CAS 58970-76-6
:Bestatina
Descrição:
Bestatina é um composto químico conhecido por seu papel como um potente inibidor de aminopeptidases, particularmente da aminopeptidase N. É classificado como um dipeptídeo, consistindo nos aminoácidos L-fenilalanina e L-leucina. Bestatina exibe uma estrutura única que lhe permite se ligar efetivamente ao sítio ativo das aminopeptidases, inibindo assim sua atividade enzimática. Essa inibição tem implicações em vários processos biológicos, incluindo a modulação da resposta imunológica e o tratamento do câncer. Bestatina também é notado por seu potencial uso na melhoria da eficácia de certos agentes quimioterápicos. O composto é tipicamente administrado em um contexto farmacêutico, e seu perfil de segurança foi avaliado em estudos clínicos. Assim como muitos compostos bioativos, a farmacocinética e o metabolismo de Bestatina são importantes para entender suas aplicações terapêuticas e potenciais efeitos colaterais. No geral, Bestatina representa um interesse significativo em química medicinal devido às suas propriedades de inibição enzimática e benefícios terapêuticos potenciais.
Fórmula:C16H24N2O4
InChI:InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
Chave InChI:InChIKey=VGGGPCQERPFHOB-RDBSUJKOSA-N
SMILES:C([C@H]([C@@H](C(N[C@@H](CC(C)C)C(O)=O)=O)O)N)C1=CC=CC=C1
Sinónimos:- <span class="text-smallcaps">L</span>-Leucine, N-(3-amino-2-hydroxy-1-oxo-4-phenylbutyl)-, [S-(R*,S*)]-
- <span class="text-smallcaps">L</span>-Leucine, N-[(2S,3R)-3-amino-2-hydroxy-1-oxo-4-phenylbutyl]-
- Bestain
- Bestatin
- N-(3-amino-2-hydroxy-4-phenylbutanoyl)leucine
- N-[(2S,3R)-3-Amino-2-hydroxy-1-oxo-4-phenylbutyl]-<span class="text-smallcaps">L</span>-leucine
- N-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]-D-leucine
- N-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]-L-leucine
- N-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]leucine
- NSC 265489
- Nk 421
- L-Leucine, N-(3-amino-2-hydroxy-1-oxo-4-phenylbutyl)-, [S-(R*,S*)]-
- N-[(2S,3R)-3-Amino-2-hydroxy-1-oxo-4-phenylbutyl]-L-leucine
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16 produtos.
Bestatin
CAS:<p>Bestatin can indirectly act on monocytes by inhibiting Aminopeptidase B, which in turn inhibits the catabolism of tuftsin. Bestatin has also been shown to inhibit Leukotriene A4 hydrolase. It can directly stimulate lymphocytes through its fixation on the cell surface. The agent has been used in mul</p>Fórmula:C16H24N2O4Cor e Forma:White to pale cream, PowderPeso molecular:308.38[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine
CAS:Bestatin (or ubenimex), an antibiotic of natural origin, is a specific, competitive inhibitor of many aminopeptidases, though it does not inhibit aminopeptidase A. Due to its low toxicity it has been administered to cultured cells, animals and humans. Bestatin offered by Bachem has been obtained by chemical synthesis.Fórmula:C16H24N2O4Pureza:99.5%Cor e Forma:White PowderPeso molecular:308.38(2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido]-4-methylpentanoic acid
CAS:Fórmula:C16H24N2O4Pureza:98%Cor e Forma:SolidPeso molecular:308.3728Ref: IN-DA00370Q
1g132,00€5g223,00€10g532,00€25gA consultar50gA consultar100gA consultar10mg29,00€250gA consultar50mg34,00€100mg44,00€250mg68,00€N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine
CAS:Fórmula:C16H24N2O4Pureza:≥ 98.0%Cor e Forma:White powderPeso molecular:308.37Ubenimex Hydrochloride [for Biochemical Research]
CAS:Fórmula:C16H24N2O4·HClPureza:>97.0%(HPLC)Cor e Forma:White to Almost white powder to crystalPeso molecular:344.84Ubenimex
CAS:Fórmula:C16H24N2O4Pureza:>98.0%(HPLC)Cor e Forma:White to Almost white powder to crystalPeso molecular:308.38Bestatin free base
CAS:Bestatin free baseFórmula:C16H24N2O4Pureza:By hplc: >98% by area (Typical Value in Batch COA)Cor e Forma: white powderPeso molecular:308.37g/molBestatin
CAS:<p>Bestatin (Ubenimex) competitively inhibits many aminopeptidases. Bestatin is a microbial metabolite and dipeptide with immunomodulatory and antitumor effects.</p>Fórmula:C16H24N2O4Pureza:98% - 99.63%Cor e Forma:White Crystalline PowderPeso molecular:308.37Ubenimex - Bio-X ™
CAS:<p>Ubenimex is a protease inhibitor drug that is being studied for the treatment of acute myelocytic leukemia. This drug is an aminopeptidase N, B and leukotriene A4 hydrolase inhibitor. It is also used in the treatment of hypercholesterolaemia.</p>Fórmula:C16H24N2O4Pureza:Min. 95%Cor e Forma:PowderPeso molecular:308.37 g/molUbenimex
CAS:<p>Aminopeptidase N (CD13) inhibitor; immunomodulator</p>Fórmula:C16H24N2O4Pureza:Min. 98 Area-%Cor e Forma:White PowderPeso molecular:308.37 g/molUbenimex (Bestatin)
CAS:Ubenimex (Bestatin) is an enzyme inhibitor that belongs to the class of dpp-iv inhibitors. It is used as an antifungal agent and has been shown to be effective against Candida albicans, Cryptococcus neoformans, Aspergillus fumigatus, Trichophyton mentagrophytes, and Microsporum canis. Ubenimex (Bestatin) inhibits the synthesis of protein by binding to the 30S ribosomal subunit and blocking the peptidyl transferase activity of the 50S ribosomal subunit. This drug also has a cytostatic effect on cancer cells in vitro.Fórmula:C16H24N2O4Pureza:Min. 95%Peso molecular:308.37 g/molBestatin
CAS:Produto Controlado<p>Applications Bestatin is a competitive and specific inhibitor of leucine aminopeptidase, aminopeptidase B, and triamino peptidase.<br>References Umezawa, H., et al.: J. Antib., 29, 97 (1976); Poloz, Y., et al.: Eukaryotic Cell, 11, 545 (2012);<br></p>Fórmula:C16H24N2O4Cor e Forma:NeatPeso molecular:308.37
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![(2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido]-4-methylpentanoic acid](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA00370Q.jpg&w=3840&q=75)
![N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F7W%2Fthumb%2FGM3911.jpg&w=3840&q=75)
![Ubenimex Hydrochloride [for Biochemical Research]](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F3B%2Fthumb%2FB4000.jpg&w=3840&q=75)
