CAS 58-05-9

Leucovorina

Descrição:

Leucovorina, também conhecido como ácido folínico, é uma forma reduzida do ácido fólico que desempenha um papel crucial em vários processos bioquímicos, particularmente na síntese de ácidos nucleicos e aminoácidos. É comumente utilizado em ambientes médicos como agente de resgate após a terapia com metotrexato, pois pode ajudar a mitigar os efeitos tóxicos do medicamento em células saudáveis, fornecendo uma fonte de folato ativo. Leucovorina é um pó cristalino branco a off-white que é solúvel em água, tornando-o adequado para administração intravenosa ou oral. Sua estrutura química inclui um anel de pteridina, um grupo ácido para-aminobenzoico e um resíduo de ácido glutâmico, que contribuem para sua atividade biológica. Leucovorina também é utilizado em combinação com fluorouracilo para aumentar sua eficácia no tratamento de certos cânceres. Devido ao seu papel no metabolismo celular, é essencial para a síntese e reparo adequados do DNA, tornando-o vital em contextos terapêuticos e fisiológicos.

Fórmula: C₂₀H₂₃N₇O₇

InChI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12?,13-/m0/s1

Chave InChI: InChIKey=VVIAGPKUTFNRDU-ABLWVSNPSA-N

SMILES: C(=O)N1C2=C(NCC1CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)NC(N)=NC2=O

Sinónimos:

• (6R,S)-5-Formyltetrahydrofolate
• 10-Formyl-7,8-dihydrofolic acid
• 5-Formyl-5,6,7,8-tetrahydrofolic acid
• 5-Formyltetrahydrofolic Acid
• 5-Formyltetrahydrofolsaure
• 5-Formyltetrahydropteroylglutamic acid
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2-amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
• Acide 5-Formyltetrahydrofolique
• Acido 5-Formiltetrahidrofolico
• CF
• Folinic acid
• Folinic acid-SF
• Glutamic acid, N-[p-[[(2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-, <span class="text-smallcaps">L</span>-
• Glutamic acid, N-[p-[[(2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-, L-
• Kunyrin
• L-Glutamic acid, N-[4-[[(2-amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
• Leucal
• Leucoverin
• Leucovorin
• Levoleucovorin
• N-[4-[[(2-Amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-<span class="text-smallcaps">L</span>-glutamic acid
• N5-Formyl-5,6,7,8-tetrahydrofolic acid
• N5-Formyltetrahydrofolic acid
• N⁵-Formyl-5,6,7,8-tetrahydrofolic acid
• N⁵-Formyl-THF
• N⁵-Formyltetrahydrofolic acid
• Welcovorin
• l-Leucovorin
• N-[4-({[(6S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid
• N-(4-{[(2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
• 5-formyltetrahydrofolate
• L-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
• N-(4-{[(2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}benzoyl)glutamic acid
• N-[4-[[(2-Amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
• N5-formyl-5,6,7,8-tetrahydrofolate
• N5-formyl-tetrahydrofolate

Calcium Folinate

CAS: 1492-18-8, 2060570-47-8, 58-05-9, 6035-45-6

Fórmula: C₂₀H₂₁CaN₇O₇

Pureza: >98.0%(T)(HPLC)

Cor e Forma: Light orange to Yellow to Green powder to crystaline

Peso molecular: 511.51

Ref: 3B-C2235

(2S)-2-[[4-[(2-Amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid

CAS: 58-05-9

Fórmula: C₂₀H₂₃N₇O₇

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 473.4393

Ref: IN-DA003A0Z

Folinic acid

CAS: 58-05-9

Folinic acid

Pureza: ≥98%

Peso molecular: 473.44g/mol

Ref: 54-BUP11034

Folinic Acid

CAS: 58-05-9

Folinic Acid

Pureza: 98%

Peso molecular: 473.44g/mol

Ref: 54-OR1027762

Folinic Acid

CAS: 58-05-9

Applications Folinic Acid is used in combination with 5-fluorouracil in the treatment of colorectal cancers. It also functions as a useful antidotal therapy medication for decreasing the toxic effect of methotrexate overdosing.
References He, J., et al.: Cancer Sci., 111, 253 (2020); Labriet, A., et al.: Pharmacogenomics, 20, 1179 (2019); Pannu, A. K.: Curr. Drug Metab., 20, 714 (2019)

Fórmula: C₂₀H₂₃N₇O₇

Cor e Forma: Neat

Peso molecular: 473.45

Ref: TR-F680340

Folinic acid

CAS: 58-05-9

Folinic acid (Leucovorin) is a biofolic acid that can be used in the treatment of methotrexate, often in combination with Methotrexate (MTX) to reduce MTX-

Fórmula: C₂₀H₂₃N₇O₇

Pureza: 99.76%

Cor e Forma: Crystals From Water With 3 Mol Of Water Of Crystallization Solid

Peso molecular: 473.44

Ref: TM-T24403

Folinic acid

CAS: 58-05-9

Folinic acid is a vitamin-B9 that is used as a cofactor for enzymes involved in the synthesis of DNA and RNA. It is also used to diagnose various infectious diseases, with high values found in patients with cancer or autoimmune diseases. Folinic acid has been shown to have dose-dependent effects on mammalian cells, exhibiting toxicities at higher concentrations. Folinic acid can be used to repair damaged DNA by acting as a glycosidase that breaks down the glycosidic bond between the base and sugar.

Fórmula: C₂₀H₂₃N₇O₇

Pureza: (%) Min. 97%

Cor e Forma: White Powder

Peso molecular: 473.44 g/mol

Ref: 3D-FF156776