CAS 58288-50-9

Hidroxocobalamina cloridrato

Descrição:

Hidroxocobalamina cloridrato é uma forma de vitamina B12, especificamente um composto de cobalamina, caracterizado por sua cor vermelha devido à presença de cobalto. É uma vitamina solúvel em água que desempenha um papel crucial em vários processos biológicos, incluindo a síntese de DNA, a formação de glóbulos vermelhos e a função neurológica. A hidroxocobalamina é frequentemente usada em ambientes clínicos como tratamento para a deficiência de vitamina B12 e como antídoto para envenenamento por cianeto devido à sua capacidade de se ligar a íons de cianeto, formando um complexo não tóxico. O composto é tipicamente administrado por vias intramusculares ou intravenosas, e sua farmacocinética envolve armazenamento no fígado, onde pode ser liberado conforme necessário. Hidroxocobalamina cloridrato é geralmente bem tolerado, com efeitos colaterais raros, mas que podem incluir reações alérgicas ou reações no local da injeção. Sua estabilidade e eficácia o tornam um agente terapêutico valioso tanto na suplementação nutricional quanto na medicina de emergência.

Fórmula: C₆₂H₈₉CoN₁₃O₁₅P·xClH

InChI: InChI=1S/C62H90N13O14P.ClH.Co.H2O/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;;;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);1H;;1H2/q;;+3;/p-3

Chave InChI: InChIKey=KEHNCSYXYMMUCO-UHFFFAOYSA-K

SMILES: [OH-][Co+3]1234[N]=5C6(C)C7[N-]1C(C(C)(C7CC(N)=O)CCC(=O)NCC(C)OP(=O)([O-])OC8C(O)C(N9C=[N]2C=%10C9=CC(C)=C(C)C%10)OC8CO)=C(C)C%11=[N]3C(=CC%12=[N]4C(=C(C)C5C(CCC(N)=O)C6(CC(N)=O)C)C(CC(N)=O)(C)C%12CCC(N)=O)C(C)(C)C%11CCC(N)=O.Cl

Sinónimos:

• Cobinamide, Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3′-ester with (5,6-dimethyl-1-α-<span class="text-smallcaps">D</span>-ribofuranosyl-1H-benzimidazole-κN³), hydrochloride
• Cobinamide, Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3′-ester with (5,6-dimethyl-1-α-<span class="text-smallcaps">D</span>-ribofuranosyl-1H-benzimidazole-κN³), hydrochloride (1:?)
• Cobinamide, dihydroxide, dihydrogen phosphate (ester), mono(inner salt), 3′-ester with 5,6-dimethyl-1-α-<span class="text-smallcaps">D</span>-ribofuranosyl-1H-benzimidazole, hydrochloride
• Hydroxocobalamin Chloride
• Hydroxocobalamine Hydrochloride
• Vitamin B12A Hydrochloride
• hydroxocobalamin HCl
• hydroxy-[(1R,2R,3R,4Z,7S,9Z,12S,13S,14Z,17S,18S,19R)-2,13,18-tris(2-amino-2-oxo-ethyl)-7,12,17-tris(3-amino-3-oxo-propyl)-3-[3-[[(2R)-2-[[(2R,3S,4R,5S)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl]oxy-oxido-phosphoryl]oxypropyl]amino]-3-oxo-propyl]-3,5,8,8,13,15,18,19-octamethyl-2,7,12,17-tetrahydro-1H-corrin-21-yl]cobalt(1+) hydrochloride
• Hydroxocobalamin hydrochloride
• Cobinamide, Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3′-ester with (5,6-dimethyl-1-α-D-ribofuranosyl-1H-benzimidazole-κN3), hydrochloride
• Cobinamide, Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3′-ester with (5,6-dimethyl-1-α-D-ribofuranosyl-1H-benzimidazole-κN3), hydrochloride (1:?)

HYDROXOCOBALAMIN CRS

CAS: 58288-50-9

HYDROXOCOBALAMIN CRS

Ref: 41-H1428000

Cobinamide, Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3'-esterwith (5,6-dimethyl-1-a-D-ribofuranosyl-1H-benzimidazole-kN3),hydrochloride

CAS: 58288-50-9

Fórmula: C₆₂H₉₀ClCoN₁₃O₁₅P

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 1382.8161

Ref: IN-DA00E91P

Vitamin B12a hydrochloride

CAS: 58288-50-9

Vitamin B12a monohydrochloride (Hydroxocobalamin) is an essential water-soluble vitamin.a cyanide detoxifier and nutritional supplement, injection, inhalation.

Fórmula: C₆₂H₈₉CoN₁₃O₁₅P·xHCl

Cor e Forma: Solid

Ref: TM-T204095

Hydroxocobalamin hydrochloride

CAS: 58288-50-9

Fórmula: C₆₂H₈₉CoN₁₃O₁₅P·HCl

Pureza: 96.0 - 102.0 %

Cor e Forma: Off-white to dark red or brown crystalline powder

Peso molecular: 1382.82

Ref: 7W-GE2054

Hydroxocobalamin Xhydrochloride

CAS: 58288-50-9

Hydroxocobalamin Xhydrochloride

Pureza: 98%

Peso molecular: 1,382.82g/mol

Ref: 54-OR1013543

Vitamin B12a

CAS: 58288-50-9

Fórmula: C₆₂H₉₀ClCoN₁₃O₁₅P

Peso molecular: 1382.82

Ref: 7W-GL8242

Hydroxocobalamin HCl

CAS: 58288-50-9

Hydroxocobalamin HCl is a vitamin that is required for the formation of coenzyme B12. It is used to treat megaloblastic anemia, pernicious anemia, and other conditions in which vitamin B12 is deficient. Hydroxocobalamin HCl also has been shown to have physiological effects, including the inhibition of enzyme activities such as nitrite reductase and sephadex g-100. This drug binds to a number of enzymes, including group P2 enzymes (e.g., nitrate reductase) and thermolytic enzymes (e.g., hydroxylases). Hydroxocobalamin HCl has a redox potential that allows it to act as a hydrogen donor in reactions with electron acceptors such as nitrite ion or oxygen. The mechanism of action of hydroxocobalamin includes its ability to reduce intramolecular hydrogen molecules, which can be transferred to other molecules in the reaction system such as

Fórmula: C₆₂H₈₉CoN₁₃O₁₅P•(HCl)x

Pureza: Min. 90 Area-%

Cor e Forma: Powder

Peso molecular: 1,346.35 g/mol

Ref: 3D-FH45888

Hydroxocobalamin Hydrochloride (>85%)

CAS: 58288-50-9

Applications Hydroxocobalamin Hydrochloride acts as a spin trap for radical polymerization in water when reduced with ascorbic acid.
References Ng, Y., et al.: Macromol. Res., 20, 473-476 (2012)

Fórmula: C₆₂H₈₉CoN₁₃O₁₅P·ClH

Cor e Forma: Neat

Peso molecular: 1382.82

Ref: TR-H862823

Cyanocobalamin EP Impurity H Chloride (Hydroxocobalamin Chloride)

CAS: 58288-50-9

Fórmula: C₆₂H₈₉CoN₁₃O₁₅P·HCl

Peso molecular: 1382.82 36.46

Ref: 4Z-C-165020