17-,19+,20+/m1/s1

Chave InChI: InChIKey=BOJKULTULYSRAS-OTESTREVSA-N

SMILES: C[C@]12[C@@]([C@@](CO)(C)[C@H](O)CC1)(CCC(=C)[C@H]2C/C=C/3\[C@H](O)COC3=O)[H]

Sinónimos:

• (2R,5S,10R,12E,14S)-2,14,17-trihydroxy-20-oxo-9,19-didehydro-5,6,7,8,9,10,11,14,15-decahydro-20:5,10-dicycloretinal
• (2R,5S,6S,10R,12E,14S)-2,14,17-trihydroxy-20-oxo-9,19-didehydro-5,6,7,8,9,10,11,14,15-decahydro-20:5,10-dicycloretinal
• (3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-2(3H)-furanone
• (5S,10R,12E)-2,14,16-trihydroxy-20-oxo-9,19-didehydro-5,6,7,8,9,10,11,14,15-decahydro-20:5,10-dicycloretinal
• 2(3H)-Furanone, 3-(2-(decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl)ethylidene)dihydro-4-hydroxy-, (1R-(1-alpha(E(S*)),4a-beta,5-alpha,6-alpha,8a-alpha))-
• 2(3H)-Furanone, 3-[2-[(1R,4aS,5R,6R,8aS)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-, (3E,4S)-
• 2(3H)-Furanone, 3-[2-[decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-, [1R-[1α[E(S*)],4aβ,5α,6α,8aα]]-
• 3-(2-(Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenenaphthyl)ethylidene)dihydro-4-hydroxyfuran-2(3H)-one
• 3-Dehydroandrographolide Or 19-Dehydroandrographolide? P. 1388
• 3-[2-[Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylennaphthyl]ethyliden]dihydro-4-hydroxyfuran-2(3H)-on
• 3-[2-[decahidro-6-hidroxi-5-(hidroximetil)-5,8a-dimetil-2-metilennaftil]etiliden]dihidro-4-hidroxifuran-2(3H)-ona
• 3-[2-[decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenenaphtyl]ethylidene]dihydro-4-hydroxyfuranne-2(3H)-one
• 4-hydroxy-3-{2-[6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidenedecahydronaphthalen-1-yl]ethylidene}dihydrofuran-2(3H)-one
• 5β,9β<span class="text-smallcaps">H</span>,10α-Labda-8(20),12-dien-16-oic acid, 3α,14,15,18-tetrahydroxy-, γ-lactone
• 5β,9βH,10α-Labda-8(20),12-dien-16-oic acid, 3α,14,15,18-tetrahydroxy-, γ-lactone
• Andrographis
• Andrographiside aglycon
• Andrographolid
• Andrographolide,14-Deoxy 11,12-Didehydro
• Nsc 383468

Andrographolide

CAS: 5508-58-7

Fórmula: C₂₀H₃₀O₅

Pureza: >98.0%(HPLC)

Cor e Forma: White to Light yellow powder to crystal

Peso molecular: 350.46

Ref: 3B-A2459

Andrographolide

CAS: 5508-58-7

Andrographolide analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

Fórmula: C₂₀H₃₀O₅

Pureza: (HPLC) ≥95%

Cor e Forma: Powder

Peso molecular: 350.46

Ref: 11-3721

ANDROGRAPHOLIDE CRS

CAS: 5508-58-7

ANDROGRAPHOLIDE CRS

Fórmula: C₂₀H₃₀O₅

Peso molecular: 350.4492

Ref: 41-Y0001866

Andrographolide

CAS: 5508-58-7

Lactones, nesoi

Fórmula: C₂₀H₃₀O₅

Cor e Forma: White Crystalline Powder

Peso molecular: 350.20932

Ref: 45-1034862

(3E,4S)-3-{2-[(1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-decahydronaphthalen-1-yl]ethylidene}-4-hydroxyoxolan-2-one

CAS: 5508-58-7

Fórmula: C₂₀H₃₀O₅

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 350.4492

Ref: IN-DA003NW7

Andrographolide

CAS: 5508-58-7

Andrographolide

Pureza: 98%

Peso molecular: 350.45g/mol

Ref: 54-OR1029051

Andrographolide

CAS: 5508-58-7

Fórmula: C₂₀H₃₀O₅

Pureza: ≥ 98.0%

Cor e Forma: White to off-white powder

Peso molecular: 350.45

Ref: 7W-GP9833

Andrographolide

CAS: 5508-58-7

Andrographolide

Pureza: ≥98%

Peso molecular: 350.45g/mol

Ref: 54-BUP16789

Andrographolide

CAS: 5508-58-7

Fórmula: C₂₀H₃₀O₅

Pureza: 95%~99%

Peso molecular: 350.455

Ref: BP-BP0164

Andrographolide

CAS: 5508-58-7

Andrographolide (Andrographis)(Andrographis), an irreversible antagonist of NF-κB, has anti-inflammatory and anti-platelet aggregation activities and potential

Fórmula: C₂₀H₃₀O₅

Pureza: 99.39% - 99.97%

Cor e Forma: Powder

Peso molecular: 350.45

Ref: TM-T2898

Andrographolide

CAS: 5508-58-7

Lactone

Fórmula: C₂₀H₃₀O₅

Pureza: ≥ 98.0 % (HPLC)

Cor e Forma: Powder

Peso molecular: 350.46

Ref: 5G-89561

Andrographolide

Produto Controlado

CAS: 5508-58-7

Applications Andrographolide is a labdane diterpenoid (2). Andrographolide is the main bioactive component isolated from the medicinal plant Andrographis paniculata (2). Andrographolide showed significant antihepatotoxic action in P. berghei K173-induced hepatic damage in M. natalensis(1). Andrographolide inhibits tumor necrosis factor-α (TNF-α)-induced intercellular adhesion mol.-1 (ICAM-1) expression and adhesion of HL-60 cells onto human umbilical vein endothelial cells (HUVEC), which are associated with inflammatory diseases (2). These findings suggest that Andrographolide may have potential as a cardiovascular-protective agent.
References (1) Chander, R. et al.: Int. J. Pharmacog. (1995) 33, 135-8 (2) Chen, H.-W. et al.: J. Nat. Prod. (2011) 74, 2408-13

Fórmula: C₂₀H₃₀O₅

Cor e Forma: Neat

Peso molecular: 350.45

Ref: TR-A637475

Andrographolide

CAS: 5508-58-7

Andrographolide is a labdane diterpenoid, which is the primary active constituent extracted from the plant *Andrographis paniculata*. This compound exhibits a broad spectrum of pharmacological activities, primarily attributed to its ability to modulate various biological pathways. The mode of action of andrographolide includes the inhibition of pro-inflammatory cytokines and enzymes, as well as the activation of pathways that enhance antioxidant activities within cells.

Fórmula: C₂₀H₃₀O₅

Pureza: Min. 97.5 Area-%

Cor e Forma: White Powder

Peso molecular: 350.45 g/mol

Ref: 3D-FA17902

Andrographolide

CAS: 5508-58-7

Fórmula: C₂₀H₃₀O₅

Pureza: 95.0%

Cor e Forma: Solid, Crystalline Powder

Peso molecular: 350.455

Ref: 10-F078895