CAS 61177-45-5

Clavulanato de potássio

Descrição:

Clavulanato de potássio é um composto beta-lactâmico que atua como um potente inibidor das enzimas beta-lactamases, que são produzidas por certas bactérias para conferir resistência contra antibióticos beta-lactâmicos. É comumente utilizado em combinação com antibióticos penicilínicos, como a amoxicilina, para aumentar sua eficácia contra cepas bacterianas resistentes. A substância aparece como um pó cristalino branco a off-white e é solúvel em água, o que facilita seu uso em formulações farmacêuticas. Seu mecanismo de ação envolve a ligação irreversível ao sítio ativo das beta-lactamases, impedindo assim a hidrólise dos antibióticos beta-lactâmicos e permitindo que exerçam seus efeitos antibacterianos. Clavulanato de potássio geralmente é bem tolerado, embora possa causar efeitos colaterais em alguns indivíduos, incluindo distúrbios gastrointestinais. É importante notar que, embora aumente a eficácia dos antibióticos, não possui atividade antibacteriana significativa por si só. Como agente farmacêutico, é crucial usar Clavulanato de potássio sob supervisão médica para garantir a dosagem adequada e mitigar potenciais efeitos adversos.

Fórmula: C₈H₉NO₅·K

InChI: InChI=1S/C8H9NO5.K/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4;/h1,6-7,10H,2-3H2,(H,12,13);/b4-1-;/t6-,7-;/m1./s1

Chave InChI: InChIKey=FERIANDDKNFRJI-JSYANWSFSA-N

SMILES: C(O)(=O)[C@@H]\1N2[C@](O/C1=C\CO)(CC2=O)[H].[K]

Sinónimos:

• 4-Oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, monopotassium salt, (2R,3Z,5R)-
• 4-Oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, monopotassium salt, [2R-(2α,3Z,5α)]-
• 4-Oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, potassium salt (1:1), (2R,3Z,5R)-
• Brl 14151K
• Clavitesse
• Clavulanic acid potassium salt
• Potassium clavulanate
• Serdaxin
• potassium (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylate

potassium (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylate

CAS: 61177-45-5

Fórmula: C₈H₈KNO₅

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 237.2511

Ref: IN-DA0035ID

Potassium Clavulanate

CAS: 61177-45-5

Fórmula: C₈H₈NO₅·K

Cor e Forma: White To Off-White Solid

Peso molecular: 198.16 39.10

Ref: 4Z-C-328

Potassium clavulanate with microcrystalline cellulose

CAS: 61177-45-5

Fórmula: C₈H₈NO₅K

Pureza: Clavulanic acid: 38.3 - 45.0 %

Cor e Forma: White or almost white powder

Peso molecular: 237.25

Ref: 7W-GA1260

Clavulanate:Cellulose

CAS: 61177-45-5

Clavulanate:Cellulose

Fórmula: C₈H₈NO₅·K

Cor e Forma: white or almost white crystalline powder

Peso molecular: 237.25g/mol

Ref: 54-BIC581

Clavulanic acid potassium

CAS: 61177-45-5

Fórmula: C₈H₈NO₅·K

Cor e Forma: Neat

Peso molecular: 237.25

Ref: 04-C11668545

Clavulanic Acid Potassium Salt

CAS: 61177-45-5

Stability Hygroscopic, Temperature sensitive
Applications Clavulanic Acid is a β-lactamase inhibitor, typically added to amoxicillin to increase its effectiveness.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Reading, C. and Cole, M.: Antimicrob. Ag. Chemother., 11, 852 (1977), Ball, A.P., et al.: Lancet, 1, 620 (1980), Brogden, R.N., et al. Drugs, 22, 337 (1981)

Fórmula: C₈H₈NO₅·K

Cor e Forma: Light Yellow To Dark Brown

Peso molecular: 237.25

Ref: TR-C563750

Potassium clavulanate - 1:1 mixture with silicon dioxide

CAS: 61177-45-5

Potassium clavulanate is a beta-lactamase inhibitor that is used in the treatment of bacterial infections. The active site of potassium clavulanate is the beta-lactam ring, which has an ester bond to the 4-hydroxyl group of the penicillin nucleus. This bond can be hydrolyzed by beta-lactamase, an enzyme produced by bacteria, which will render the antibiotic ineffective. Potassium clavulanate inhibits this enzyme by binding to it and preventing it from breaking down penicillin. The temperature range for potassium clavulanate is between 2°C and 30°C, and its UV spectrophotometric technique ranges from 220 nm to 350 nm.

