CAS 56377-79-8

Nosiheptida

Descrição:

Nosiheptida é um antibiótico peptídico cíclico que pertence à classe dos tiopeptídeos, conhecidos por suas características estruturais únicas e potentes atividades biológicas. É produzido por certas cepas da bactéria *Nocardia*, e sua estrutura inclui uma série de aminoácidos ligados por ligações peptídicas, frequentemente apresentando aminoácidos incomuns e um anel de tiazol ou oxazol. Nosiheptida exibe fortes propriedades antibacterianas, particularmente contra bactérias Gram-positivas, tornando-o de interesse no campo da química medicinal e desenvolvimento de antibióticos. Seu mecanismo de ação geralmente envolve a inibição da síntese de proteínas ao se ligar ao RNA ribossômico, interrompendo o processo de tradução. Além disso, devido à sua estrutura complexa, Nosiheptida tem sido estudado por suas potenciais aplicações no tratamento de infecções causadas por cepas resistentes a antibióticos. A pesquisa sobre suas propriedades farmacológicas, biossíntese e possíveis usos terapêuticos continua a ser uma área de investigação ativa, destacando a importância dos produtos naturais na descoberta de medicamentos.

Fórmula: C₅₁H₄₃N₁₃O₁₂S₆

InChI: InChI=1S/C51H43N13O12S6/c1-5-23-46-60-28(14-79-46)41(70)56-25-10-33(67)50(74)76-11-21-7-6-8-24-34(21)18(2)35(54-24)51(75)82-17-31(57-42(71)29-15-80-47(25)61-29)48-58-26(12-78-48)37-22(45-59-30(13-77-45)43(72)64-36(20(4)65)44(73)55-23)9-32(66)38(63-37)49-62-27(16-81-49)40(69)53-19(3)39(52)68/h5-9,12-16,20,25,31,33,36,54,65-67H,3,10-11,17H2,1-2,4H3,(H2,52,68)(H,53,69)(H,55,73)(H,56,70)(H,57,71)(H,64,72)

Chave InChI: InChIKey=OQAOHXRUMXWDLQ-UHFFFAOYSA-N

SMILES: OC=1C=C2C(C=3N=C(SC3)C4NC(=O)C=5N=C(SC5)C(NC(=O)C=6N=C(C(=CC)NC(=O)C(C(C)O)NC(=O)C=7N=C2SC7)SC6)CC(O)C(=O)OCC8=C9C(C)=C(C(=O)SC4)NC9=CC=C8)=NC1C%10=NC(C(NC(C(N)=O)=C)=O)=CS%10

Sinónimos:

• Multhiomycin
• 30,32-Imino-8,5:18,15:40,37-trinitrilo-21,36-([2,4]-endo-thiazolomethanimino)-5H,15H,37H-pyrido[3,2-w][2,11,21,27,31,7,14,17]benzoxatetrathiatriazacyclohexatriacontine, nosiheptide deriv.
• Nosiheptide
• N-[1-(Aminocarbonyl)ethenyl]-2-[(11S,14Z,21S,23S,29S)-14-ethylidene-9,10,11,12,13,14,19,20,21,22,23,24,26,33,35,36-hexadecahydro-3,23-dihydroxy-11-[(1R)-1-hydroxyethyl]-31-methyl-9,12,19,24,33,43-hexaoxo-30,32-imino-8,5:18,15:40,37-trinitrilo-21,36-([2,4]-endo-thiazolomethanimino)-5H,15H,37H-pyrido[3,2-w][2,11,21,27,31,7,14,17]benzoxatetrathiatriazacyclohexatriacontin-2-yl]-4-thiazolecarboxamide
• 4-Thiazolecarboxamide, N-[1-(aminocarbonyl)ethenyl]-2-[(11S,14Z,21S,23S,29S)-14-ethylidene-9,10,11,12,13,14,19,20,21,22,23,24,26,33,35,36-hexadecahydro-3,23-dihydroxy-11-[(1R)-1-hydroxyethyl]-31-methyl-9,12,19,24,33,43-hexaoxo-30,32-imino-8,5:18,15:40,37-trinitrilo-21,36-([2,4]-endo-thiazolomethanimino)-5H,15H,37H-pyrido[3,2-w][2,11,21,27,31,7,14,17]benzoxatetrathiatriazacyclohexatriacontin-2-yl]-

