CAS 59973-80-7

(Z)-5-Fluoro-2-metil-1-[4-(metilsulfonil)benzilideno]-1H-indeno-3-ácido acético

Descrição:

(Z)-5-Fluoro-2-metil-1-[4-(metilsulfonil)benzilideno]-1H-indeno-3-ácido acético, com o número CAS 59973-80-7, é um composto orgânico sintético caracterizado por suas características estruturais únicas. Contém um átomo de flúor, um grupo metila e um grupo metilsulfonila, contribuindo para sua potencial atividade biológica. A estrutura central de indeno é notável por suas propriedades aromáticas, que podem influenciar a reatividade do composto e suas interações com alvos biológicos. Este composto provavelmente exibirá lipofilicidade moderada a alta devido às suas regiões hidrofóbicas, o que pode afetar sua solubilidade e permeabilidade em sistemas biológicos. A presença do grupo funcional ácido acético sugere potencial para ionização a pH fisiológico, impactando sua farmacocinética. Além disso, a configuração (Z) indica um arranjo geométrico específico ao redor da dupla ligação, o que pode influenciar significativamente a atividade biológica do composto e suas interações. No geral, este composto pode ser de interesse na química medicinal, particularmente no desenvolvimento de fármacos que visam vias biológicas específicas.

Fórmula: C₂₀H₁₇FO₄S

InChI: InChI=1S/C20H17FO4S/c1-12-17(9-13-3-6-15(7-4-13)26(2,24)25)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-

Chave InChI: InChIKey=MVGSNCBCUWPVDA-MFOYZWKCSA-N

SMILES: C(C(O)=O)C=1C=2C(/C(=C\C3=CC=C(S(C)(=O)=O)C=C3)/C1C)=CC=C(F)C2

Sinónimos:

• (1Z)-5-Fluoro-2-methyl-1-[[4-(methylsulfonyl)phenyl]methylene]-1H-indene-3-acetic acid
• 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-[[4-(methylsulfonyl)phenyl]methylene]-, (1Z)-
• 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-[[4-(methylsulfonyl)phenyl]methylene]-, (Z)-
• Aposulind
• Aptosyn
• Exisulind
• Fgn-1
• Prevatac(former Brand Name)
• Prevatec
• Sulindac sulfone
• cis-5-Fluoro-2-methyl-1-[p-methylsulfonylbenzylidenyl]indene-3-acetic acid
• 5-Fluoro-2-methyl-1-[(Z)-4-(methylsulfonyl)benzylidene]-1H-indene-3-acetic acid
• Unii-K619iig2R9
• (Z)-5-Fluoro-2-Methyl-1-[[4-(Methylsulfonyl)phenyl]Methylene]-1H-indene-3-acetic Acid
• APTOSYN/EXISULIND
• Ccris 7242
• Sulindac EP Impurity B (Sulindac USP Related Compound B, Sulindac Sulfone)
• Sulindac Impurity 2（Sulindac EP Impurity B）
• (Z)-Sulindac Sulfone
• Sulindac EP Impurity B/ Sulindac Related Compound B ((Z)-Sulindac Sulfone)
• (Z)-5-FLUORO-2-METHYL-1[P-(METHYLSULFONYL)BENZYLIDENE]INDENE-3-ACETIC ACID
• Sulindac Related Compound B ((Z)-2-{5-fluoro-2-methyl-1-[4-(methylsulfonyl)benzylidene]-1H-inden-3- (1642020)
• Sulindac EP Impurity B (Sulindac Sulfone)
• Sulindac USP Related Compound B

Sulindac Related Compound B ((Z)-2-{5-fluoro-2-methyl-1-[4-(methylsulfonyl)benzylidene]-1H-inden-3-yl}acetic acid)

CAS: 59973-80-7

Other aromatic organo-sulfur compounds (excluding pesticides)

Fórmula: C₂₀H₁₇FO₄S

Cor e Forma: Yellow Crystalline Powder

Peso molecular: 372.08316

Ref: 45-1642020

1H-Indene-3-acetic acid,5-fluoro-2-methyl-1-[[4-(methylsulfonyl)phenyl]methylene]-, (1Z)-

CAS: 59973-80-7

Fórmula: C₂₀H₁₇FO₄S

Pureza: 97%

Cor e Forma: Solid

Peso molecular: 372.4100

Ref: IN-DA00EC0N

Exisulind

CAS: 59973-80-7

Exisulind

Pureza: ≥95%

Peso molecular: 372.41g/mol

Ref: 54-BUP06388

Sulindac EP Impurity B (Sulindac USP Related Compound B, Sulindac Sulfone)

CAS: 59973-80-7

Fórmula: C₂₀H₁₇FO₄S

Cor e Forma: Yellow Solid

Peso molecular: 372.41

Ref: 4Z-S-294

Sulindac EP Impurity B

Produto Controlado

CAS: 59973-80-7

Fórmula: C₂₀H₁₇FO₄S

Cor e Forma: Neat

Peso molecular: 372.41

Ref: 86-MM0624.02

(Z)-Sulindac Sulfone

CAS: 59973-80-7

Stability Hygroscopic
Applications An active metabolite of Sulindac. Inducer of apoptosis independent of cyclooxygenase inhibition. Inhibits cell growth by inducing apoptosis.
References Piazza, G.A., et al.: Cancer Res., 55, 3310 (1995)

Fórmula: C₂₀H₁₇FO₄S

Cor e Forma: Neat

Peso molecular: 372.41

Ref: TR-S699225

Sulindac Sulfone-d6

Produto Controlado

CAS: 59973-80-7

Applications Labelled analogue of Sulindac Sulfone, an active metabolite of Sulindac. Inducer of apoptosis independent of cyclooxygenase inhibition. Inhibits cell growth by inducing apoptosis.
References Piazza, G.A. et al.: Cancer Res., 55, 3310 (1995);

Fórmula: C₂₀H₁₁D₆FO₄S

Cor e Forma: Neat

Peso molecular: 378.45

Ref: TR-S699227

Sulindac sulfone

CAS: 59973-80-7

Sulindac sulfone is a nonsteroidal anti-inflammatory drug that belongs to the class of sulfones. It has been shown to inhibit the mcl-1 protein, which is involved in the mitochondrial apoptosis pathway. Sulindac sulfone inhibits prostaglandin E2 (PGE2) levels and mitochondrial membrane potential in vitro assays. Sulindac sulfone also has inhibitory properties against a number of enzymes including cyclooxygenase-2 (COX-2), lipoxygenases, phospholipases A2, and thromboxane synthase. These properties are responsible for its anti-inflammatory effects. Sulindac sulfone shows minimal toxicity due to its low bioavailability and lack of liver metabolism. This drug has been shown to have anticancer activity as well as an ability to inhibit infectious diseases such as Leishmania major and Helicobacter pylori.

Fórmula: C₂₀H₁₇FO₄S

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 372.41 g/mol

Ref: 3D-FS27971

Sulindac EP Impurity B

CAS: 59973-80-7

Fórmula: C₂₀H₁₇FO₄S

Peso molecular: 372.41

Ref: ST-EA-CP-S108002

Exisulind

CAS: 59973-80-7

Exisulind (CP248) triggers apoptosis via PKG activation, shows antitumor effects, and inhibits growth in various rodent cancer models.

Fórmula: C₂₀H₁₇FO₄S

Pureza: 97.94%

Cor e Forma: Solid

Peso molecular: 372.41

Ref: TM-T24051