CAS 566-28-9

7-Cetocolesterol

Descrição:

7-Cetocolesterol é um derivado oxidado do colesterol, caracterizado pela presença de um grupo cetona na posição C7 do núcleo esteroide. Sua fórmula molecular é C27H46O e tem um peso molecular de aproximadamente 402,65 g/mol. Este composto é um esterol e é conhecido por desempenhar um papel em vários processos biológicos, incluindo sinalização celular e fluidez da membrana. 7-Cetocolesterol é frequentemente estudado no contexto de suas potenciais implicações na saúde e na doença, particularmente em relação à aterosclerose e distúrbios neurodegenerativos, pois pode influenciar o metabolismo do colesterol e a função celular. Também é reconhecido por sua capacidade de induzir estresse oxidativo e inflamação nas células. Em termos de propriedades físicas, 7-Cetocolesterol é tipicamente um sólido branco a off-white, e é solúvel em solventes orgânicos, mas tem solubilidade limitada em água. Sua reatividade e interações com outras biomoléculas fazem dele um composto significativo tanto na bioquímica quanto na farmacologia.

Fórmula: C₂₇H₄₄O₂

InChI: InChI=1/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h16-18,20-23,25,28H,6-15H2,1-5H3/t18?,20-,21+,22?,23?,25?,26-,27+/m0/s1

Chave InChI: InChIKey=YIKKMWSQVKJCOP-ABXCMAEBSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(=CC3=O)C[C@@H](O)CC4)(CC1)[H])[H])(CC[C@@]2([C@@H](CCCC(C)C)C)[H])[H]

Sinónimos:

• (3Beta)-3-Hydroxycholest-5-En-7-One
• (3S,10R,13R,17R)-17-(1,5-dimethylhexyl)-3-hydroxy-10,13-dimethyl-1,2,3,4,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-7-one
• (3β)-3-Hydroxycholest-5-en-7-one
• (5Beta,7Alpha)-7-Hydroxy-3-Oxocholan-24-Oic Acid
• 3-Beta-Hydroxycholest-5-En-7-One
• 3β-Hydroxy-cholest-5-ene-7-one
• 3β-Hydroxycholest-5-en-7-one
• 5-cholesten-3B-ol-7-one
• 7-Ketocholesterol
• 7-Oxocholesterol
• Cholest-5-en-3β-ol-7-one
• Cholest-5-en-7-one, 3-hydroxy-, (3β)-
• Cholest-5-en-7-one, 3β-hydroxy-
• Sc 4722
• Δ5-Cholesten-3β-ol-7-one
• Δ⁵-Cholesten-3β-ol-7-one
• 5-CHOLESTEN-3BETA-OL-7-ONE
• 7-KetoC
• 5A-CHOLESTAN-3B-OL-7-ONE
• Ketocholesterol
• (3-beta)-cholest-5-en-7-on
• 7-Keto Cholesterol (~98%)
• 3BETA-HYDROXY-5-CHOLESTEN-7-ONE
• 3β-Hydroxy-5-cholesten-7-one, 7-Ketocholesterol
• 3-beta-hydroxy-cholest-5-en-7-on
• (3)-3-Hydroxycholest-5-en-7-one
• 3-hydroxy-5-cholestene-7-one
• 7-Ketocholesterolk
• Cholest-5-en-3-ol-7-one
• 7-Ketocholesterol (Solution)
• sc4722
• Cholesterol 7-Keto
• (3S,8S,9S,10R,13R,14S,17R)-17-[(1R)-1,5-dimethylhexyl]-3-hydroxy-10,13-dimethyl-1,2,3,4,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-7-one
• 7-oxo-cholestero
• Cholest-5-en-7-one, 3-hydroxy-, (3.beta.)-
• 3-Hydroxycholest-5-en-7-one
• 3β-hydroxy-5-cholesten-7-one
• (3S,8S,9S,10R,13R,14S,17R)-3-hydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,3,4,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-7-one
• 3-HYDROXY-5-CHOLESTENE-7-ONE;7-KETOCHOLESTEROL
• 3-hydroxy-10,13-dimethyl-17-(6-methylheptan-2-yl)-1,2,3,4,8,9,11,12,14,15,1 6,17-dodecahydrocyclopenta[a]phenanthren-7-one

7-Ketocholesterol

CAS: 566-28-9

Fórmula: C₂₇H₄₄O₂

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 400.6371

Ref: IN-DA00E9IF

7-Keto-Cholesterol

CAS: 566-28-9

Fórmula: C₂₇H₄₄O₂

Peso molecular: 400.65

Ref: 4Z-C-5322

5-Cholesten-3Β-Ol-7-One

CAS: 566-28-9

5-Cholesten-3Β-Ol-7-One

Pureza: 98%

Peso molecular: 400.64g/mol

Ref: 54-OR1022895

7-Ketocholesterol

CAS: 566-28-9

7-Ketocholesterol

Pureza: ≥95%

Peso molecular: 400.65g/mol

Ref: 54-BUP06665

5-Cholesten-3β-ol-7-one

CAS: 566-28-9

Fórmula: C₂₇H₄₄O₂

Pureza: ≥ 98.0%

Cor e Forma: White to off-white powder

Peso molecular: 400.64

Ref: 7W-GL2633

7-Ketocholesterol

CAS: 566-28-9

Fórmula: C₂₇H₄₄O₂

Pureza: 95%~99%

Peso molecular: 400.647

Ref: BP-BP4652

7-Ketocholesterol

CAS: 566-28-9

7-Ketocholesterol is a metabolite of Cholesterol

Fórmula: C₂₇H₄₄O₂

Pureza: 97.59% - 98.84%

Cor e Forma: Solid

Peso molecular: 400.65

Ref: TM-TN6715

7-Keto Cholesterol

Produto Controlado

CAS: 566-28-9

Applications 7-Keto Cholesterol is a metabolite of Cholesterol.
References Wang, J., et al.: Biochemistry, 43, 1010 (2004), Lemaire-Ewing, S., et al.: Cell Biol. Toxicol., 21, 97 (2005), Fuda, H., et al.: J. Lipid Res., 48, 1343 ( 2007), Sasaki, H., et al.: Metabolism, 56, 357 (2007),

Fórmula: C₂₇H₄₄O₂

Pureza: ~98%

Cor e Forma: Neat

Peso molecular: 400.64

Ref: TR-K185050

7-Ketocholesterol

Produto Controlado

CAS: 566-28-9

7-Ketocholesterol is a reactive molecule that can induce inflammation and has been shown to be associated with eye disorders. 7-Ketocholesterol is an intermediate in the biosynthesis of cholesterol and is converted to 7-keto-cholesterol by the enzyme HMG-CoA reductase. This compound has also been shown to be a potent inducer of autophagy, which is a process that degrades intracellular components. 7-Ketocholesterol binds to cell nuclei and alters their shape, which may lead to cancerous cell growth. For example, this molecule induces apoptosis in cultured human retinal pigment epithelial cells. The mechanism of action for 7-ketocholesterol involves mitochondrial membrane potential, ATP binding cassette transporters, and DNA polymerase chain reaction (PCR).

Fórmula: C₂₇H₄₄O₂

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 400.64 g/mol

Ref: 3D-FK24766

7-Ketocholesterol

CAS: 566-28-9

Fórmula: C₂₇H₄₄O₂

Peso molecular: 400.6

Ref: ST-EA-CP-C71028