CAS 59-05-2

Metotrexato

Descrição:

Metotrexato é um potente antimetabólito e agente imunossupressor usado principalmente no tratamento de certos cânceres, doenças autoimunes e gravidezes ectópicas. Sua fórmula química é C20H22N8O5S, e apresenta uma estrutura de anel de pteridina, que é crucial para seu mecanismo de ação. Metotrexato funciona inibindo a enzima diidrofolato redutase, interrompendo assim a síntese de nucleotídeos e, em última análise, afetando a replicação do DNA e a divisão celular. Isso o torna particularmente eficaz contra células que se dividem rapidamente, como aquelas encontradas em tumores. Metotrexato é administrado de várias formas, incluindo comprimidos orais e soluções injetáveis, e sua farmacocinética pode variar com base na via de administração. O medicamento é conhecido por seus potenciais efeitos colaterais, que podem incluir distúrbios gastrointestinais, toxicidade hepática e supressão da medula óssea. Devido às suas propriedades imunossupressoras, o monitoramento cuidadoso é essencial durante o tratamento para gerenciar efeitos adversos e interações com outros medicamentos. O uso de Metotrexato em doses mais baixas para condições autoimunes destaca sua versatilidade em aplicações clínicas.

Fórmula: C₂₀H₂₂N₈O₅

InChI: InChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1

Chave InChI: InChIKey=FBOZXECLQNJBKD-ZDUSSCGKSA-N

SMILES: NC=1C2=C(N=CC(CN(C)C3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)N=C(N)N1

Sinónimos:

• (+)-4-Amino-10-Methylfolic Acid
• (+)-Amethopterin
• (2S)-2-[[4-[[(2,4-Diaminopteridin-6-yl)methyl]methylamino]benzoyl]amino]pentanedioic acid
• 4-Amino-1
• 4-Amino-4-Deoxy-N(Sup10
• 4-Amino-4-Deoxy-N(Sup10)Methylpteroylglutamic Acid
• 4-Amino-N 10-Methylpteroyl-L-Glutamic Acid
• 4-Amino-N10-methylfolic acid
• 4-Amino-N10-methylpteroylglutamic acid
• 4-Amino-N¹⁰-methylfolic acid
• 4-Amino-N¹⁰-methylpteroylglutamic acid
• <span class="text-smallcaps">L</span>-Amethopterin
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-
• <span class="text-smallcaps">L</span>-Methotrexate
• Amethopterine
• Antifolan
• Caditrex
• Cl 14377
• Emt 25299
• Emtexate
• Emthexate PF
• Emtrexate
• Folex
• Folex PFS
• Folitrax
• Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, <span class="text-smallcaps">L</span>-(+)-
• Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, L-(+)-
• Jylamvo
• L-(+)-Amethopterin
• L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-
• L-Methotrexate
• Ledertrexate
• Merex
• Metatrexan
• Methocel
• Methocip
• Methotrexat
• Methotrexat-Ebewe
• Methotrexate LPF
• Methoxtrexate
• Methylaminopterin
• Methylaminopterine
• Methylpteroylglutamate
• Methylpteroylglutamic Acid
• Metorex
• Metotrexato
• Mexate
• Mexate-AQ
• Mtx
• N-(P-(((2,4-Diamino-6-Pteridinyl)Methyl)Methylamino)Benzoyl)-L-Glutamic Acid
• N-[4-[[(2,4-Diamino-6-Pteridinyl)Methyl]Methylamino]Benzoyl]-L-Glutamic Acid
• N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-<span class="text-smallcaps">L</span>-glutamic acid
• N-[p-[[2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-<span class="text-smallcaps">L</span>-(+)-glutamic acid
• Nordimet
• Nsc 740
• Oncotrex
• R 9985
• Remtrex
• Rheumatrex
• Trexall
• Trilem

Methotrexate

CAS: 59-05-2

(S)-2-(4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioic acid

Fórmula: C₂₀H₂₂N₈O₅

Pureza: 99% (contain ~10%water)

Peso molecular: 454.44

Ref: IN-DG43028

Methotrexate RS

CAS: 59-05-2

Cor e Forma: From Yellow To Brownish Orange Solid Powder

Ref: 2K-116700002

Methotrexate (1.0mg/mL in Methanol with 0.1N NaOH)

CAS: 59-05-2

Fórmula: C₂₀H₂₂N₈O₅

Ref: TR-KIT0310-1ML

Methotrexate

CAS: 59-05-2

Methotrexate is a chemotherapeutic and immunosuppressive medication, which is a synthetic analog of folic acid. Its source is through chemical synthesis, mimicking the structure of dihydrofolate in order to exert its effects. Methotrexate acts primarily by inhibiting the enzyme dihydrofolate reductase (DHFR), leading to a decrease in tetrahydrofolate production. This disruption in folate metabolism results in the inhibition of DNA, RNA, and protein synthesis, which affects rapidly dividing cells.Methotrexate is employed broadly in clinical oncology as an antineoplastic agent, particularly in the treatment of leukemias, lymphomas, breast cancer, and osteosarcoma. Additionally, it serves as a cornerstone for managing autoimmune diseases such as rheumatoid arthritis and psoriasis, where it helps modulate the aberrant immune response. The dual role of Methotrexate in oncology and immunosuppression underscores its versatility and critical importance in therapeutic regimens. However, its use demands careful monitoring due to potential adverse effects on non-cancerous cells and organ systems, necessitating precise dosage management and patient evaluation.

Fórmula: C₂₀H₂₂N₈O₅

Cor e Forma: Yellow Powder

Peso molecular: 454.44 g/mol

Ref: 3D-FA25165

Methotrexate in Methanol(0.1mol/L NaOH )

CAS: 59-05-2

Methanol(0.1mol/L NaOH )

Fórmula: C₂₀H₂₂N₈O₅

Cor e Forma: Solid

Peso molecular: 454.4

Ref: BE-MU-7154YZ-1000

Methotrexate

CAS: 59-05-2

Fórmula: C₂₀H₂₂N₈O₅

Cor e Forma: Solid

Peso molecular: 454.4

Ref: BE-MU-7154

Methotrexate

CAS: 59-05-2

Fórmula: C₂₀H₂₂N₈O₅

Cor e Forma: Solid

Peso molecular: 454.4

Ref: BE-RMCM148000

Methotrexate-[13C,d3]

CAS: 59-05-2

Fórmula: C₂₀H₂₂N₈O₅

Cor e Forma: Solid

Peso molecular: 454.4

Ref: BE-MCD-7204

Methotrexate-d3 Heptaglutamate Trifluoroacetate

Produto Controlado

CAS: 432545-63-6, 59-05-2

Fórmula: C₅₀H₆₁D₃N₁₄O₂₃xC₂HF₃O₂

Cor e Forma: Neat

Peso molecular: 1232.142

Ref: TR-M260692

Methotrexate

CAS: 59-05-2

Fórmula: C₂₀H₂₂N₈O₅

Peso molecular: 454.45

Ref: ST-EA-CP-M12000

Methotrexate RS

CAS: 59-05-2

Cor e Forma: From Yellow To Brownish Orange Solid Powder

Ref: 2K-1167000021