CAS 5681-36-7

Dipalmitoilfosfatidiletanolamina

Descrição:

Dipalmitoilfosfatidiletanolamina (DPPE) é um fosfolípido caracterizado por suas cadeias de ácidos graxos de ácido palmítico duplo (C16:0) ligadas a uma estrutura de glicerol, juntamente com um grupo cabeça de fosfoetanolamina. Esta molécula anfifílica exibe propriedades tanto hidrofílicas quanto hidrofóbicas, tornando-se um componente crucial nas membranas biológicas, particularmente na formação de bicamadas lipídicas. O DPPE é conhecido por seu papel na fusão e estabilidade de membranas, frequentemente utilizado em sistemas de entrega de medicamentos e formulações de lipossomos devido à sua capacidade de encapsular agentes terapêuticos. A substância é tipicamente encontrada em estado sólido à temperatura ambiente, com um ponto de fusão que reflete sua composição de ácidos graxos saturados. Além disso, o DPPE é reconhecido por sua biocompatibilidade e baixa toxicidade, que são essenciais para aplicações farmacêuticas. Suas características estruturais contribuem para sua função em processos celulares, incluindo dinâmica de membranas e vias de sinalização. No geral, o DPPE é um composto significativo em bioquímica e ciências farmacêuticas, facilitando várias aplicações na formulação e entrega de medicamentos.

Fórmula: C₃₇H₇₄NO₈P

InChI: InChI=1S/C37H74NO8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-36(39)43-33-35(34-45-47(41,42)44-32-31-38)46-37(40)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h35H,3-34,38H2,1-2H3,(H,41,42)

Chave InChI: InChIKey=SLKDGVPOSSLUAI-UHFFFAOYSA-N

SMILES: C(OC(CCCCCCCCCCCCCCC)=O)(COC(CCCCCCCCCCCCCCC)=O)COP(OCCN)(=O)O

Sinónimos:

• (.+-.)-1-[[[(2-Aminoethoxy)Hydroxyphosphinoyl]Oxy]Methyl]Ethane-1,2-Diyl Bishexadecanoate
• (.+-.)-1-[[[(2-Aminoethoxy)hydroxyphosphinoyl]oxy]methyl]ethan-1,2-diylbishexadecanoat
• 1,2-Dipalmitoryl-sn-glycero-3-phosphoethanolamine
• 1,2-Dipalmitoyl glycerylphosphorylethanolamine
• 1,2-Dipalmitoyl-3-<span class="text-smallcaps">DL</span>-glycerylphosphorylethanolamine
• 1,2-Dipalmitoyl-3-DL-glycerylphosphorylethanolamine
• 1,2-Dipalmitoyl-<span class="text-smallcaps">D</smallcap><smallcap>L</span>-3-glycerophosphatidylethanolamine
• 1,2-Dipalmitoyl-<span class="text-smallcaps">DL</span>-phosphatidylethanolamine
• 1,2-Dipalmitoyl-DL-3-glycerophosphatidylethanolamine
• 1,2-Dipalmitoyl-DL-phosphatidylethanolamine
• 1,2-Dipalmitoyl-rac-glycero-3-phosphoethanolamine
• 1,2-Dipalmitoyl-rac-glycerophosphoethanolamine
• 1,2-Dipalmitoylphosphatidylethanolamine
• 3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate
• <span class="text-smallcaps">D</smallcap><smallcap>L</span>-Dipalmitoylphosphatidylethanolamine
• <span class="text-smallcaps">DL</span>-α-Cephalin dipalmitate
• <span class="text-smallcaps">DL</span>-α-Dipalmitoylphosphatidylethanolamine
• Bishexadecanoate De (.+-.)-1-[[[(2-Aminoethoxy)Hydroxyphosphinoyl]Oxy]Methyl]Ethane-1,2-Diyle
• Bishexadecanoato De (.+-.)-1-[[[(2-Aminoetoxi)Hidroxifosfinoil]Oxi]Metil]Etano-1,2-Diilo
• DL-Dipalmitoylphosphatidylethanolamine
• DL-α-Cephalin dipalmitate
• DL-α-Dipalmitoylphosphatidylethanolamine
• Dipalmitoyl cephalin
• Dipalmitoylphosphatidylethanolamine
• Dppe
• Ethanol, 2-amino-, dihydrogen phosphate (ester), monoester with 1,2-dipalmitin, <span class="text-smallcaps">DL</span>-
• Hexadecanoic acid, 1,1'-[1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl] ester
• Hexadecanoic acid, 1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester
• Palmitin, 1,2-di-, 2-aminoethyl hydrogen phosphate, <span class="text-smallcaps">DL</span>-
• Palmitin, 1,2-di-, 2-aminoethyl hydrogen phosphate, DL-
• Palmitin, 1,2-di-, phosphate, 2-aminoethyl ester, dl-
• α-Cephalin, β,γ-dipalmitoyl-
• β,γ-Dipalmitoyl-<span class="text-smallcaps">DL</span>-α-cephalin

1,2-Dipalmitoyl-rac-glycero-3-phosphoethanolamine

Produto Controlado

CAS: 5681-36-7

Applications 1,2-Dipalmitoyl-rac-glycero-3-phosphoethanolamine is a long chain fatty acid, acting as a luminescence marker. Is used in enhancing radiotherapy for cancer treatment
References Dotsikas, Y. et al.: Anal. Sci., 28, 753 (2012); Choi, J. et al.: J. Nanomet., 8, 863704, (2012);

Fórmula: C₃₇H₇₄NO₈P

Cor e Forma: Neat

Peso molecular: 691.96

Ref: TR-D486820

1,2-Dipalmitoyl-rac-glycero-3-phosphoethanolamine

CAS: 5681-36-7

1,2-Dipalmitoyl-rac-glycero-3-phosphoethanolamine (DPPE) is a phospholipid that is commonly used in the formation of monolayers and bilayers. It is composed of two long hydrocarbon chains, dipalmitoyl and glycero, linked to a phosphate group and an ethanolamine headgroup. DPPE is known for its ability to form liposomes, which are spherical vesicles made up of a bilayer of phospholipids. These liposomes can be used to encapsulate drugs or other molecules and can be used as delivery vehicles for therapeutic agents. The transition from monolayer to bilayer occurs when the concentration of DPPE reaches a certain level. This transition is also affected by the presence of other lipids such as phosphatidylcholine or cholesterol, which can affect the structure and stability of the membrane bilayers.

Fórmula: C₃₇H₇₄NO₈P

Cor e Forma: Powder

Peso molecular: 691.98 g/mol

Ref: 3D-FD162266