CAS 62996-74-1

Estaurosporina

Descrição:

Estaurosporina é um potente alcaloide derivado da bactéria Streptomyces staurosporeus, conhecido por seus efeitos inibitórios de amplo espectro sobre as quinases. É caracterizado por sua complexa estrutura tetracíclica, que contribui para sua atividade biológica. Estaurosporina exibe uma alta afinidade por várias quinases, incluindo aquelas envolvidas em vias de sinalização celular, tornando-se uma ferramenta valiosa na pesquisa para estudar processos celulares como apoptose e proliferação celular. O composto é tipicamente utilizado em ambientes de laboratório para investigar os mecanismos do câncer e outras doenças. Estaurosporina também é reconhecido por suas potenciais aplicações terapêuticas, embora seu uso seja limitado devido à sua natureza não seletiva e à toxicidade associada. Em termos de propriedades físicas, é um sólido cristalino que é solúvel em solventes orgânicos, mas tem solubilidade limitada em água. Como um produto químico de pesquisa, é importante manusear Estaurosporina com cuidado, aderindo aos protocolos de segurança devido aos seus potentes efeitos biológicos.

Fórmula: C₂₈H₂₆N₄O₃

InChI: InChI=1/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/p+1/t17-,20-,26-,28+/m1/s1

Chave InChI: InChIKey=HKSZLNNOFSGOKW-FYTWVXJKSA-N

SMILES: C[C@]12N3C=4C5=C(C6=C(C4C=7C3=CC=CC7)CNC6=O)C=8C(N5[C@](O1)(C[C@@H](NC)[C@H]2OC)[H])=CC=CC8

Sinónimos:

• (5R,6S,7S)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one
• (5R,6S,7S,9S)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one
• (5S,6R,7R,9R)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one
• (5S,6R,7R,9R)-6-methoxy-N,5-dimethyl-14-oxo-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-7-aminium
• (9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
• 8,12-Epoxy-1H,8H-2,7b,12a-triazadibenzo(a,g)cyclonona(cde)trinden-1-one, 2,3,9,10,11,12-hexahydro-9-methoxy-8-methyl-10-(methylamino)-, (8alpha,9beta,10beta,12alpha)-(+)-
• 9,13-Epoxy-1H,9H-diindolo(1,2,3-gh:3',2',1'-lm)pyrrolo(3,4-j)(1,7)-benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, (9S-(9alpha,10beta,11beta,13alpha)-
• 9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, (9S,10R,11R,13R)-
• 9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, [9S-(9α,10β,11β,13α)]-
• 9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, (9S,10R,11R,13R)-
• 9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, [9S-(9α,10β,11β,13α)]-
• Alkaloid AM-2282 from Streptomyces
• Am-2282
• Antibiotic 230
• Antibiotic AM 2282
• Ccris 3272
• Cgp 39360
• Staurosporin
• (+)-Staurosporine
• Staurosporine
• STAUROSPORINE FROM STREPTOMYCES SP., PGE WITH 250 UG
• [9S,10α,11α,13β,(+)]-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
• (9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
• Staurosporine,AM-2282,STS
• STAUROSPORINE FROM STREPTOMYCES SP MOLECULAR BIOLOGY REAGENT 98+%
• Stauroporine
• [9S-(9A,10B,11B,13A)]-2,3,10,11,12,13-HEXAHYDRO-10-METHOXY-9-METHYL-11-(METHYLAMINO)-9,13-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-1M]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1-ONE
• 2,3,10,11,12,13-HEXAHYDRO-10R-METHOXY-9S-METHYL-11R-METHYLAMINO-9S,13R-EPOXY-1H,9H-DIINDOLO[1,2,3-GH:3',2',1'-LM]PYRROLO[3,4-J][1,7]BENZODIAZONIN-1 ONE
• STAUROSPORINE, STREPTOMYCES STAUROSPOREUS
• STAUROSPORINE, STREPTOMYCES SPECIES
• Staurosporine, Antibiotic AM-2282
• (9S,10α,11α,13β)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
• yT5720idec Monophosphorothioate, Rp-IsoMer, TriethylaMMoniuM SaltuM Saltnoic acid salt
• STAUROSPORINE, 99+%.
• ANTIBIOTIC M 193
• 9,13-Epoxy-1H,9H-diindolo1,2,3-gh:3,2,1-lmpyrrolo3,4-j1,7benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, (9S,10R,11R,13R)-
• STSP
• