CAS 5536-17-4

Vidarabina

Descrição:

Vidarabina, também conhecido como arabinosídeo de adenina, é um análogo de nucleosídeo antiviral usado principalmente no tratamento de infecções virais, particularmente o vírus herpes simplex e o vírus varicela-zóster. É caracterizado por sua estrutura, que inclui um grupo de açúcar arabinose ligado a uma base de adenina, distinguindo-o dos nucleosídeos naturais. Vidarabina exibe sua atividade antiviral inibindo a síntese de DNA viral, evitando assim a replicação do vírus. O composto é tipicamente administrado por via intravenosa devido à sua baixa biodisponibilidade oral. Tem uma meia-vida relativamente curta, exigindo dosagem e monitoramento cuidadosos durante o tratamento. Vidarabina pode causar efeitos colaterais, incluindo neurotoxicidade e problemas hematológicos, que requerem consideração em ambientes clínicos. Seu uso diminuiu com o advento de agentes antivirais mais eficazes, mas continua sendo um composto significativo no estudo de terapias antivirais. Como entidade química, Vidarabina é classificado na categoria de nucleosídeos de purina e possui um número CAS específico, 5536-17-4, que é usado para sua identificação em bancos de dados químicos.

Fórmula: C₁₀H₁₃N₅O₄

InChI: InChI=1/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(16)1-19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7+,10-/m1/s1

Chave InChI: InChIKey=OIRDTQYFTABQOQ-UHTZMRCNSA-N

SMILES: O[C@@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](CO)[C@H]1O

Sinónimos:

• 6-Amino-9-beta-D-arabinofuranosylpurine
• 6-Amino-9-β-<span class="text-smallcaps">D</span>-arabinofuranosylpurine
• 6-Amino-9-β-D-arabinofuranosylpurine
• 9-(beta-D-Arabinofuranosyl)-9H-purin-6-amine
• 9-(beta-D-glycero-Pentofuranosyl)-9H-purin-6-amine
• 9-Arabinosyladenine
• 9-beta-D-Arabinofuranosyladenine
• 9-β-<span class="text-smallcaps">D</span>-Arabinoadenosine
• 9-β-<span class="text-smallcaps">D</span>-Arabinofuranosyl-9H-purin-6-amine
• 9-β-<span class="text-smallcaps">D</span>-Arabinofuranosyladenine
• 9-β-<span class="text-smallcaps">D</span>-Arabinosyladenine
• 9-β-D-Arabinoadenosine
• 9-β-D-Arabinofuranosyl-9H-purin-6-amine
• 9-β-D-Arabinofuranosyl-adenine
• 9-β-D-Arabinofuranosyladenine
• 9-β-D-Arabinosyladenine
• 9-β-D-arabinopyranosyl-9H-purin-6-amine
• 9H-Purin-6-amine, 9-beta-D-arabinofuranosyl-
• 9H-Purin-6-amine, 9-β-<span class="text-smallcaps">D</span>-arabinofuranosyl-
• 9H-Purin-6-amine, 9-β-D-arabinofuranosyl-
• 9H-purin-6-amine, 9-beta-D-glycero-pentofuranosyl-
• Adenine 9-β-<span class="text-smallcaps">D</span>-arabinofuranoside
• Adenine 9-β-D-arabinofuranoside
• Adenine arabinoside
• Adenine β-<span class="text-smallcaps">D</span>-arabinofuranoside
• Adenine β-D-arabinofuranoside
• Adenine, 9-beta-D-arabinofuranosyl-
• Adenine, 9-β-<span class="text-smallcaps">D</span>-arabinofuranosyl-
• Adenine, 9-β-D-arabinofuranosyl-
• Ara-A
• Araadenosine
• Arabinosyladenine
• Arasena-A
• Ci-673
• Nqz-071
• Nsc 247519
• Nsc 404241
• Spongoadenosine
• Vidarabin
• Vidarabina
• Vidarabine anhydrous
• Vira-A
• β-<span class="text-smallcaps">D</span>-Arabinofuranosyladenine
• β-<span class="text-smallcaps">D</span>-Arabinosyladenine
• β-Ara-A
• β-D-Arabinofuranosyladenine
• β-D-Arabinosyladenine
• beta-d-arabinosyladenine
• ADENINE-BETA-D-ARABINOFURANOSIDE
• 9-beta-d-arabinofuranosyl-adenin
• 9-beta-d-arabinofuranosyl-9h-purin-6-amin
• VIDARABINE
• adeninearabinoside
• beta-ara-a
• ci673
• ADENINE-9-BETA-D-ARABINOFURANOSIDE
• ARABINOSYL-ADENINE
• 2'-ARAADENOSINE

