CAS 58-58-2

Cloridrato de puromicina

Descrição:

Cloridrato de puromicina é um composto antibiótico derivado da bactéria *Streptomyces alboniger*. É conhecido principalmente por seu papel como inibidor da síntese de proteínas, direcionando-se especificamente à maquinaria ribossomal de células procariontes e eucariontes. O composto funciona imitando a estrutura do aminoacil-tRNA, levando à terminação prematura das cadeias polipeptídicas durante a tradução. Cloridrato de puromicina é tipicamente apresentado como um pó cristalino branco a off-white, solúvel em água e em vários solventes orgânicos. Sua fórmula molecular inclui elementos como carbono, hidrogênio, nitrogênio e oxigênio, contribuindo para sua atividade biológica. Em ambientes de laboratório, a puromicina é amplamente utilizada em biologia molecular para selecionar células geneticamente modificadas, pois pode eliminar efetivamente células não resistentes. No entanto, devido aos seus efeitos potentes, o manuseio requer cautela e as medidas de segurança adequadas devem ser observadas. No geral, Cloridrato de puromicina serve como uma ferramenta valiosa na pesquisa, particularmente em estudos relacionados à expressão gênica e síntese de proteínas.

Fórmula: C₂₂H₂₉N₇O₅·2ClH

InChI: InChI=1S/C22H29N7O5.2ClH/c1-28(2)19-17-20(25-10-24-19)29(11-26-17)22-18(31)16(15(9-30)34-22)27-21(32)14(23)8-12-4-6-13(33-3)7-5-12;;/h4-7,10-11,14-16,18,22,30-31H,8-9,23H2,1-3H3,(H,27,32);2*1H/t14-,15+,16+,18+,22+;;/m0../s1

Chave InChI: InChIKey=MKSVFGKWZLUTTO-FZFAUISWSA-N

SMILES: O[C@H]1[C@H](N2C=3C(N=C2)=C(N(C)C)N=CN3)O[C@H](CO)[C@H]1NC([C@H](CC4=CC=C(OC)C=C4)N)=O.Cl

Sinónimos:

• Adenosine, 3′-[[(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3′-deoxy-N,N-dimethyl-, hydrochloride (1:2)
• Adenosine, 3′-(α-amino-p-methoxyhydrocinnamamido)-3′-deoxy-N,N-dimethyl-, dihydrochloride, L-
• Adenosine, 3′-[[2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3′-deoxy-N,N-dimethyl-, dihydrochloride, (S)-
• Adenosine, 3′-[[(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3′-deoxy-N,N-dimethyl-, dihydrochloride
• CL 16,536

Puromycin dihydrochloride, 98%

CAS: 58-58-2

Puromycin dihydrochloride, 58-58-2, also known as stylomycin hydrochloride, is an aminoglycoside antibiotic which acts by inhibiting protein synthesis. Learn more.

Fórmula: C₂₂H₃₁Cl₂N₇O₅

Pureza: 98%

Cor e Forma: White to pale cream, Powder

Peso molecular: 544.43

Ref: 02-J61278

Puromycin dihydrochloride, 10 mg/ml in distilled water, sterile-filtered

CAS: 58-58-2

Puromycin, 58-58-2, is an aminoglycoside antibiotic produced by Streptomyces alboniger which acts by inhibiting protein synthesis. Learn more at Thermo Fisher Scientific.

Fórmula: C₂₂H₂₉N₇O₅

Cor e Forma: Clear colorless to pale cream, Liquid

Peso molecular: 471.52

Ref: 02-J67236

Adenosine,3'-[[(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyl-, dihydrochloride

CAS: 58-58-2

Fórmula: C₂₂H₃₁Cl₂N₇O₅

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 544.4314

Ref: IN-DA00IABE

Puromycin dihydrochloride

CAS: 58-58-2

Puromycin dihydrochloride

Fórmula: C₂₂H₂₉N₇O₅·2ClH

Pureza: By hplc: 98.48% (Typical Value in Batch COA)

Cor e Forma: off-white powder

Peso molecular: 544.43g/mol

Ref: 54-BIP3340

Puromycin dihydrochloride (animal free)

CAS: 58-58-2

Puromycin dihydrochloride (animal free)

Fórmula: C₂₂H₂₉N₇O₅·2ClH

Pureza: By hplc: 99.07% (Typical Value in Batch COA)

Cor e Forma: slightly pink powder

Peso molecular: 544.43g/mol

Ref: 54-BIP4033

Puromycin dihydrochloride

CAS: 58-58-2

Puromycin dihydrochloride

Pureza: ≥98%

Peso molecular: 544.44g/mol

Ref: 54-BUP13663

Puromycin DiHCl

CAS: 58-58-2

Fórmula: C₂₂H₂₉N₇O₅·2HCl

Peso molecular: 471.52 2 36.46

Ref: 4Z-P-301001

Puromycin dihydrochloride

CAS: 58-58-2

Puromycin dihydrochloride, from Streptomyces alboniger, blocks protein synthesis, acting as an antineoplastic and antitrypanosomal agent.

