CAS 564-36-3

Ergocornina

Descrição:

Ergocornina é um alcaloide que ocorre naturalmente e é derivado do fungo do ergot, especificamente da espécie Claviceps purpurea. Faz parte do grupo maior de alcaloides do ergot, que são conhecidos por suas estruturas complexas e diversas atividades biológicas. Ergocornina é caracterizado por sua estrutura tetracíclica, que inclui uma estrutura fundida de indole e isoquinolina. Este composto exibe várias propriedades farmacológicas, incluindo vasoconstrição e efeitos sobre sistemas de neurotransmissores, particularmente em relação à serotonina e dopamina. Ergocornina tem sido estudado por suas potenciais aplicações terapêuticas, incluindo seu papel no tratamento de enxaquecas e outros distúrbios vasculares. No entanto, também está associado a efeitos adversos, particularmente quando derivado de grãos contaminados, levando ao ergotismo. O composto é tipicamente encontrado em forma cristalina e é solúvel em solventes orgânicos. Suas propriedades químicas e atividades biológicas o tornam um assunto de interesse tanto em farmacologia quanto em toxicologia. Assim como muitos alcaloides, considerações de segurança e dosagem são cruciais ao explorar suas aplicações.

Fórmula: C₃₁H₃₉N₅O₅

InChI: InChI=1/C31H39N5O5/c1-16(2)26-28(38)35-11-7-10-24(35)31(40)36(26)29(39)30(41-31,17(3)4)33-27(37)19-12-21-20-8-6-9-22-25(20)18(14-32-22)13-23(21)34(5)15-19/h6,8-9,12,14,16-17,19,23-24,26,32,40H,7,10-11,13,15H2,1-5H3,(H,33,37)/t19-,23-,24+,26+,30-,31+/m1/s1

Chave InChI: InChIKey=UJYGDMFEEDNVBF-OGGGUQDZSA-N

SMILES: O[C@]12N(C(=O)[C@@](NC(=O)[C@@H]3C=C4C=5C=6C(C[C@]4(N(C)C3)[H])=CNC6C=CC5)(C(C)C)O1)[C@@H]([C@@H](C)C)C(=O)N7[C@]2(CCC7)[H]

Sinónimos:

• Ergocornine
• Ergotaman-3′,6′,18-trione, 12′-hydroxy-2′,5′-bis(1-methylethyl)-, (5′α)-
• Indolo[4,3-fg]quinoline, ergotaman-3′,6′,18-trione deriv.
• 8H-Oxazolo[3,2-a]pyrrolo[2,1-c]pyrazine, ergotaman-3′,6′,18-trione deriv.
• (5′α)-12′-Hydroxy-2′,5′-bis(1-methylethyl)ergotaman-3′,6′,18-trione
• 12′-Hydroxy-2′,5′-α-bis(1-methyl-ethyl)ergotaman-3′,6′,18-trion
• ERGOCORNINE >95% DOPAMINE RECEPTOR AGO
• ergocornin
• (5'alpha)-12'-Hydroxy-2',5'-bis(1-methylethyl)ergotaman-3',6',18-trione
• 12'-HYDROXY-2',5'-ALPHA-BIS(1-METHYL-ETHYL)ERGOTAMAN-3',6',18-TRIONE
• (5'α)-12'-Hydroxy-2',5'-bis(1-Methylethyl)ergotaMan-3',6',18-trione
• Ergotaman-3',6',18-trione, 12'-hydroxy-2',5'-bis(1-methylethyl)-, (5'α)-
• 18-trione,12’-hydroxy-2’,5’-bis(1-methylethyl)-6(5’-alpha)-ergotaman-3
• NSC 407316
• ERGOCORNINE USP/EP/BP
• Ergot Cornyn
• 12'-Hydroxy-2',5'α-diisopropylergotaman-3',6',18-trione

Ergocornine

CAS: 564-36-3

Ergocornine is a naturally occurring ergot alkaloid and acts as a dopamine receptor (dopamine receptor) agonist.

Fórmula: C₃₁H₃₉N₅O₅

Cor e Forma: Solid

Peso molecular: 561.67

Ref: TM-TN8447

Ergocornine

Produto Controlado

CAS: 564-36-3

Fórmula: C₃₁H₃₉N₅O₅

Cor e Forma: Neat

Peso molecular: 561.67

Ref: 04-C13201200

N-Nitroso Ergocorninine

CAS: 564-36-3

Fórmula: C₃₁H₃₈N₆O₆

Peso molecular: 590.68

Ref: 4Z-E-185002

Ergocornine

CAS: 564-36-3

Fórmula: C₃₁H₃₉N₅O₅

Peso molecular: 561.68

Ref: 4Z-E-220001

Ergocornine

Produto Controlado

CAS: 564-36-3

Applications Ergocornine is a natural ergot alkaloid derived from lysergic acid. Ergocornine is a component of Ergotoxine. Ergocornine is isolated from Ergot.
References Bhat, R., et al.: Toxicol. Appl. Pharmacol., 36, 11 (1976), Komarova, E., et al.: Pharm. Chem. J., 35, 542 (2001), Krska, R., et al.: Anal. Bioanal. Chem., 391, 563 (2008), Frenich, A., et al.: Food Chem., 117, 705 (2009),

Fórmula: C₃₁H₃₉N₅O₅

Cor e Forma: Neat

Peso molecular: 561.67

Ref: TR-E597350

Ergocornine

Produto Controlado

CAS: 564-36-3

Ergocornine is an ergoline alkaloid, which is a naturally occurring compound found in ergot fungi, specifically Claviceps species. These fungi predominantly infect cereal grains such as rye, leading to the production of a variety of ergot alkaloids. Ergocornine acts mainly by interacting with adrenergic receptors, displaying affinity for both alpha-adrenergic and serotonin receptor subtypes. This interaction results in vasoconstrictive and neuromodulatory effects, primarily impacting vascular and smooth muscle tissues.Ergocornine and related alkaloids have been studied extensively for their pharmacological properties. They are of particular interest due to their potential applications in treating conditions such as migraines, where the vasoconstrictive properties can mitigate the symptoms. Additionally, their effects on smooth muscles make them candidates for research in uterine contraction regulation during labor. However, due to the potent nature of these compounds and potential for toxicity, their clinical applications require careful consideration of dosage and delivery systems. Scientists continue to explore ergocornine's pharmacodynamics to better understand its therapeutic potential and safety profile.

Fórmula: C₃₁H₃₉N₅O₅

Pureza: Min. 95%

Peso molecular: 561.67 g/mol

Ref: 3D-FE30655