Vidarabine

CAS: 5536-17-4

Fórmula: C₁₀H₁₃N₅O₄

Pureza: >98.0%(T)(HPLC)

Cor e Forma: White to Light yellow powder to crystal

Peso molecular: 267.25

Ref: 3B-V0175

Vidarabine Monohydrate

CAS: 24356-66-9, 5536-17-4

Fórmula: C₁₀H₁₃N₅O₄·H₂O

Pureza: >98.0%(T)(HPLC)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 285.27

Ref: 3B-V0098

9-β-D-Arabinofuranosyladenine, 99%

CAS: 5536-17-4

Vidarabine is a neurotransmitter that acts as the preferred endogenous agonist at all adenosine receptor subtypes. Vidarabine is an inhibitor of A cyclase and DNA Polymerase. Used to study the roles of AMP-activated protein kinase (AMPK) in cell signaling. Cell-permeable adenylate cyclase inhibitor;

Fórmula: C₁₀H₁₃N₅O₄

Pureza: 99%

Peso molecular: 267.24

Ref: 02-J65076

Vidarabine

CAS: 5536-17-4

Vidarabine is a nucleoside antibiotic from Streptomyces with antiviral properties, effective against herpes and other DNA viruses.

Fórmula: C₁₀H₁₃N₅O₄

Pureza: 99.85%

Cor e Forma: White To Off-White Crystalline Powder

Peso molecular: 267.24

Ref: TM-T1506

Adenine 9-β-D-arabinofuranoside

CAS: 5536-17-4

Fórmula: C₁₀H₁₃N₅O₄

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 267.2413

Ref: IN-DA0034FO

Adenine 9-β-D-arabinofuranoside

CAS: 5536-17-4

Adenine 9-β-D-arabinofuranoside

Pureza: 99%

Peso molecular: 267.24g/mol

Ref: 54-OR1012219

Vidarabine

CAS: 5536-17-4

Vidarabine

Pureza: ≥98%

Peso molecular: 267.24g/mol

Ref: 54-BUP14712

Adenine 9-β-D-arabinofuranoside

CAS: 5536-17-4

Fórmula: C₁₀H₁₃N₅O₄

Pureza: ≥ 99.0%

Cor e Forma: White to off-white powder

Peso molecular: 267.24

Ref: 7W-GA0167

9-(b-D-Arabinofuranosyl)adenine

CAS: 5536-17-4

9-(b-D-Arabinofuranosyl)adenine is a nucleoside that is used as an antiviral agent. It binds to viral RNA and inhibits viral replication. 9-(b-D-Arabinofuranosyl)adenine has been shown to have potent side-effect profiles, including myocardial infarct, neuronal death, and immunological reactions. These effects are due to its ability to inhibit the synthesis of guanine nucleotides in the heart and brain cells, which are essential for energy production and neurotransmitter release respectively. 9-(b-D-Arabinofuranosyl)adenine also binds to toll-like receptors (TLRs), which are proteins found on the surface of cells that recognize invading microbes or foreign substances. This binding leads to activation of immune response pathways.

Fórmula: C₁₀H₁₃N₅O₄

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 267.24 g/mol

Ref: 3D-NA06007

(2R,3S,4S,5R)-2-(6-Amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

CAS: 5536-17-4

Fórmula: C₁₀H₁₃N₅O₄

Pureza: 95%

Cor e Forma: Crystalline Powder,Powder

Peso molecular: 267.245

Ref: 10-F091487

Vidarabine

Produto Controlado

CAS: 5536-17-4

Applications Vidarabine, is an antiviral drug which is active against herpes simplex and varicella zoster viruses.
References Sneader, W., et al.: Drug Discovery, 258 (2005); Lee, W. W., et al.: J. Am. Chem. Soc., 82, 2648 (1960);

Fórmula: C₁₀H₁₃N₅O₄

Cor e Forma: Neat

Peso molecular: 267.24

Ref: TR-V305030