Fórmula: C₈H₈NO₅·K

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 237.25 g/mol

Ref: 3D-FP30769

Potassium clavulanate - 1:1 mixture with cellulose

CAS: 61177-45-5

Potassium clavulanate is a beta-lactamase inhibitor that is used in the treatment of bacterial infections. The active site of potassium clavulanate is the beta-lactam ring, which has an ester bond to the 4-hydroxyl group of the penicillin nucleus. This bond can be hydrolyzed by beta-lactamase, an enzyme produced by bacteria, which will render the antibiotic ineffective. Potassium clavulanate inhibits this enzyme by binding to it and preventing it from breaking down penicillin. The temperature range for potassium clavulanate is between 2°C and 30°C, and its UV spectrophotometric technique ranges from 220 nm to 350 nm.

Fórmula: C₈H₈NO₅·K

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 237.25 g/mol

Ref: 3D-FP16197

Clavulanate potassium

CAS: 61177-45-5

Clavulanate potassium,β-Lactamase inhibitor with antibiotic activity.

Fórmula: C₈H₈KNO₅

Cor e Forma: Solid

Peso molecular: 237.25

Ref: TM-T67431

Potassium clavulanate (40%) : silicon dioxide mixture

CAS: 61177-45-5

Fórmula: C₈H₈KNO₅

Pureza: 95.0%

Cor e Forma: Solid

Peso molecular: 237.252

Ref: 10-F237796

Clavulanic Acid Potassium Salt in Cellulose (1:1 mixture)

CAS: 61177-45-5

Applications Clavulanic Acid is a β-lactamase inhibitor, typically added to amoxicillin to increase its effectiveness.
References Reading, C. and Cole, M.: Antimicrob. Ag. Chemother., 11, 852 (1977), Ball, A.P., et al.: Lancet, 1, 620 (1980), Brogden, R.N., et al. Drugs, 22, 337 (1981)

Fórmula: C₈H₈NO₅·K

Cor e Forma: Mixture

Peso molecular: 237.25

Ref: TR-C563751

Potassium clavulanate - 1:1 mixture with cellulose, Antibiotic for Culture Media Use Only

CAS: 61177-45-5

Potassium clavulanate is a beta-lactamase inhibitor and an antibacterial agent. The presence of potassium clavulanate in culture media inhibits the activity of beta-lactamases, which are enzymes that confer resistance to penicillin and other beta-lactam antibiotics. It also has been shown to be active against bacterial infections such as tuberculosis, sepsis, and pneumonia, where it can inhibit the growth of bacteria by interfering with their ability to form cell walls.

Fórmula: C₈H₈KNO₅

Pureza: Min. 95.0 Area-%

Peso molecular: 237.25 g/mol

Ref: 3D-W-105420

Potassium clavulanate

CAS: 61177-45-5

Potassium clavulanate is a beta-lactamase inhibitor and an antibacterial agent. The presence of potassium clavulanate in culture media inhibits the activity of beta-lactamases, which are enzymes that confer resistance to penicillin and other beta-lactam antibiotics. It also has been shown to be active against bacterial infections such as tuberculosis, sepsis, and pneumonia, where it can inhibit the growth of bacteria by interfering with their ability to form cell walls. Potassium clavulanate is also used as an antimicrobial agent for blood culture technique and antimicrobial treatment.

Fórmula: C₈H₈NO₅·K

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 237.25 g/mol

Ref: 3D-FP10878