4-Thiazolecarboxamide,N-[1-(aminocarbonyl)ethenyl]-2-[(11S,14Z,21S,23S,29S)-14-ethylidene-9,10,11,12,13,14,19,20,21,22,23,24,26,33,35,36-hexadecahydro-3,23-dihydroxy-11-[(1R)-1-hydroxyethyl]-31-methyl-9,12,19,24,33,43-hexaoxo-30,32-imino-8,5:18,15:40,37-trinitrilo-21,36-([2,4]-endo-thiazolomethanimino)-5H,15H,37H-pyrido[3,2-w][2

CAS: 56377-79-8

Fórmula: C₅₁H₄₃N₁₃O₁₂S₆

Pureza: 96%

Cor e Forma: Solid

Peso molecular: 1222.3570

Ref: IN-DA01CBUM

Nosiheptide

CAS: 56377-79-8

Nosiheptide, a thiopeptide antibiotic from Streptomyces actuosus, boosts animal growth; it blocks protein synthesis in bacteria.

Fórmula: C₅₁H₄₃N₁₃O₁₂S₆

Pureza: 95.37%

Cor e Forma: Solid

Peso molecular: 1222.36

Ref: TM-T16340

Nosiheptide

CAS: 56377-79-8

Nosiheptide

Pureza: ≥95%

Peso molecular: 1222.36g/mol

Ref: 54-BUP05380

N-(3-Amino-3-Oxoprop-1-En-2-Yl)-2-((11S,14Z,21S,23S,29S)-14-Ethylidene-3,23-Dihydroxy-11-((1R)-(1-Hydroxyethyl))-31-Methyl-9,12,19,24,33,43-Hexaoxo-9,10,11,12,13,14,19,20,21,22,23,24,26,33,35,36-Hexad

CAS: 56377-79-8

N-(3-Amino-3-Oxoprop-1-En-2-Yl)-2-((11S,14Z,21S,23S,29S)-14-Ethylidene-3,23-Dihydroxy-11-((1R)-(1-Hydroxyethyl))-31-Methyl-9,12,19,24,33,43-Hexaoxo-9,10,11,12,13,14,19,20,21,22,23,24,26,33,35,36-Hexad

Pureza: 90%

Peso molecular: 1222.36g/mol

Ref: 54-OR1023930

Nosiheptide 100 µg/mL in Acetonitrile:Dimethylsulfoxide

CAS: 56377-79-8

Fórmula: C₅₁H₄₃N₁₃O₁₂S₆

Cor e Forma: Single Solution

Peso molecular: 1222.36

Ref: 04-A15652500DL-100

Nosiheptide (Standard)

CAS: 56377-79-8

Nosiheptide (Standard) is the standard substance of Nosiheptide, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Nosiheptide (Multhiomycin), a thiopeptide antibiotic synthesized by Streptomyces actuosus, serves as a potent feed additive to promote animal growth. It functions by hindering bacterial protein synthesis and is distinguished by an indole side ring system and regiospecific hydroxyl groups on its macrocyclic core.

Fórmula: C₅₁H₄₃N₁₃O₁₂S₆

Peso molecular: 1222.36

Ref: TM-TMSM-1776

Nosiheptide

CAS: 56377-79-8

Fórmula: C₅₁H₄₃N₁₃O₁₂S₆

Peso molecular: 1222.34

Ref: 4Z-PN-172001

Nosiheptide

CAS: 56377-79-8

A thiopeptide antibiotic produced by the bacterium Streptomyces actuosus. In addition, nosiheptide inhibits bacterial protein biosynthesis by acting during the elongation of the protein.

Fórmula: C₅₁H₄₃N₁₃O₁₂S₆

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 1,222.36 g/mol

Ref: 3D-FA76383

Nosiheptide (>85%)

CAS: 56377-79-8

Applications Nosiheptide is an antibacterial item used in feedstock and feed additives for chickens.
References Wang, H. et al.: J. Sci. Food. Agri., 93, 284 (2013); Kobayashi, I. et al.: Res. Dev. Rev., 2, 53 (1988);

Fórmula: C₅₁H₄₃N₁₃O₁₂S₆

Cor e Forma: Neat

Peso molecular: 1222.36

Ref: TR-N884000