CAS 60-81-1

Floridzina

Descrição:

Floridzina, com o número CAS 60-81-1, é um glicosídeo flavonoide que ocorre naturalmente, encontrado principalmente na casca de macieiras e outras plantas. É caracterizado por sua estrutura química, que consiste em uma espinha dorsal de florétina ligada a uma molécula de glicose. Floridzina exibe várias propriedades biológicas notáveis, incluindo efeitos antioxidantes, anti-inflamatórios e potenciais efeitos anti-diabéticos, pois pode inibir a reabsorção de glicose nos rins. Este composto também é conhecido por seu papel nos mecanismos de defesa das plantas e tem sido estudado por seus potenciais benefícios à saúde em humanos, particularmente em relação a distúrbios metabólicos. Em termos de propriedades físicas, Floridzina é tipicamente um pó cristalino branco a amarelo pálido, solúvel em água e solventes orgânicos. Sua estabilidade pode ser influenciada por fatores como pH e temperatura. Devido às suas diversas atividades biológicas, Floridzina despertou interesse tanto na pesquisa farmacológica quanto na indústria alimentícia, particularmente no contexto de alimentos funcionais e suplementos dietéticos.

Fórmula: C₂₁H₂₄O₁₀

InChI: InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1

Chave InChI: InChIKey=IOUVKUPGCMBWBT-QNDFHXLGSA-N

SMILES: C(CCC1=CC=C(O)C=C1)(=O)C2=C(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)C=C(O)C=C2O

Sinónimos:

• 1-Propanone, 1-[2-(β-<span class="text-smallcaps">D</span>-glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-
• 1-[2-(β-<span class="text-smallcaps">D</span>-Glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone
• 1-[2-(β-D-Glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone
• 2'-(β-D-Glucopyranosyloxy)-4',6'-dihydroxy-3-(4-hydroxyphenyl)propiophenon
• 2'-(β-D-glucopiranosiloxi)-4',6'-dihidroxi-3-(4-hidroxifenil)propiofenona
• 2'-(β-D-glucopyrannosyloxy)-4',6'-dihydroxy-3-(4-hydroxyphenyl)propiophenone
• 2'-(β-D-glucopyranosyloxy)-4',6'-dihydroxy-3-(4-hydroxyphenyl)propiophenone
• Dihydrochalcone 2′-β-<span class="text-smallcaps">D</span>-glucopyranoside
• Floridzin
• Nsc 2833
• Phloretin 2'-O-glucoside
• Phloretin 2'-glucoside
• Phloretin 2′-O-β-<span class="text-smallcaps">D</span>-glucopyranoside
• Phloretin 2′-β-<span class="text-smallcaps">D</span>-Glucoside
• Phloretin glucoside
• Phlorhizin
• Phloridzin
• Phloridzosid
• Phlorizin
• Phlorizine
• Phlorizoside
• Phlorrhizin
• 1-Propanone, 1-[2-(β-D-glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-
• 3,5-dihydroxy-2-[3-(4-hydroxyphenyl)propanoyl]phenyl β-D-glucopyranoside
• 3,5-dihydroxy-2-[3-(4-hydroxyphenyl)propanoyl]phenyl hexopyranoside
• Phlorizin dihydrate

Phlorizin

CAS: 60-81-1, 7061-54-3

Fórmula: C₂₁H₂₄O₁₀

Pureza: >97.0%(T)(HPLC)

Cor e Forma: White to Light yellow to Light orange powder to crystal

Peso molecular: 436.41

Ref: 3B-P0248

Phloridzin

CAS: 60-81-1

Phloridzin analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Fórmula: C₂₁H₂₄O₁₀

Pureza: (HPLC) ≥99%

Cor e Forma: Powder

Peso molecular: 436.42

Ref: 11-1361S

Phlorizin

CAS: 60-81-1

Phlorizin

Pureza: 98%

Peso molecular: 436.41g/mol

Ref: 54-OR1029277

Phlorizin

CAS: 60-81-1

Phlorizin

Pureza: ≥98%

Peso molecular: 436.41g/mol

Ref: 54-BUP18505

Phlorizin

CAS: 60-81-1

Pureza: 95.0%

Cor e Forma: Solid

Peso molecular: 436.4129943847656

Ref: 10-F079095

Phloridzin

CAS: 60-81-1

Fórmula: C₂₁H₂₄O₁₀

Pureza: 95%~99%

Peso molecular: 436.413

Ref: BP-BP1089

Phlorizin

CAS: 60-81-1

Phlorizin (Phloridzin) is a non-selective SGLT inhibitor found in apple, for hSGLT1( Ki=300 nM) and hSGLT2( Ki=39 nM) .

Fórmula: C₂₁H₂₄O₁₀

Pureza: 99.73% - 99.77%

Cor e Forma: Solid Crystalline

Peso molecular: 436.41

Ref: TM-T2922

Phloridzin

CAS: 60-81-1

Fórmula: C₂₁H₂₄O₁₀

Pureza: ≥ 98.0%

Cor e Forma: Off-white to light yellow powder

Peso molecular: 436.41

Ref: 7W-GC6883

Phloridzin

CAS: 60-81-1

Natural glycoside

Fórmula: C₂₁H₂₄O₁₀

Pureza: ≥ 98.0 % (HPLC)

Cor e Forma: Powder

Peso molecular: 436.42

Ref: 5G-80513

Phloridzin

Produto Controlado

CAS: 60-81-1

Applications It is a dihydrochalcone occurring in all parts of the apple tree except the mature fruit. Once thought to occur in pear, plum, cherry trees and other Rosaceae. Inhibitor of Na+-glucose cotransporters (SGLT). inhibits both SGLT1 and SGLT2 with low therapeutic selectivity. Cytotoxic to Breast Cancer cells with potent antioxidant and antibacterial activity. Produces renal glycosuria and blocks intestinal glucose absorption. Normalizes insulin sensitivity in diabetic rats.
References Moelwyn-Hughes EA, 1930. J Gen Physiol. Jul 20;13(6):807-17.Chang-Ik, 2016. Molecules, 21, 1136Fernando W, et al. 2016. Carcinogenesis. 2016 Oct;37(10):1004-13

Fórmula: C₂₁H₂₄O₁₀

Cor e Forma: Neat

Peso molecular: 436.41

Ref: TR-P339500

Phloridzin

CAS: 60-81-1

Phloridzin is a flavonoid glycoside, which is primarily sourced from apple trees and other members of the Rosaceae family. It is naturally found in the bark, roots, and other parts of the plant. The mode of action of phloridzin involves its function as an inhibitor of the sodium-glucose transporters (SGLT1 and SGLT2). By blocking these transporters, phloridzin prevents the reabsorption of glucose in the renal tubules, thus promoting the excretion of glucose through urine.

Fórmula: C₂₁H₂₄O₁₀

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 436.41 g/mol

Ref: 3D-MP08132