CAS 57918-22-6

(8S,10S)-8-Acetil-7,8,9,10-tetrahidro-6,8,11-triidroxi-1-metoxi-10-[[2,3,6-trideoxi-3-[(2,2,2-trifluoroacetil)amino]-α-L-arabino-hexopiranosil]oxi]-5,12-naftacenodiona

Descrição:

A substância química com o nome "(8S,10S)-8-Acetil-7,8,9,10-tetrahidro-6,8,11-triidroxi-1-metoxi-10-[[2,3,6-trideoxi-3-[(2,2,2-trifluoroacetil)amino]-α-L-arabino-hexopiranosil]oxi]-5,12-naftacenodiona" e o número CAS "57918-22-6" é um composto orgânico complexo caracterizado por sua intrincada estrutura molecular, que inclui múltiplos grupos funcionais, como acetila, hidroxila, metóxi e um moiety glicosídico. Este composto apresenta um núcleo de naftacenediona, o que indica sua potencial atividade biológica, possivelmente relacionada às suas interações com vários alvos biológicos. A presença de trifluoroacetila e açúcares trideóxicos sugere que pode exibir propriedades farmacológicas únicas, potencialmente influenciando sua solubilidade, estabilidade e reatividade. A estereoquímica indicada pela configuração (8S,10S) implica arranjos espaciais específicos que podem afetar significativamente as interações biológicas e a eficácia do composto. No geral, esta substância pode ser de interesse em química medicinal e farmacologia, justificando uma investigação adicional sobre suas potenciais aplicações e mecanismos de ação.

Fórmula: C₂₉H₂₈F₃NO₁₁

InChI: InChI=1S/C29H28F3NO11/c1-10-22(35)14(33-27(40)29(30,31)32)7-17(43-10)44-16-9-28(41,11(2)34)8-13-19(16)26(39)21-20(24(13)37)23(36)12-5-4-6-15(42-3)18(12)25(21)38/h4-6,10,14,16-17,22,35,37,39,41H,7-9H2,1-3H3,(H,33,40)/t10-,14-,16-,17-,22-,28-/m0/s1

Chave InChI: InChIKey=VOASREXNXKOKBP-VMPUWYRSSA-N

SMILES: OC=1C2=C([C@@H](O[C@H]3C[C@H](NC(C(F)(F)F)=O)[C@@H](O)[C@H](C)O3)C[C@@](C(C)=O)(O)C2)C(O)=C4C1C(=O)C=5C(C4=O)=C(OC)C=CC5

Sinónimos:

• (8S,10S)-8-Acetyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-[[2,3,6-trideoxy-3-[(2,2,2-trifluoroacetyl)amino]-α-<span class="text-smallcaps">L</span>-arabino-hexopyranosyl]oxy]-5,12-naphthacenedione
• (8S-cis)-8-Acetyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-((2,3,6-trideoxy-3-((trifluoroacetyl)amino)-alpha-L-arabino-hexopyranosyl)oxy)naphthacene-5,12-dione
• 3-Acetyl-3,5,12-Trihydroxy-10-Methoxy-6,11-Dioxo-1,2,3,4,6,11-Hexahydrotetracen-1-Yl 2,3,6-Trideoxy-3-[(Trifluoroacetyl)Amino]Hexopyranoside
• 4′-epi-N-Trifluoroacetyldaunorubicin
• 5,12-Naphthacenedione, 8-acetyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-[[2,3,6-trideoxy-3-[(2,2,2-trifluoroacetyl)amino]-α-<span class="text-smallcaps">L</span>-arabino-hexopyranosyl]oxy]-, (8S,10S)-
• 5,12-Naphthacenedione, 8-acetyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-[[2,3,6-trideoxy-3-[(trifluoroacetyl)amino]-α-<span class="text-smallcaps">L</span>-arabino-hexopyranosyl]oxy]-, (8S,10S)-
• 5,12-Naphthacenedione, 8-acetyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-[[2,3,6-trideoxy-3-[(trifluoroacetyl)amino]-α-<span class="text-smallcaps">L</span>-arabino-hexopyranosyl]oxy]-, (8S-cis)-
• NSC 176325
• (8S,10S)-8-Acetyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-[[2,3,6-trideoxy-3-[(2,2,2-trifluoroacetyl)amino]-α-L-arabino-hexopyranosyl]oxy]-5,12-naphthacenedione
• 5,12-Naphthacenedione, 8-acetyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-[[2,3,6-trideoxy-3-[(trifluoroacetyl)amino]-α-L-arabino-hexopyranosyl]oxy]-, (8S,10S)-
• 5,12-Naphthacenedione, 8-acetyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-[[2,3,6-trideoxy-3-[(2,2,2-trifluoroacetyl)amino]-α-L-arabino-hexopyranosyl]oxy]-, (8S,10S)-

Epirubicin Impurity 7

CAS: 57918-22-6

Fórmula: C₂₉H₂₈F₃NO₁₁

Peso molecular: 623.53

Ref: 4Z-E-144011

4'-epi-N-Trifluoroacetyldaunorubicin

Produto Controlado

CAS: 57918-22-6

Applications 4'-epi-N-Trifluoroacetyldaunorubicin is an intermediate used in the synthesis of 4’-epi-Daunorubicin (D194490), which is a Daunorubicin (D194500) impurity. Daunomycin analog antitumor.
References Cassinelli, G., et al.: J. Antib., 38, 856 (1985), Arcamone, F., et al.: J. Med. Chem.,18, 703 (1975),

Fórmula: C₂₉H₂₈F₃NO₁₁

Cor e Forma: Neat

Peso molecular: 623.528

Ref: TR-T786980

4-Epi-N-trifluoroacetyldaunorubicin

CAS: 57918-22-6

4-Epi-N-trifluoroacetyldaunorubicin is an analog of the anticancer drug daunorubicin that has shown potent antitumor activity in Chinese hamster ovary (CHO) cells. It is a kinase inhibitor that targets multiple kinases involved in cancer cell proliferation and survival. This drug has been shown to induce apoptosis in cancer cells by inhibiting protein synthesis and DNA replication. 4-Epi-N-trifluoroacetyldaunorubicin has also been found to be effective against tumors that are resistant to other chemotherapy drugs, making it a promising candidate for cancer treatment. In addition, this compound has been studied as a potential therapy for polycystic kidney disease, as it has been shown to reduce urine volume and improve renal function when used with the drug tolvaptan.

Fórmula: C₂₉H₂₈F₃NO₁₁

Pureza: Min. 95%

Peso molecular: 623.5 g/mol

Ref: 3D-HCA91822