CAS 578-76-7

7-Metilguanina

Descrição:

7-Metilguanina é uma nucleobase modificada que desempenha um papel significativo na estrutura e função dos ácidos nucleicos. É um derivado da guanina, onde um grupo metila está ligado ao átomo de nitrogênio na posição 7 do anel de purina. Essa modificação pode influenciar a estabilidade e as propriedades de emparelhamento dos ácidos nucleicos, particularmente no RNA, onde frequentemente é encontrada na estrutura de cap do mRNA, contribuindo para a estabilidade do mRNA e a eficiência da tradução. A presença de 7-Metilguanina também pode afetar a expressão gênica e os processos celulares. Em termos de propriedades físicas, é tipicamente um sólido cristalino branco a off-white, solúvel em água e solventes orgânicos. Sua fórmula molecular é C6H7N5O, e tem um peso molecular que reflete sua composição de carbono, hidrogênio, nitrogênio e oxigênio. 7-Metilguanina é de interesse na pesquisa bioquímica e tem implicações em estudos relacionados à epigenética e à regulação da expressão gênica.

Fórmula: C₆H₇N₅O

InChI: InChI=1S/C6H7N5O/c1-11-2-8-4-3(11)5(12)10-6(7)9-4/h2H,1H3,(H3,7,9,10,12)

Chave InChI: InChIKey=FZWGECJQACGGTI-UHFFFAOYSA-N

SMILES: O=C1C2=C(NC(N)=N1)N=CN2C

Sinónimos:

• 2-Amino-1,7-dihydro-7-methyl-6H-purin-6-one
• 2-Amino-7-methyl-1H-purin-6(7H)-one
• 2-Amino-7-methyl-3H-purin-6-one
• 2-Amino-7-methyl-6,7-dihydro-1H-purin-6-one
• 2-Amino-7-methyl-6,7-dihydro-3H-purin-6-one
• 2-Amino-7-methyl-7H-purin-6-ol
• 2-Amino-7-methylhypoxanthine
• 2-Imino-7-methyl-2,3,6,7-tetrahydro-1H-purin-6-one
• 2-amino-7-methyl-3,7-dihydro-6H-purin-6-one
• 6H-Purin-6-one, 2-amino-1,7-dihydro-7-methyl-
• Guanine, 7-methyl-
• N(sup 7)-Methylguanine
• N7-Methylguanine
• N⁷-Methylguanine
• NSC 19647
• Nsc 193444

7-Methylguanine

CAS: 578-76-7

Fórmula: C₆H₇N₅O

Pureza: >98.0%(T)(HPLC)

Cor e Forma: White to Light yellow powder to crystal

Peso molecular: 165.16

Ref: 3B-M3490

6H-Purin-6-one, 2-amino-1,7-dihydro-7-methyl-

CAS: 578-76-7

Fórmula: C₆H₇N₅O

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 165.1527

Ref: IN-DA00IAAH

7-Methylguanine

CAS: 578-76-7

7-Methylguanine

Pureza: 95%

Peso molecular: 165.15g/mol

Ref: 54-OR1025745

7-Methylguanine

CAS: 578-76-7

7-Methylguanine is an orally available PARP1 inhibitor (Ki=61 μM) that competes with the substrate NAD+, anticancer. a natural nucleic acid metabolite.

Fórmula: C₆H₇N₅O

Pureza: 99.99%

Cor e Forma: Solid

Peso molecular: 165.15

Ref: TM-T10194

7-Methylguanine

CAS: 578-76-7

Ref: 7W-GW0899

7-Methylguanine

CAS: 578-76-7

Applications Has binding affinity to guanine deaminase, an important metalloenzyme in purine catabolism. Found in urine of patients with malignant cancer.
References Fernandez, J. et al.; Bioorg. Med. Chem.; 18, 6748 (2010); Li, H. et al.; J. Mass. Spectrom. 44, 641 (2009)

Fórmula: C₆H₇N₅O

Cor e Forma: White Powder

Peso molecular: 165.15

Ref: TR-M311790

7-Methylguanine

CAS: 578-76-7

Temozolomide is an anticancer drug that is used in the treatment of malignant brain tumors. It is a prodrug which undergoes conversion to its active form 7-methylguanine by deamination and oxidation. Temozolomide inhibits viral replication by inhibiting the synthesis of nuclear DNA and blocking the progression of RNA polymerase. The reaction mechanism involves oxidative injury to DNA, leading to crosslinking and breakage with subsequent inhibition of polymerase chain reaction amplification. Temozolomide has been shown to have carcinogenic potential in laboratory animals. This drug has been shown to have biochemical properties that are similar to those found in other drugs such as cisplatin, vinblastine, and adriamycin, which also inhibit cellular growth through reactive oxygen species (ROS) production. Structural analysis has revealed that temozolomide binds tightly to nuclear DNA with a conformation that is similar to the natural substrate for DNA gyrase, top

Fórmula: C₆H₇N₅O

Pureza: Min. 95 Area-%

Cor e Forma: Slightly Brown Powder

Peso molecular: 165.15 g/mol

Ref: 3D-FM73256

2-Amino-7-methyl-1H-purin-6(7H)-one

CAS: 578-76-7

Fórmula: C₆H₇N₅O

Pureza: 98%

Peso molecular: 165.156

Ref: 10-F235617

7-Methylguanine

CAS: 578-76-7

Fórmula: C₆H₇N₅O

Peso molecular: 165.16

Ref: ST-EA-CP-G13004