CAS 6104-71-8

N-desmetilclozapina

Descrição:

N-desmetilclozapina, com o número CAS 6104-71-8, é um composto químico que serve como um metabolito da clozapina, um medicamento antipsicótico atípico usado principalmente para tratar a esquizofrenia. Este composto é caracterizado por sua modificação estrutural, onde um grupo metila é removido da molécula de clozapina, resultando em propriedades farmacológicas alteradas. N-desmetilclozapina exibe afinidade por vários receptores de neurotransmissores, incluindo receptores de dopamina e serotonina, o que pode contribuir para seus efeitos terapêuticos e efeitos colaterais. Geralmente é menos potente do que a clozapina em si, mas ainda pode influenciar o sistema nervoso central. O composto é tipicamente estudado no contexto da farmacocinética e farmacodinâmica, particularmente em relação ao seu papel na eficácia e no perfil de segurança do tratamento com clozapina. Além disso, entender suas características é crucial para monitorar interações medicamentosas e respostas individuais dos pacientes em ambientes clínicos. Assim como muitos metabolitos, a atividade biológica e o perfil de segurança de N-desmetilclozapina são importantes para otimizar estratégias terapêuticas no cuidado psiquiátrico.

Fórmula: C₁₇H₁₇ClN₄

InChI: InChI=1/C17H17ClN4/c18-12-5-6-15-16(11-12)21-17(22-9-7-19-8-10-22)13-3-1-2-4-14(13)20-15/h1-6,11,19,21H,7-10H2

Chave InChI: InChIKey=JNNOSTQEZICQQP-UHFFFAOYSA-N

SMILES: ClC=1C=C2N=C(C=3C(NC2=CC1)=CC=CC3)N4CCNCC4

Sinónimos:

• 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(1-piperazinyl)-
• 8-Chloro-11-(1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine
• 8-chloro-11-(piperazin-1-yl)-10H-dibenzo[b,e][1,4]diazepine
• Acp 104
• Demethylclozapine
• Desmethylclozapine
• N-Demethylclozapine
• Norclozapine
• N-Desmethylclozapine
• N-Desmethylclozapine
• 8-Chloro-11-(piperazin-1-yl)-5H-dib
• 8-Chloro-11-piperazinyl-5H-dibenzo[b,e][1,4]diazepine, Norclozapine, Normethylclozapine
• Norclozapine (ACP-104)
• Clozapine EP IMpurity C
• N-Desmethyl Clozapine-d8 hydrochloride
• NORCLOZAPINE; DESMETHYLCLOZAPINE; NORMETHYLCLOZAPINE
• N-Desmethylclozapine solution
• Clozapine EP Impurity C
• Clozapine impurity 3/Clozapine EP Impurity C/Clozapine impurity A (USP)/8-chloro-11-(piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
• 8-CHLORO-11-1[1-PIPERAZINYL)-5H-DIBENZO[B,E][1,4]DIAZEPINE
• Clozapine EP Impurity C Q: What is the storage condition of
• Clozapine Impurity 3(Clozapine EP Impurity C)
• Desmethylclozapine (Norclozapine)
• CLOZAPINE, NORMETHYL(NORMETHYLCLOZAPINE, NOR-CLOZAPINE, DESMETHYLC
• Clozapine EP Impurity C Q: What are the applications of
• Norclozapine Solution, 100ppm
• Clozapine EP Impurity C (N-Desmethyl Clozapine)
• Clozapine EP Impurity C Q: What is the CAS Number of
• 3-chloro-6-piperazin-1-yl-5H-benzo[b][1,4]benzodiazepine
• Normethylclozapine
• 8-Chloro-11-(piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
• Clozapine EP Impurity CQ: What is

Desmethylclozapine (Norclozapine) 1.0 mg/ml in Methanol

CAS: 6104-71-8

Cor e Forma: Single Solution

Ref: 61-AMP0480.03-01

Desmethylclozapine (Norclozapine)

