CAS 6112-76-1

6-Mercaptopurina monohidratada

Descrição:

6-Mercaptopurina monohidratada é um análogo de purina e um antimetabolito usado principalmente no tratamento de certos tipos de leucemia e doenças autoimunes. É caracterizado pela sua fórmula química C5H6N4S·H2O, indicando a presença de um grupo mercapto (-SH) que contribui para sua reatividade e atividade biológica. A substância aparece como um pó cristalino branco a off-white e é solúvel em água, o que facilita sua administração em ambientes clínicos. Seu mecanismo de ação envolve a inibição da síntese de nucleotídeos de purina, interferindo assim na síntese de DNA e RNA, que é crucial para células que se dividem rapidamente. A 6-mercaptopurina é frequentemente administrada em conjunto com outros medicamentos para aumentar a eficácia terapêutica e reduzir o risco de resistência. Devido ao seu potencial de toxicidade, o monitoramento cuidadoso das contagens sanguíneas e da função hepática é essencial durante o tratamento. Além disso, é importante considerar fatores genéticos, como variações na enzima TPMT, que podem afetar as respostas individuais ao medicamento.

Fórmula: C₅H₄N₄S·H₂O

InChI: InChI=1S/C5H4N4S.H2O/c10-5-3-4(7-1-6-3)8-2-9-5;/h1-2H,(H2,6,7,8,9,10);1H2

Chave InChI: InChIKey=WFFQYWAAEWLHJC-UHFFFAOYSA-N

SMILES: S=C1C2=C(NC=N1)N=CN2.O

Sinónimos:

• 1,4,5,7-Tetrahydro-6H-Purine-6-Thione Hydrate
• 1,7-Dihydro-6H-Purin-6-Thion,Monohydrat
• 1,7-Dihydro-6H-Purine-6-Thionemonohydrate
• 1,7-Dihydro-6H-Purine-6-Thionmonohydrate
• 3,7-Dihydro-6H-Purine-6-Thione Hydrate
• 6-Mercapto Purine
• 6-Mercaptopurine Hydrate
• 6-Merkaptopurin,Monohydrat
• 6-Purinethiol Monohydrate
• 6-Thiohypoxanthine Monohydrate
• 6H-Purin-6-Thion,Monohydrat
• 6H-Purine-6-thione, 1,2,3,9-tetrahydro-, hydrate (1:1)
• 6H-Purine-6-thione, 1,7-dihydro-, monohydrate
• 7H-Purine-6-Thiolate
• 9H-Purine-6-thiol hydrate
• Leukerin Monohydrate
• Mercaleukin Monohydrate
• Mercaptopurine Monohydrate, 6-Mercaptopurine
• Mercaptopurine, Monohydrate
• Purin-6-Thiol,Monohydrat
• Purine-6-Thiol, Monohydrate
• Xaluprine
• 6-Mercaptopurine monohydrate

6-Mercaptopurine Monohydrate

CAS: 50-44-2, 6112-76-1

Fórmula: C₅H₄N₄S·H₂O

Pureza: >98.0%(T)(HPLC)

Cor e Forma: Light yellow to Yellow powder to crystal

Peso molecular: 170.20

Ref: 3B-M0063

6-Mercaptopurine monohydrate, 98%

CAS: 6112-76-1

6-Mercaptopurine is a widely used antileukemic agent that inhibits de novopurine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA. It is also an antitumor agent and induces apoptosis. This Thermo Scientific Chemicals brand product was originally part of th

Fórmula: C₅H₆N₄OS

Pureza: 98%

Cor e Forma: Yellow, Powder

Peso molecular: 170.19

Ref: 02-A12197

Mercaptopurine

CAS: 6112-76-1

Mercaptopurine

Fórmula: C₅H₄N₄SH₂O

Pureza: 100.3%

Cor e Forma: Yellow

Peso molecular: 170.02623

Ref: 47-773

MERCAPTOPURINE MONOHYDRATE CRS

CAS: 6112-76-1

MERCAPTOPURINE MONOHYDRATE CRS

Ref: 41-Y0002452

Mercaptopurine impurity standard

CAS: 6112-76-1

Mercaptopurine impurity standard

Cor e Forma: Yellow

Ref: 47-762

Mercaptopurine

CAS: 6112-76-1

Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure

Fórmula: C₅H₄N₄S·H₂O

Cor e Forma: Yellow Crystalline Powder

Peso molecular: 170.19

Ref: 45-1392002

6-Mercaptopurine monohydrate

CAS: 6112-76-1

Fórmula: C₅H₆N₄OS

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 170.1923

Ref: IN-DA003N94

6-Mercaptopurine hydrate

CAS: 6112-76-1

6-Mercaptopurine hydrate

Pureza: ≥95%

Peso molecular: 170.19g/mol

Ref: 54-BUP15972

6-Mercaptopurine monohydrate

CAS: 6112-76-1

Fórmula: C₅H₄N₄SH₂O

Peso molecular: 170.19

Ref: 7W-GE6799

6-Mercaptopurine-13C-15N2 (Azathioprine EP Impurity B-13C-15N2)

