CAS 61-72-3

Cloxacilina

Descrição:

Cloxacilina é um antibiótico penicilínico semissintético que é usado principalmente para tratar infecções causadas por estafilococos produtores de penicilinase. É caracterizado por sua estrutura de beta-lactama, que é essencial para sua atividade antibacteriana. Cloxacilina é eficaz contra uma variedade de bactérias Gram-positivas, particularmente Staphylococcus aureus, e é resistente à degradação por certas beta-lactamases, tornando-se uma opção valiosa no tratamento de infecções resistentes. O composto é tipicamente administrado por via oral ou intravenosa e é conhecido por seu perfil de toxicidade relativamente baixo. Sua farmacocinética inclui boa absorção do trato gastrointestinal, embora os alimentos possam afetar sua biodisponibilidade. Cloxacilina é metabolizado no fígado e excretado principalmente pelos rins. Efeitos colaterais comuns podem incluir distúrbios gastrointestinais, reações alérgicas e, em casos raros, efeitos mais graves, como toxicidade hepática. Assim como com todos os antibióticos, é crucial usar Cloxacilina de forma judiciosa para prevenir o desenvolvimento de resistência a antibióticos.

Fórmula: C₁₉H₁₈ClN₃O₅S

InChI: InChI=1S/C19H18ClN3O5S/c1-8-11(12(22-28-8)9-6-4-5-7-10(9)20)15(24)21-13-16(25)23-14(18(26)27)19(2,3)29-17(13)23/h4-7,13-14,17H,1-3H3,(H,21,24)(H,26,27)/t13-,14+,17-/m1/s1

Chave InChI: InChIKey=LQOLIRLGBULYKD-JKIFEVAISA-N

SMILES: N(C(=O)C=1C(=NOC1C)C2=C(Cl)C=CC=C2)[C@H]3[C@@]4(N([C@@H](C(O)=O)C(C)(C)S4)C3=O)[H]

Sinónimos:

• (2S,5R,6R)-6-({[3-(2-chlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• (2S,5R,6R)-6-[[[3-(2-Chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• (3-(o-Chlorophenyl)-5-methyl-4-isoxazolyl)penicillin
• 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(((3-(2-chlorophenyl)-5-methyl-4-isoxazolyl)carbonyl)amino)-3,3-dimethyl-7-oxo-, (2S-(2alpha,5alpha,6beta))-
• 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(3-(O-chlorophenyl)-5-methyl-4-isoxazolecarboxamido)-3,3-dimethyl-7-oxo-
• 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(3-(o-chlorophenyl)-S-methyl-4-isoxazolecarboxamido)-3,3-dimethyl-7-oxo-
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimet hyl-7-oxo-, (2S,5R,6R)-
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)-
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, [2S-(2α,5α,6β)]-
• 6-(((3-(2-Chlorophenyl)-5-methyl-4-isoxazolyl)carbonyl)amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid
• 6-(3-(o-Chlorophenyl)-5-methyl-4-isoxazolecarboxamido)penicillanic acid
• 6-(3-o-Chlorophenyl-5-methylisoxazol-4-ylamido) penicillanic acid
• 6-(5-Methyl-3-o-chlorophenylisoxazole-4-carboxamido) penicillanic acid
• 6-[3-(o-Chlorophenyl)-5-methyl-4-isoxazolecarboxamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• 6-[3-(o-Chlorophenyl)-5-methyl-4-isoxazolylcarboxamido]penicillanic acid
• Brl 1621
• Clossacillina
• Clossacillina [DCIT]
• Cloxacilina
• Cloxacilina [INN-Spanish]
• Cloxacillin [INN:BAN]
• Cloxacilline
• Cloxacilline [INN-French]
• Cloxacillinum
• Cloxacillinum [INN-Latin]
• Hsdb 3042
• Methocillin S
• Methylchlorphenylisoxazoryl-penicillin
• Orbenin Extra Dry Cow
• Syntarpen
• Unii-O6X5Qgc2Vb

Cloxacillin Sodium Salt Monohydrate

CAS: 61-72-3, 642-78-4, 7081-44-9

Fórmula: C₁₉H₁₇ClN₃NaO₅S·H₂O

Pureza: >98.0%(HPLC)

Cor e Forma: White to Orange to Green powder to crystaline

Peso molecular: 475.88

Ref: 3B-C2244

Cloxacillin 1000 µg/mL in Acetonitrile

Produto Controlado

CAS: 61-72-3

Fórmula: C₁₉H₁₈ClN₃O₅S

Cor e Forma: Single Solution

Peso molecular: 435.8813

Ref: 04-A11692090AL-1000

Cloxacillin

CAS: 61-72-3

Cloxacillin, a β-lactamase inhibitor, tackles S. aureus inflammation and has an IC50 of 0.04 µM.

Fórmula: C₁₉H₁₈ClN₃O₅S

Cor e Forma: Solid

Peso molecular: 435.88

Ref: TM-T73058

Cloxacilline-13c4

CAS: 61-72-3

Cloxacillin is a sulfa drug that inhibits bacterial growth by binding to the 50S ribosomal subunit. It inhibits the synthesis of bacterial cell walls by binding to dextran sulfate and polymerase chain. Cloxacillin has been shown to have experimental solubility data in various biological samples, such as human serum and wastewater treatment. Cloxacillin has also been shown to be effective against Streptococcus pyogenes (Group A streptococci) and Staphylococcus aureus, which are two common causes of infectious diseases. Cloxacillin may be used in combination with vancomycin therapy or benzalkonium chloride for these infections.

Fórmula: C₁₉H₁₈ClN₃O₅S

Pureza: Min. 95%

Peso molecular: 435.88 g/mol

Ref: 3D-FC175020

Oxacillin EP Impurity E

CAS: 61-72-3

Fórmula: C₁₉H₁₈ClN₃O₅S

Peso molecular: 435.88

Ref: ST-EA-CP-O58005