CAS 57-64-7

(-)-Fisostigmina salicilato

Descrição:

(-)-Fisostigmina salicilato, com o número CAS 57-64-7, é um inibidor reversível da enzima acetilcolinesterase, que desempenha um papel crucial na decomposição do neurotransmissor acetilcolina. Este composto é derivado da fisostigmina, um alcaloide natural obtido do feijão de Calabar, e é frequentemente utilizado no tratamento do glaucoma e como antídoto para a toxicidade anticolinérgica. Aparece como um pó cristalino branco a off-white e é solúvel em água, tornando-o adequado para várias formulações farmacêuticas. O composto apresenta um centro quiral, resultando em sua atividade óptica específica, que é significativa para sua atividade biológica. Seu mecanismo de ação envolve a prolongação dos efeitos da acetilcolina nas sinapses, melhorando a transmissão colinérgica. Devido aos seus efeitos potentes, (-)-Fisostigmina salicilato deve ser usado com cautela, pois pode levar a efeitos colaterais como bradicardia, espasmos musculares e aumento da salivação se houver overdose. A dosagem e o monitoramento adequados são essenciais em ambientes clínicos para garantir segurança e eficácia.

Fórmula: C₁₅H₂₁N₃O₂·C₇H₆O₃

InChI: InChI=1S/C15H21N3O2.C7H6O3/c1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2;8-6-4-2-1-3-5(6)7(9)10/h5-6,9,13H,7-8H2,1-4H3,(H,16,19);1-4,8H,(H,9,10)/t13-,15+;/m1./s1

Chave InChI: InChIKey=HZOTZTANVBDFOF-PBCQUBLHSA-N

SMILES: C(O)(=O)C1=C(O)C=CC=C1.C[C@]12C=3C(N(C)[C@]1(N(C)CC2)[H])=CC=C(OC(NC)=O)C3

Sinónimos:

• (3aS,8aR)-1,3a,8-trimethyl-5-[(methylcarbamoyl)oxy]-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indolediium 2-oxidobenzoate
• 2-hydroxybenzoic acid - (3aS)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl methylcarbamate (1:1)
• Benzoic acid, 2-hydroxy-, compd. with (3aS,8aR)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-yl N-methylcarbamate (1:1)
• Benzoic acid, 2-hydroxy-, compd. with (3aS,8aR)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-yl methylcarbamate (1:1)
• Benzoic acid, 2-hydroxy-, compd. with (3aS-cis)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-yl methylcarbamate (1:1)
• Eserine salicylate salt
• Isopto Eserine
• Physostigmine salicylate
• Physostigmine, monosalicylate
• Pyrrolo[2,3-b]indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS,8aR)-, mono(2-hydroxybenzoate) (salt)
• Pyrrolo[2,3-b]indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS-cis)-, mono(2-hydroxybenzoate) (salt)
• Salicylic acid, compd. with physostigmine (1:1)
• Benzoic acid, 2-hydroxy-, compd. with (3aS,8aR)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo2,3-bindol-5-yl methylcarbamate (1:1)
• ESERINE SALICYLATE 99.9%
• PHYSOSTIGMINE SALICYLATE SALT
• physostigmine,[salicylate(1:1)]
• ESERINE SALICYLATE
• physostigmine,salicylate(1:1)
• tl-1380
• ar-44
• ESERINE SALICYLATE(RG)
• Benzoic acid, 2-hydroxy-, compd. with (3aS,8aR)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-yl methylcarbamate (1:1) (9CI)
• trimethylpyrrolo[2,3-b]indol-5-ylmethylcarbamate(1:1)
• physostolsalicylate
• salicylicacid,compd.withphysostigmine(1:1)
• PHYSOSTIGMINESALICYLATE,USP
• ESERINE MONOSALICYLATE

PHYSOSTIGMINE SALICYLATE CRS

CAS: 57-64-7

PHYSOSTIGMINE SALICYLATE CRS

Fórmula: C₂₂H₂₇N₃O₅

Cor e Forma: Colourless.

Peso molecular: 413.4669

Ref: 41-P1600000

Physostigmine Salicylate

CAS: 57-64-7

Physostigmine, a parasympathomimetic alkaloid, is a reversible cholinesterase inhibitor. It extracts from the Calabar bean.

Fórmula: C₂₂H₂₇N₃O₅

Pureza: 99.10% - >99.99%

Cor e Forma: Crystal Form That Turns Red On Exposure To Heat Or Light (Epa 1998)

Peso molecular: 413.48

Ref: TM-T0130

Physostigmine Salicylate

CAS: 57-64-7

Fórmula: C₁₅H₂₁N₃O₂·C₇H₆O₃

Peso molecular: 275.35 138.12

Ref: 4Z-P-214

Physostigmine Salicylate

Produto Controlado

CAS: 57-64-7

Fórmula: C₁₅H₂₁N₃O₂·C₇H₆O₃

Cor e Forma: Neat

Peso molecular: 413.47

Ref: 86-MM1707.00

Physostigmine Salicylate

Produto Controlado

CAS: 57-64-7

Applications Physostigmine Salicylate is a cholinesterase inhibitor with the potential to improve cognitive ability in individuals with alzheimers. In addition, as a parasympathomimetic, it is used to treat glaucoma, dry mouth, and delayed gastric emptying.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Thal, L. et al.: Neurol., 47, 1389 (1996); Hedner, E. et al.: Eur. J. Oral Sci., 109, 374 (2001);

Fórmula: C₁₅H₂₁N₃O₂·C₇H₆O₃

Cor e Forma: Neat

Peso molecular: 413.47

Ref: TR-P398510

Physostigmine Salicylate

CAS: 57-64-7

Fórmula: C₁₅H₂₁N₃O₂C₇H₆O₃

Peso molecular: 275.35 : 138.12

Ref: ST-EA-CP-P350001

Physostigmine Salicylate

CAS: 57-64-7

Vegetable alkaloids, natural or reproduced by synthesis, their salts and other derivatives, nesoi

Fórmula: C₁₅H₂₁N₃O₂·C₇H₆O₃

Cor e Forma: White Powder Crystals

Peso molecular: 413.19507

Ref: 45-1537003

Physostigmine Salicylate

CAS: 57-64-7

Cor e Forma: Neat

Ref: 61-FOR1707.00