CAS 59-05-2

Metotrexato

Descrição:

Metotrexato é um potente antimetabólito e agente imunossupressor usado principalmente no tratamento de certos cânceres, doenças autoimunes e gravidezes ectópicas. Sua fórmula química é C20H22N8O5S, e apresenta uma estrutura de anel de pteridina, que é crucial para seu mecanismo de ação. Metotrexato funciona inibindo a enzima diidrofolato redutase, interrompendo assim a síntese de nucleotídeos e, em última análise, afetando a replicação do DNA e a divisão celular. Isso o torna particularmente eficaz contra células que se dividem rapidamente, como aquelas encontradas em tumores. Metotrexato é administrado de várias formas, incluindo comprimidos orais e soluções injetáveis, e sua farmacocinética pode variar com base na via de administração. O medicamento é conhecido por seus potenciais efeitos colaterais, que podem incluir distúrbios gastrointestinais, toxicidade hepática e supressão da medula óssea. Devido às suas propriedades imunossupressoras, o monitoramento cuidadoso é essencial durante o tratamento para gerenciar efeitos adversos e interações com outros medicamentos. O uso de Metotrexato em doses mais baixas para condições autoimunes destaca sua versatilidade em aplicações clínicas.

Fórmula: C₂₀H₂₂N₈O₅

InChI: InChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1

Chave InChI: InChIKey=FBOZXECLQNJBKD-ZDUSSCGKSA-N

SMILES: NC=1C2=C(N=CC(CN(C)C3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)N=C(N)N1

Sinónimos:

• (+)-4-Amino-10-Methylfolic Acid
• (+)-Amethopterin
• (2S)-2-[[4-[[(2,4-Diaminopteridin-6-yl)methyl]methylamino]benzoyl]amino]pentanedioic acid
• 4-Amino-1
• 4-Amino-4-Deoxy-N(Sup10
• 4-Amino-4-Deoxy-N(Sup10)Methylpteroylglutamic Acid
• 4-Amino-N 10-Methylpteroyl-L-Glutamic Acid
• 4-Amino-N10-methylfolic acid
• 4-Amino-N10-methylpteroylglutamic acid
• 4-Amino-N¹⁰-methylfolic acid
• 4-Amino-N¹⁰-methylpteroylglutamic acid
• <span class="text-smallcaps">L</span>-Amethopterin
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-
• <span class="text-smallcaps">L</span>-Methotrexate
• Amethopterine
• Antifolan
• Caditrex
• Cl 14377
• Emt 25299
• Emtexate
• Emthexate PF
• Emtrexate
• Folex
• Folex PFS
• Folitrax
• Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, <span class="text-smallcaps">L</span>-(+)-
• Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, L-(+)-
• Jylamvo
• L-(+)-Amethopterin
• L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-
• L-Methotrexate
• Ledertrexate
• Merex
• Metatrexan
• Methocel
• Methocip
• Methotrexat
• Methotrexat-Ebewe
• Methotrexate LPF
• Methoxtrexate
• Methylaminopterin
• Methylaminopterine
• Methylpteroylglutamate
• Methylpteroylglutamic Acid
• Metorex
• Metotrexato
• Mexate
• Mexate-AQ
• Mtx
• N-(P-(((2,4-Diamino-6-Pteridinyl)Methyl)Methylamino)Benzoyl)-L-Glutamic Acid
• N-[4-[[(2,4-Diamino-6-Pteridinyl)Methyl]Methylamino]Benzoyl]-L-Glutamic Acid
• N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-<span class="text-smallcaps">L</span>-glutamic acid
• N-[p-[[2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-<span class="text-smallcaps">L</span>-(+)-glutamic acid
• Nordimet
• Nsc 740
• Oncotrex
• R 9985
• Remtrex
• Rheumatrex
• Trexall
• Trilem

Methotrexate Hydrate

CAS: 133073-73-1, 59-05-2

Fórmula: C₂₀H₂₂N₈O₅·xH₂O

Pureza: >98.0%(T)(HPLC)

Cor e Forma: Light yellow to Brown powder to crystal

Peso molecular: 454.45 (as Anhydrous)

Ref: 3B-M1664

Methotrexate

CAS: 59-05-2

Methotrexate is used as s cell cycle arresting agent that inhibits DHFR. It is used in treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. It acts by inhibiting the metabolism of folic acid. Methotrexate is one of the most effective and widely use

Fórmula: C₂₀H₂₂N₈O₅

Cor e Forma: Yellow or yellow-orange, Powder or crystalline powder

Peso molecular: 454.45

Ref: 02-J63075

Methotrexate

CAS: 59-05-2

Cor e Forma: Neat

Ref: 61-FOR0040.00

METHOTREXATE RS

CAS: 59-05-2

METHOTREXATE RS

Fórmula: C₂₀H₂₂N₈O₅

Peso molecular: 454.4393

Ref: 41-ICRS0345

METHOTREXATE FOR PEAK IDENTIFICATION CRS

CAS: 59-05-2

METHOTREXATE FOR PEAK IDENTIFICATION CRS

Fórmula: C₂₀H₂₂N₈O₅

Peso molecular: 454.4393

Ref: 41-Y0000602

METHOTREXATE CRS

CAS: 59-05-2

METHOTREXATE CRS

Fórmula: C₂₀H₂₂N₈O₅

Cor e Forma: Crystalline Powder. Yellow. Orange. Powder.