Fórmula: C₂₂H₃₁Cl₂N₇O₅

Pureza: 98.65% - 99.89%

Cor e Forma: Physical Description White Powder (Ntp 1992)

Peso molecular: 544.44

Ref: TM-T2219

Puromycin dihydrochloride

CAS: 58-58-2

Fórmula: C₂₂H₂₉N₇O₅·2HCl

Pureza: ≥ 98.0%

Cor e Forma: White to off-white powder

Peso molecular: 544.44

Ref: 7W-GA1940

Puromycin Dihydrochloride

Produto Controlado

CAS: 58-58-2

Applications Puromycin is an aminonucleoside antibitotic. Puromycin acts as a protein synthesis inhibitor which interferes with translation by inhibiting ribosome functions. Puromycin is also a reversible inhibitor of dipeptidyl-peptidase II (serine peptidase) and cytosol alanyl aminopeptidase.
References Pestka, S. et al.: Ann. Rev. Micromiol., 8, 1559 (1997); Dando, P.M. et al.: Biomed. Health Res., 13, 88 (1997); McDonald, J.K. et al.: J. Biol. Chem., 243, 2028 (1968);

Fórmula: C₂₂H₂₉N₇O₅·2ClH

Cor e Forma: Neat

Peso molecular: 544.43

Ref: TR-P840320

Puromycin dihydrochloride

CAS: 58-58-2

Puromycin is active against both prokaryotic and eukaryotic cells. Puromycin resistance gene (pac) is a common choice for the selection of mammalian cells since its first application in 1988, especially for therapeutic proteins in mammalian cells where it was used to produce high levels of protein of interest. Puromycin can also be used as a selection marker for Archea.

Fórmula: C₂₂H₃₁Cl₂N₇O₅

Pureza: Min. 98 Area-%

Cor e Forma: White Powder

Peso molecular: 544.44 g/mol

Ref: 3D-NP09203

Puromycin Dihydrochloride (PRM), 98%

CAS: 58-58-2

Fórmula: C₂₂H₂₉N₇O₅·2HCl

Pureza: min. 98%

Cor e Forma: White to pale yellow, Powder

Peso molecular: 544.44

Ref: SR-93909

Puromycin Dihydrochloride (PRM) for cell culture, Endotoxin (BET) 10EU/mg

CAS: 58-58-2

Fórmula: C₂₂H₂₉N₇O₅·2HCl

Pureza: min. 98%

Cor e Forma: White to pale yellow, Powder

Peso molecular: 544.44

Ref: SR-82361

Puromycin dihydrochloride

CAS: 58-58-2

M02245 - Puromycin dihydrochloride

Fórmula: C₂₂H₃₁Cl₂N₇O₅

Pureza: 98%

Cor e Forma: Solid, Powder

Peso molecular: 544.43

Ref: 10-M02245

Puromycin-D3 Dihydrochloride

Produto Controlado

CAS: 58-58-2

Applications Puromycin-D3 Dihydrochloride is a labelled analogue of Puromycin Dihydrochloride (P840320), an aminonucleoside antibitotic. Puromycin acts as a protein synthesis inhibitor which interferes with translation by inhibiting ribosome functions. Puromycin is also a reversible inhibitor of dipeptidyl-peptidase II (serine peptidase) and cytosol alanyl aminopeptidase.
References Pestka, S. et al.: Ann. Rev. Micromiol., 8, 1559 (1997); Dando, P.M. et al.: Biomed. Health Res., 13, 88 (1997); McDonald, J.K. et al.: J. Biol. Chem., 243, 2028 (1968);

Fórmula: C₂₂H₂₆D₃N₇O₅•2(HCl)

Cor e Forma: Neat

Peso molecular: 474.53 + 2(36.46)

Ref: TR-P840322