CAS: 6104-71-8

Cor e Forma: Neat

Ref: 61-FOR0480.03

Clozapine EP Impurity C

CAS: 6104-71-8

Fórmula: C₁₇H₁₇ClN₄

Cor e Forma: Yellow Solid

Peso molecular: 312.80

Ref: 4Z-C-1416

N-Desmethylclozapine

CAS: 6104-71-8

Fórmula: C₁₇H₁₇ClN₄

Pureza: ≥ 97.0%

Cor e Forma: Yellow powder

Peso molecular: 312.80

Ref: 7W-GP9518

N-Desmethylclozapine

CAS: 6104-71-8

N-Desmethylclozapine

Pureza: ≥95%

Peso molecular: 312.8g/mol

Ref: 54-BUP10018

N-Desmethylclozapine

CAS: 6104-71-8

Fórmula: C₁₇H₁₇ClN₄

Pureza: >95.0%(GC)

Cor e Forma: White to Yellow powder to crystal

Peso molecular: 312.80

Ref: 3B-D5844

8-Chloro-11-(piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine

Produto Controlado

CAS: 6104-71-8

Fórmula: C₁₇H₁₇ClN₄

Cor e Forma: Neat

Peso molecular: 312.80

Ref: 86-MM0480.03

N-Desmethylclozapine

CAS: 6104-71-8

N-Desmethylclozapine: 5-HT2C antagonist (IC50: 7.1 nM), dopamine D4 antagonist, δ-opioid agonist.

Fórmula: C₁₇H₁₇ClN₄

Pureza: 97.25% - 99.83%

Cor e Forma: Yellow Crystalline Solid

Peso molecular: 312.8

Ref: TM-T5158

Clozapine EP Impurity C HCl Salt

CAS: 6104-71-8

Fórmula: C₁₇H₁₇ClN₄·HCl

Cor e Forma: Yellow Solid

Peso molecular: 312.80 36.46

Ref: 4Z-C-144

Clozapine EP Impurity C

CAS: 6104-71-8

Fórmula: C₁₇H₁₇ClN₄

Peso molecular: 312.80

Ref: ST-EA-CP-C63003

N-Desmethyl Clozapine

Produto Controlado

CAS: 6104-71-8

Applications N-Desmethyl Clozapine is a metabolite of Clozapine (C587500). N-Desmethyl Clozapine is a potent, allosteric agonist at human M1 receptors and is able to potentiate hippocampal NMDA receptor currents through M1 receptor activation.
References Sur, C., et al.: Proc. Nat. Acad. Sci. U. S. A., 100, 13674 (2003); Kuoppamaki, M. et al.: Eur. J. Pharm. Mol. Pharm. Sect., 245, 179 (1993); Olessen, O.V., et al.: J. Chromatog., 622, 39 (1993); Pirmohamed, M., et al.: J. Pharmacol. Exp. Ther., 272, 984 (1995)

Fórmula: C₁₇H₁₇ClN₄

Cor e Forma: Light Yellow

Peso molecular: 312.80

Ref: TR-D292000

N-Desmethylclozapine

CAS: 6104-71-8

M01651 - N-Desmethylclozapine

Fórmula: C₁₇H₁₇ClN₄

Pureza: >99%

Cor e Forma: Solid

Peso molecular: 312.8

Ref: 10-M01651

N-Desmethyl clozapine

CAS: 6104-71-8

N-Desmethyl clozapine is a metabolite of the anti-psychotic drug clozapine. It has been shown to have similar effects to clozapine and can be used as an alternative treatment for chronic schizophrenia. The metabolite has been detected in human serum using a chromatographic method, which is an analytical technique that separates molecules based on their size and charge. N-Desmethyl clozapine was found to have a longer half-life than the parent compound, with a detection limit of 1 ng/mL in human serum. This metabolite also has been shown to inhibit fatty acid synthase activity and COX-1 activity in vitro, which may be responsible for its antipsychotic effects.

Fórmula: C₁₇H₁₇ClN₄

Pureza: Min. 95%

Peso molecular: 312.8 g/mol

Ref: 3D-FD21255

N-DESMETHYLCLOZAPINE

CAS: 6104-71-8

Fórmula: C₁₇H₁₇ClN₄

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 312.7967

Ref: IN-DA00EB3S