Peso molecular: 454.4393

Ref: 41-M1000000

Methotrexate

CAS: 59-05-2

Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure

Fórmula: C₂₀H₂₂N₈O₅

Cor e Forma: Yellow Brown Orange Powder

Peso molecular: 454.17132

Ref: 45-1414003

(S)-2-(4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioic acid

CAS: 59-05-2

Fórmula: C₂₀H₂₂N₈O₅

Pureza: 97%

Cor e Forma: Solid

Peso molecular: 454.4393

Ref: IN-DA0039PY

Methotrexate

CAS: 59-05-2

Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR.

Fórmula: C₂₀H₂₂N₈O₅

Pureza: 96.84% - 99.91%

Cor e Forma: Orange-Brown Crystalline Powder Chemotherapy Drug That Interferes With Dna And Rna Synthesis

Peso molecular: 454.44

Ref: TM-T1485

Methotrexate

CAS: 59-05-2

Methotrexate

Pureza: ≥95%

Peso molecular: 454.44g/mol

Ref: 54-BUP17033

Methotrexate

CAS: 59-05-2

Methotrexate

Fórmula: C₂₀H₂₂N₈O₅

Pureza: By hplc: 98.13% (Typical Value in Batch COA)

Cor e Forma: yellow solid

Peso molecular: 454.43927g/mol

Ref: 54-BIM0130

Methotrexate

CAS: 59-05-2

Fórmula: C₂₀H₂₂N₈O₅

Cor e Forma: Yellow Solid

Peso molecular: 454.45

Ref: 4Z-M-701

Methotrexate 1.0 mg/ml in Dimethyl Sulfoxide

CAS: 59-05-2

Cor e Forma: Single Solution

Ref: 61-AMP0040.00-29

Methotrexate

Produto Controlado

CAS: 59-05-2

Fórmula: C₂₀H₂₂N₈O₅

Cor e Forma: Neat

Peso molecular: 454.44

Ref: 86-MM0040.00

Methotrexate

Produto Controlado

CAS: 59-05-2

Fórmula: C₂₀H₂₂N₈O₅

Cor e Forma: Neat

Peso molecular: 454.44

Ref: 04-C15056900

Methotrexate Heptaglutamate Trifluoroacetate

CAS: 59-05-2

Fórmula: C₅₀H₆₄N₁₄O₂₃·C₂HF₃O₂

Peso molecular: 1229.14

Ref: 4Z-M-7026

Methotrexate RS

CAS: 59-05-2

Cor e Forma: From Yellow To Brownish Orange Solid Powder

Ref: 2K-1167000021

Methotrexate (1 mg/mL in Methanol with 0.1N NaOH)

CAS: 59-05-2

Fórmula: C₂₀H₂₂N₈O₅

Cor e Forma: Single Solution

Peso molecular: 454.44

Ref: TR-KIT0310

Methotrexate

CAS: 59-05-2

Stability Hygroscopic
Applications A Folic acid antagonist. Used as a antineoplastic and antirheumatic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958), Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985),

Fórmula: C₂₀H₂₂N₈O₅

Cor e Forma: Yellow To Dark Yellow

Peso molecular: 454.44

Ref: TR-M260675

Methotrexate Heptaglutamate Trifluoroacetate

Produto Controlado

CAS: 59-05-2

Fórmula: C₅₀H₆₄N₁₄O₂₃xC₂HF₃O₂

Cor e Forma: Neat

Peso molecular: 1229.12

Ref: TR-M260690

Methotrexate-d3 Heptaglutamate Trifluoroacetate

Produto Controlado

CAS: 432545-63-6, 59-05-2

Fórmula: C₅₀H₆₁D₃N₁₄O₂₃xC₂HF₃O₂

Cor e Forma: Neat

Peso molecular: 1232.142

Ref: TR-M260692

Methotrexate

CAS: 59-05-2

Methotrexate is a chemotherapeutic and immunosuppressive medication, which is a synthetic analog of folic acid. Its source is through chemical synthesis, mimicking the structure of dihydrofolate in order to exert its effects. Methotrexate acts primarily by inhibiting the enzyme dihydrofolate reductase (DHFR), leading to a decrease in tetrahydrofolate production. This disruption in folate metabolism results in the inhibition of DNA, RNA, and protein synthesis, which affects rapidly dividing cells.Methotrexate is employed broadly in clinical oncology as an antineoplastic agent, particularly in the treatment of leukemias, lymphomas, breast cancer, and osteosarcoma. Additionally, it serves as a cornerstone for managing autoimmune diseases such as rheumatoid arthritis and psoriasis, where it helps modulate the aberrant immune response. The dual role of Methotrexate in oncology and immunosuppression underscores its versatility and critical importance in therapeutic regimens. However, its use demands careful monitoring due to potential adverse effects on non-cancerous cells and organ systems, necessitating precise dosage management and patient evaluation.

Fórmula: C₂₀H₂₂N₈O₅

Cor e Forma: Yellow Powder

Peso molecular: 454.44 g/mol

Ref: 3D-FA25165

Methotrexate

CAS: 59-05-2

Pureza: 97%

Peso molecular: 454.45

Ref: 10-F036492