CAS 58569-55-4

(5-metionina)encefalina

Descrição:

(5-metionina)encefalina, também conhecido como Met-enkephalina, é um pentapeptídeo que desempenha um papel significativo na modulação da dor e na resposta ao estresse do corpo. É composto por cinco aminoácidos, especificamente tirosina, glicina, fenilalanina, leucina e metionina, sendo a metionina o quinto aminoácido no C-terminal. Este peptídeo é um opioide endógeno, o que significa que é produzido naturalmente no corpo e se liga aos receptores opioides, particularmente ao receptor delta-opioide, para exercer efeitos analgésicos. A Met-enkephalina está envolvida em vários processos fisiológicos, incluindo alívio da dor, regulação do humor e modulação das respostas imunológicas. É solúvel em água e apresenta estabilidade em condições fisiológicas, embora possa ser suscetível à degradação enzimática. O número CAS 58569-55-4 identifica exclusivamente este composto em bancos de dados químicos, facilitando a pesquisa e aplicação em farmacologia e bioquímica. Seu estudo tem implicações para o desenvolvimento de terapias de manejo da dor e compreensão dos mecanismos de dependência e transtornos de humor.

Fórmula: C₂₇H₃₅N₅O₇S

InChI: InChI=1/C27H35N5O7S/c1-40-12-11-21(27(38)39)32-26(37)22(14-17-5-3-2-4-6-17)31-24(35)16-29-23(34)15-30-25(36)20(28)13-18-7-9-19(33)10-8-18/h2-10,20-22,33H,11-16,28H2,1H3,(H,29,34)(H,30,36)(H,31,35)(H,32,37)(H,38,39)/t20-,21-,22-/m0/s1

Sinónimos:

• 10: PN: WO2008008805 SEQID: 10 unclaimed protein
• 153: PN: US20030176421 PAGE: 54-55 claimed protein
• 16: PN: EP1498113 PAGE: 14 claimed protein
• 25: PN: WO2005095443 SEQID: 25 claimed protein
• 3: PN: WO2008052043 SEQID: 2 claimed protein
• 46: PN: US6017496 PAGE: 120 claimed protein
• 5-L-Methionine-enkephalin
• 5-Methionine enkephalin
• Adrenorphin (human), 6-de-L-arginine-7-de-L-arginine-8-de-L-valinamide-
• Enkephalin, methionine
• Human β-endorphin(1-5)
• L-Methionine-enkephalin
• Lupex
• Met5-enkephalin
• Metenkefalin
• Met-enkephalin
• Methionine enkephalin
• Methionyl-enkephalin
• N-[N-[N-(N-L-tirosilglicil)glicil]-L-fenilalanil]-L-metionina
• N-[N-[N-(N-L-Tyrosylglycyl)glycyl]-L-phenylalanyl]-L-methionin
• N-[N-[N-(N-L-tyrosylglycyl)glycyl]-L-phenylalanyl]-L-methionine
• Nsc 374896
• Opioid growth factor
• Peptid-M
• PN: US5961923 PAGE: 135 claimed protein
• Porcine β-endorphin 1-5
• Tyr-Gly-Gly-Phe-Met-OH
• β-Endorphin(1-5)
• L-tyrosylglycylglycyl-L-phenylalanyl-L-methionine
• methionine enkephalin acetate
• H-Tyr-Gly-Gly-Phe-Met-OH
• tyrosylglycylglycylphenylalanylmethionine

Met-Enkephalin

CAS: 58569-55-4

Opioid growth factor (OGF) and its receptor form a biological axis that tonically regulates cell proliferation by delaying the G1/S interface of the cell cycle under homeostatic conditions or in neoplasia. Exogenous OGF represses growth of human pancreatic cancer cells in culture and in nude mice. OGF therapy alone or in combination with standard chemotherapies results in enhanced inhibition of DNA synthesis and tumor growth.

Fórmula: C₂₇H₃₅N₅O₇S

Pureza: 99.8%

Cor e Forma: White

Peso molecular: 573.67

Ref: 01-4000010

H-TYR-GLY-GLY-PHE-MET-OH

CAS: 58569-55-4

Fórmula: C₂₇H₃₅N₅O₇S

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 573.6611

Ref: IN-DA00E8Q0

Tyr-Gly-Gly-Phe-Met-OH

CAS: 58569-55-4

Tyr-Gly-Gly-Phe-Met-OH

Pureza: ≥95%

Peso molecular: 573.66g/mol

Ref: 54-BUP11145

Met-Enkephaline

CAS: 58569-55-4

Fórmula: C₂₇H₃₅N₅O₇S

Pureza: 95%~99%

Cor e Forma: White to Off-white Powder

Peso molecular: 573.661

Ref: BP-BPPG049

Tyr-Gly-Gly-Phe-Met-OH

CAS: 58569-55-4

Tyr-Gly-Gly-Phe-Met-OH (Met-Enkephalin), is a naturally occurring, endogenous opioid peptide that inhibits tumor growth via binding to the opioid receptor.

Fórmula: C₂₇H₃₅N₅O₇S

Pureza: ≥95%

Cor e Forma: White Lyophilised Solid

Peso molecular: 573.66

Ref: TM-T7211

Met-enkephalin

CAS: 58569-55-4

Stability Unstable in alkaline solution
Applications Met-enkephalin is an endogenous opioid peptide that increases expression levels of δ, μ and κ-opioid receptors, inhibits growth, apoptosis and proliferation in human melanoma A375 cells. Antitumor effect via regulating dendritic cells. Regulation of the immune system, therapy effects of antitumor, autoimmune diseases, AIDS, and other immune-related diseases.
References Wang, D., et al.: Mol. Med. Rep., 14, 5521 (2016); Feng, P., et al.: Weishengwuxue Zazhi, 35, 100 (2015); Meng, Y., et al.: Int. Immunopharmacol., 44, 61 (2017)

Fórmula: C₂₇H₃₅N₅O₇S

Cor e Forma: Neat

Peso molecular: 573.66

Ref: TR-M225485

Methionine-Enkephalin (Human, Porcine, Bovine, Rat, Mouse)

CAS: 58569-55-4

Methionine-Enkephalin is a peptide that is derived from the amino acid methionine. It has been shown to act on ion channels and the receptor, as well as having a number of other biological effects. Methionine-Enkephalin can be used in research for pharmacology and protein interactions. This product is an antibody against methionine-enkephalin. It can be used for cell biology and immunology research, as it recognizes the peptide sequence of methionine-enkephalin. This antibody can also be used to inhibit the activity of this peptide.

Fórmula: C₂₇H₃₅N₅O₇S

Pureza: Min. 95%

Peso molecular: 573.66 g/mol

Ref: 3D-PEK-4042-V

Methionine-Enkephalin (Human, Porcine, Bovine, Rat, Mouse)

CAS: 58569-55-4

Methionine-Enkephalin (ME) is a peptide that has been shown to bind to the opioid receptor and inhibit the production of pro-inflammatory cytokines. ME has been shown to have an inhibitory effect on human liver cells, as well as on cultured human epidermal cells. ME may also have a role in epidermal growth factor receptors, which could be related to its anti-inflammatory effects.

Fórmula: C₂₇H₃₅N₅O₇S•H₂O

Pureza: Min. 95%

Peso molecular: 591.68 g/mol

Ref: 3D-PEK-4042