CAS 56602-33-6

reagente BOP

Descrição:

reagente BOP, ou benzotriazol-1-il-óxido-tris(dimetilamino)fosfonio hexafluorofosfato, é um composto químico comumente utilizado na síntese orgânica, particularmente em reações de acilação de peptídeos. Serve como um agente de acilação que facilita a formação de ligações amida entre ácidos carboxílicos e aminas. reagente BOP é caracterizado por sua capacidade de ativar ácidos carboxílicos, tornando-os mais reativos ao ataque nucleofílico por aminas. Este reagente é tipicamente preferido por suas condições de reação suaves e compatibilidade com vários grupos funcionais, o que minimiza reações secundárias. É um sólido branco a off-white que é solúvel em solventes orgânicos polares. Precauções de segurança devem ser observadas ao manusear reagente BOP, pois pode ser perigoso e causar irritação. O armazenamento adequado em um local fresco e seco, longe da umidade e substâncias incompatíveis, é essencial para manter sua estabilidade e eficácia em aplicações sintéticas.

Fórmula: C₁₂H₂₂N₆OP·F₆P

InChI: InChI=1S/C12H22N6OP.F6P/c1-15(2)20(16(3)4,17(5)6)19-18-12-10-8-7-9-11(12)13-14-18;1-7(2,3,4,5)6/h7-10H,1-6H3;/q+1;-1

Chave InChI: InChIKey=MGEVGECQZUIPSV-UHFFFAOYSA-N

SMILES: [P+](ON1C=2C(N=N1)=CC=CC2)(N(C)C)(N(C)C)N(C)C.[P+5]([F-])([F-])([F-])([F-])([F-])[F-]

Sinónimos:

• (1H-benzotriazol-1-yloxy)[tris(dimethylamino)]phosphonium hexafluorophosphate
• (Benzotriazol-1-yloxy)tris(dimethylamino) hexafluorophosphate
• (Boranyloxy)Phosphane
• 1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate
• 1H-Benzotriazole, 1-hydroxy-, phosphorus complex
• 2-(1H-Benzotriazol-1-yl)tris(dimethylamino)phosphonium hexafluorophosphate
• BOP
• BOP hexafluorophosphate
• BOP reagent
• Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate
• Benzotriazol-1-yloxytris(dimethylamino)-phosphonium hexafluorophosphate
• Castro reagent
• Castro's reagent
• Le BOP
• Methanamine, N-methyl-, phosphorus complex
• Phosphate(1-), hexafluoro-, (T-4)-(1-hydroxy-1H-benzotriazolato-O)tris(N-methylmethanaminato)phosphorus(1+)
• Phosphorus(1+), (1-hydroxy-1H-benzotriazolato-O)tris(N-methylmethanaminato)-, (T-4)-, hexafluorophosphate(1-)

1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate [Coupling Reagent for Peptide]

CAS: 56602-33-6

Fórmula: C₁₂H₂₂F₆N₆OP₂

Pureza: >98.0%(HPLC)

Cor e Forma: White to Light yellow powder to crystal

Peso molecular: 442.29

Ref: 3B-B1651

1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate, 98%

CAS: 56602-33-6

1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecarobox

Fórmula: C₁₂H₂₂F₆N₆OP₂

Pureza: 98%

Cor e Forma: Crystalline powder, White

Peso molecular: 442.29

Ref: 02-A16140

(Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate

CAS: 56602-33-6

Fórmula: C₁₂H₂₂F₆N₆OP₂

Pureza: 97%

Cor e Forma: Solid

Peso molecular: 442.2806

Ref: IN-DA0032D4

[(1H-Benzotriazol-1-yl)oxy]tris(dimethylamino)phosphonium hexafluorophosphate

CAS: 56602-33-6

[(1H-Benzotriazol-1-yl)oxy]tris(dimethylamino)phosphonium hexafluorophosphate

Fórmula: C₁₂H₂₂N₆OP·PF₆

Pureza: ≥95%

Cor e Forma: white to almost white crsytal or powder

Peso molecular: 442.28g/mol

Ref: 54-PC2519

Benzotriazol-1-yl-oxy-tris(dimethylamino) phosphonium hexafluorophosphate (BOP Reagent)

CAS: 56602-33-6

Fórmula: C₁₂H₂₂F₆N₆OP₂

Pureza: ≥ 98.0%

Cor e Forma: White to beige or light-yellow powder to crystals

Peso molecular: 442.29

Ref: 7W-GE5235

Benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate

CAS: 56602-33-6

Fórmula: C₁₂H₂₂F₆N₆OP₂

Pureza: 98.0%

Cor e Forma: Solid

Peso molecular: 442.287

Ref: 10-F009018

BOP

CAS: 56602-33-6

BOP, also known with the name of Castro’s reagent, is a phosphonium coupling reagent used for peptide synthesis. BOP can be employed in presence of a base such as triethylamine or Hünig’s base and forms HOBt in situ, which then generates an activated ester. BOP is a very effective coupling reagent, achieving high yields, low epimerisation and high conversion rates. However, it forms the extremely toxic and carcinogenic HMPA in situ, therefore the equally efficient pyrrolidino derivative PyBOP was introduced, which leads to a less toxic by-product.

Fórmula: C₁₂H₂₂F₆N₆OP₂

Pureza: Min. 98 Area-%

Cor e Forma: White Off-White Powder

Peso molecular: 442.28 g/mol

Ref: 3D-FB01762

BOP Reagent

CAS: 56602-33-6

BOP Reagent is a reagent that reacts with the phosphate group of dinucleotide phosphates, such as those found in DNA and RNA. It can be used for structural analysis and to determine the presence of nucleic acids in human serum or other biological samples. The BOP Reagent binds to the phosphate group by means of intramolecular hydrogen bonding. This reaction generates a transient, covalently-bound enzyme-substrate complex that can be detected by fluorescence probe.

Fórmula: C₁₂H₂₂N₆OF₆P₂

Pureza: Min. 95%

Peso molecular: 442.29 g/mol

Ref: 3D-KBP-1060-PI

Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate

Produto Controlado

CAS: 56602-33-6

Applications A peptide coupling reagent. Can be used in the preparation of phenyl esters of amino acids which have been shown to be valuable as blocked derivatives of amino acids in the field of peptide synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kenner, G.W., Seely, J., J. Am. Chem. Soc., 94, 3259 (1972), Castro, B., et al.: Tetrahedron Lett., 1219 (1975)

Fórmula: C₁₂H₂₂N₆OP·F₆P

Cor e Forma: Neat

Peso molecular: 442.28

Ref: TR-B207000

BOP Reagent extrapure AR, 98%

CAS: 56602-33-6

Fórmula: C₁₂H₂₂F₆N₆OP₂

Pureza: min. 98.0%

Cor e Forma: White to pale yellow, Crystalline powder, Crystalline powder

Peso molecular: 442.29

Ref: SR-59946