CAS 56-75-7

(-)-Cloranfenicol

Descrição:

(-)-Cloranfenicol, com o número CAS 56-75-7, é um antibiótico de amplo espectro originalmente derivado da bactéria Streptomyces venezuelae. É caracterizado por sua capacidade de inibir a síntese de proteínas bacterianas ao se ligar à subunidade 50S do ribossomo bacteriano, bloqueando efetivamente a formação de ligações peptídicas. Este composto é um pó cristalino branco a off-white que é solúvel em água e álcool, mas tem solubilidade limitada em solventes orgânicos. Sua fórmula molecular é C11H12Cl2N2O5, e tem um peso molecular de aproximadamente 323,13 g/mol. (-)-Cloranfenicol exibe atividade antibacteriana contra uma ampla gama de bactérias Gram-positivas e Gram-negativas, tornando-o útil no tratamento de várias infecções. No entanto, seu uso é limitado devido a potenciais efeitos colaterais, incluindo anemia aplástica e síndrome do bebê cinza em recém-nascidos. Como resultado, muitas vezes é reservado para infecções graves onde outros antibióticos são ineficazes. O manuseio e a dosagem adequados são cruciais para minimizar os efeitos adversos e garantir a eficácia terapêutica.

Fórmula:C₁₁H₁₂Cl₂N₂O₅

InChI:InChI=1/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9?/m1/s1

Chave InChI:InChIKey=WIIZWVCIJKGZOK-RKDXNWHRSA-N

SMILES:[C@@H]([C@H](NC(C(Cl)Cl)=O)CO)(O)C1=CC=C(N(=O)=O)C=C1

Sinónimos:

2,2-Dichloro-N-(2-Hydroxy-1-(Hydroxymethyl)-2-(4-Nitrophenyl)Ethyl)-Acetamid
2,2-Dichloro-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide
2,2-Dichloro-N-[2-Hydroxy-1-(Hydroxymethyl)-2-(4-Nitrophenyl)Ethyl]Acetamide
2,2-dichloro-N-[(1R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide
2,2-dichloro-N-[(1R,2S)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide
2,2-dichloro-N-[(1S,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide
Ak-Chlor
Alficetyn
Amphenicol
Amphicol
Amseclor
Anacetin
Aquamycetin
Austracol
Bradyoxetin
CAF
CAM
CAP
CPh
Catilan
Chemicetin
Chemicetina
Chlomycol
Chloramex
Chloramphenicol
Chloramsaar
Chlorasol
Chlorcetin
Chloricol
Chlorocaps
Chlorocid
Chlorocide
Chlorocin
Chloromycetin
Chloronitrin
Chloroptic
Ciplamycetin
Cloramfen
Cloramfenicol
Cloramficin
Cloramicol
Clorocyn
Cloromisan
Cylphenicol
D-(-)-Chloramphenicol
D-(-)-Threo-2,2-Dichloro-N-[Beta-Hydroxy-Alpha-(Hydroxy-Methyl)-P-Nitrophenethyl]Acetamide
D-(-)-threo-1-(4-Nitrophenyl)-2-dichloroacetamido-1,3-propanediol
D-(-)-threo-1-p-Nitrophenyl-2-dichloracetamido-1,3-propanediol
D-(-)-threo-1-p-Nitrophenyl-2-dichloroacetylamino-1,3-propanediol
D-(-)-threo-2-Dichloroacetamido-1-p-nitrophenyl-1,3-propanediol
D-(-)-threo-Chloramphenicol
D-threo-(1R,2R)-1-p-Nitrophenyl-2-dichloroacetamido-1,3-propanediol
D-threo-N-Dichloroacetyl-1-p-nitrophenyl-2-amino-1,3-propanediol
Detreomycin
Embacetin
Enicol
Enteromycetin
Farmicetina
Fenicol
Globenicol
Gloveticol
Halcetin
Intramycetin
Ismicetina
Juvamycetin
Kamaver
Kemicetine
Klorita
Leukomyan
Leukomycin
Levocin
Levomicetina
Levomitsetin
Levomycetin
Levoplast
Levosin
Levovetin
Loromisin
Mastiphen
Micloretin
Micoclorina
Microcetina
Mychel
Mychel-Vet
Mycinol
Myclocin
Mycochlorin
Novomycetin
Ocuphenicol
Opclor
Ophthochlor
Pantovernil
Paraxin
Quemicetina
Ronphenil
Septicol
Sintomicetin
Sintomicetina
Soluthor
Stanomycetin
Synthomycetin
Synthomycin
Tevcocin
Tifomycine
Treomicetina
Unimycetin
Veticol
Viceton
[R-(R*,R*)]-2,2-Dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide
D,L-chloramphenicol
Acetamide, 2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-, [R-(R*,R*)]-
nitrophenyl)ethyl]acetamide
Acetamide, 2,2-dichloro-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-
Acetamide, 2,2-dichloro-N-[β-hydroxy-α-(hydroxymethyl)-p-nitrophenethyl]-, D-threo-(-)-
2,2-dichloro-N-[(1R)-2-hydroxy-1-(hydroxymethyl)-2-(4-
D-THREO-2,2-DICHLORO-N-[BETA-HYDROXY-ALPHA-(HYDROXYMETHYL)-4-NITROPHENETHYL]ACETAMIDE
D-THREO-(-)-2,2-DICHLORO-N-[BETA-HYDROXY-ALPHA-HYDROXYMETHYL-P-NITROPHENETHYL]ACETAMIDE
D-THREO-2,2-DICHLORO-N-[BETA-HYDROXY-ALPHA-(HYDROXYMETHYL)-4-NITROPHENYL] ACETAMIDE
D-THREO-2-DICHLOROACETAMIDO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL
D-2-DICHLOROACETAMIDO-1-P-NITRO-PHENYL-1,3-PROPANEDIOL
[R-(R*,R*)]-2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]ethanamide
D(-)-THREO-2,2-DICHLORO-N-[BETA-HYDROXY-ALPHA-(HYDROXYMETHYL)-BETA-(4-NITROPHENYL)ETHYL]ACETAMIDE
D(-)-THREO-2,2-DICHLORO-N-[BETA-HYDROXY-ALPHA-(HYDROXY-METHYL)-P-NITROPHENYLETHYL]ACETAMIDE
D-(-)-THREO-2-DICHLOROACETAMIDO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL
CHLORAMPHENICOLUM
D-(-)-THREO-2-DICHLOROACETAMIDO-1-[P-NITRO-PHENYL]-1,3-PROPANEDIOL
,[theta-(theta,theta)]-
D-THREO-2,2-DICHLORO-N-[BETA-HYDROXY-ALPHA(HYDROXYMETHYL)-BETA-(4-NITROPHENYL)ETHYL]ACETAMIDE
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