CAS 57808-65-8
:Closantel
Descrição:
Closantel é um agente anti-helmíntico utilizado principalmente na medicina veterinária para o tratamento de infecções parasitárias em gado, particularmente em ovelhas e gado bovino. Pertence à classe de compostos conhecidos como salicilanilidas e é eficaz contra uma variedade de nematódeos e alguns cestódeos. Closantel exibe um amplo espectro de atividade, particularmente contra vermes intestinais e vermes pulmonares. O composto é caracterizado por sua natureza lipofílica, que melhora sua absorção e distribuição no corpo. Atua interrompendo o metabolismo energético dos parasitas, levando à paralisia e eventual morte deles. Closantel é tipicamente administrado por via oral ou por injeção, e sua farmacocinética permite uma eficácia prolongada, tornando-o adequado para uso na gestão de gado. Os perfis de segurança indicam que tem baixa toxicidade para mamíferos, mas deve-se ter cuidado quanto ao seu uso em animais produtores de alimentos, pois períodos de retirada são necessários para garantir que resíduos não entrem na cadeia alimentar. No geral, Closantel é uma ferramenta valiosa na parasitologia veterinária, contribuindo para a saúde e produtividade do gado.
Fórmula:C22H14Cl2I2N2O2
InChI:InChI=1/C22H14Cl2I2N2O2/c1-11-6-15(17(10-27)12-2-4-13(23)5-3-12)18(24)9-20(11)28-22(30)16-7-14(25)8-19(26)21(16)29/h2-9,17,29H,1H3,(H,28,30)
Chave InChI:InChIKey=JMPFSEBWVLAJKM-UHFFFAOYSA-N
SMILES:C(C#N)(C1=C(Cl)C=C(NC(=O)C2=C(O)C(I)=CC(I)=C2)C(C)=C1)C3=CC=C(Cl)C=C3
Sinónimos:- 5'-Chloro-4'-(4-Chloro-Alpha-Cyanobenzyl)-3,5-Diiodo-2'-Methylsalicylanilide
- 5-Diiodo-Y-
- Benzamide, N-[5-chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodo-
- Benzamide,N-(5-Chloro-4-((4-Chlorophenyl)Cyanomethyl)-2-Methylphenyl)-2-Hydrox
- Closantel Base
- Clozantin
- Faskoverm
- Iodobenzamide
- N-(5-Chloro-4-((4-Chlorophenyl)Cyanomethyl)-2-Methylphenyl)-2-Hydroxy-3,5-Di
- N-[5-Chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide
- N-{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide
- NSC 335306
- S 4105
- Seponver
- Zycloz
- Closantel
- CLOSANTEL(PATENT)
- N-[5-Chloro-4-(4-chloro-α-cyanobenzyl)-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide, 5μ-Chloro-4μ-(4-chloro-α-cyanobenzyl)-3,5-diiodo-2μ-methylsalicylanilide
- n-[5-chloro-4-[(chlorophenyl)cyannomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamid
- N-[5-CHLORO-4(4-CHLOROPHENYL)CYANOMETHYL]-2-METHYLPHENYL]-2-HYDROXYL-3,5-DIIODO BENZAMIDE
- 5'-chloro-4'-(4-chloro-α-cyanobenzyl)-3,5-diiodo-2'-methylsalicylanilide
- Closantelfreebase
- N-[5-Chloro-4-[(chlorophenyl)cyannomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide
- N-[5-CHLORO-4(4-CHLOROPHENYL)CYANOMETHYL]-2-METHYLPHENYL]-2-HYDROXYL-3,5-DIIODOBENZAMIDE(CLOSANTEL)
- N-[5-CHLORO-4-(4-CHLORO-ALPHA-CYANOBENZYL)-2-METHYLPHENYL]-2-HYDROXY-3,5-DIIODOBENZAMIDE
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100
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95
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13 produtos.
Closantel
CAS:Closantel (R-31520), a salicylanilide anthelmintic compound, shows different anthelmintic spectra and obvious toxicity in mammals.Fórmula:C22H14Cl2I2N2O2Pureza:98.52% - 99.86%Cor e Forma:White To Yellowish PowderPeso molecular:663.07N-(5-Chloro-4-((4-Chlorophenyl)(Cyano)Methyl)-2-Methylphenyl)-2-Hydroxy-3,5-Diiodobenzamide
CAS:N-(5-Chloro-4-((4-Chlorophenyl)(Cyano)Methyl)-2-Methylphenyl)-2-Hydroxy-3,5-DiiodobenzamidePureza:99+%Peso molecular:663.07g/molClosantel 100 µg/mL in Acetonitrile
CAS:Fórmula:C22H14Cl2I2N2O2Cor e Forma:Single SolutionPeso molecular:663.07Closantel 1000 µg/mL in Acetonitrile
CAS:Produto ControladoFórmula:C22H14Cl2I2N2O2Cor e Forma:Single SolutionPeso molecular:663.07Closantel
CAS:Fórmula:C22H14Cl2I2N2O2Pureza:>98.0%(HPLC)(qNMR)Cor e Forma:White to Light yellow powder to crystalPeso molecular:663.07Closantel
CAS:Produto Controlado<p>Applications Closantel is potentially useful for studying P-glycoprotein interactions in vitro.Closantel was used in preparation of Closantel-derived bacterial two-component system inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hlasta, D., et al.: Bioorg. Med. Chem. Lett., 8, 1923 (1998);<br></p>Fórmula:C22H14Cl2I2N2O2Cor e Forma:NeatPeso molecular:663.07Closantel
CAS:Closantel is a drug that is used to treat worm infections. Closantel binds to the enzyme target and inhibits its function, leading to cell death. Closantel has been shown to be effective against resistant mutants in wastewater treatment, as well as in animal studies. The enzyme inhibitor activity of closantel can be measured by electrochemical impedance spectroscopy (EIS) and fluorescence detection. It also shows protein binding properties with anthelmintic drugs. This drug has been shown to have no significant toxicity for humans at therapeutic doses, and is not detectable in human serum or urine samples when taken orally. It has been detected in human serum after intravenous administration, but this route of administration should be avoided due to the risk of serious adverse effects.Fórmula:C22H14Cl2I2N2O2Pureza:Min. 95%Cor e Forma:PowderPeso molecular:663.07 g/molN-(5-Chloro-4-((4-chlorophenyl)(cyano)methyl)-2-methylphenyl)-2-hydroxy-3,5-diiodobenzamide
CAS:Pureza:98%Peso molecular:663.07