CAS: 207729-57-5, 50-44-2, 6112-76-1

Fórmula: C₄₁₃CH₄N₂₁₅N₂S

Peso molecular: 155.15

Ref: 4Z-M-834

Mercaptopurine Monohydrate

CAS: 6112-76-1

Cor e Forma: Neat

Ref: 86-MM1537.00

6-Mercaptopurine monohydrate

CAS: 6112-76-1

Fórmula: C5H4N4S.H2O

Cor e Forma: Light yellow powder

Peso molecular: 170.1923

Ref: 3T-12652909

6-Mercaptopurine monohydrate

CAS: 6112-76-1

6-Mercaptopurine monohydrate

Fórmula: C₅H₄N₄S·H₂O

Pureza: By hplc: 98.7% (Typical Value in Batch COA)

Cor e Forma: yellow powder

Peso molecular: 170.19g/mol

Ref: 54-BIM0129

6-Mercaptopurine hydrate

CAS: 6112-76-1

6-Mercaptopurine hydrate is a leukemia treatment; it blocks purine metabolism, affecting DNA synthesis.

Fórmula: C₅H₆N₄OS

Pureza: 97.54% - 99.14%

Cor e Forma: Light Yellow Crystalline Powder

Peso molecular: 170.19

Ref: TM-T2201

6-Mercaptopurine Monohydrate (Azathioprine EP Impurity B Monohydrate)

CAS: 6112-76-1

Fórmula: C₅H₄N₄S·H₂O

Peso molecular: 152.18 18.02

Ref: 4Z-M-833

6-Mercaptopurine Monohydrate

Produto Controlado

CAS: 6112-76-1

Applications An immunosuppressive drug used to treat leukemia. It is also used for pediatric non-Hodgkin’s lymphoma, polycythemia vera, and psoriatic arthritis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Zeng, H., et al.: Biochem. Pharmacol., 68, 911 (2004),

Fórmula: C₅H₄N₄S·H₂O

Cor e Forma: Yellow

Peso molecular: 170.19

Ref: TR-M225450

6-Mercaptopurine hydrate

CAS: 6112-76-1

6-Mercaptopurine is a purine analog that suppresses the production of white blood cells by inhibiting the enzyme thiopurine methyltransferase. It has been used to treat bowel disease and also for long-term suppression of the immune system in patients with autoimmune diseases. 6-Mercaptopurine is metabolized to 6-mercaptopurine, which is then converted to dinucleotide phosphate (dNTP) by group P2 enzymes. This conversion allows 6-mercaptopurine to inhibit dNTP synthesis and cell division. The effects of 6-mercaptopurine are potentiated when given in conjunction with azathioprine, another drug that inhibits purine metabolism. 6-Mercaptopurine is not active against human serum albumin or erythrocytes because it cannot be cleaved into an active form by these proteins. However, it does inhibit enzyme activities such as DNA polymerase, RNA polymerase, and protein

Fórmula: C₅H₄N₄S•H₂O

Pureza: Min. 97 Area-%

Cor e Forma: Yellow Powder

Peso molecular: 152.18 g/mol

Ref: 3D-FM08197

6-Mercaptopurine Monohydrate extrapure, 99%

CAS: 6112-76-1

Fórmula: C₅H₄N₄S·H₂O

Pureza: min. 99%

Cor e Forma: Yellow, Crystalline powder

Peso molecular: 170.19

Ref: SR-18382

6-Mercaptopurine monohydrate

CAS: 6112-76-1

Fórmula: C₅H₆N₄OS

Pureza: 98.0%

Cor e Forma: Solid

Peso molecular: 170.19

Ref: 10-F358394

Mercaptopurine impurity standard

CAS: 6112-76-1

Mercaptopurine impurity standard is a drug product that is used as an analytical reference standard in the development of drugs. Mercaptopurine impurity standard is a natural metabolite of 6-mercaptopurine, which is used to treat leukemia and other forms of cancer. It has been shown to have an anti-inflammatory effect, but this has not been confirmed. Mercaptopurine impurity standard is a synthetic compound that is made synthetically for use as an impurity standard. It has also been shown to be metabolized by cytochrome P450 enzymes, glutathione reductase, or conjugation with glucuronic acid. Mercaptopurine impurity standard has been shown to be stable under acidic conditions and heat treatment at temperatures up to 200°C.

Pureza: Min. 95%

Ref: 3D-IM63780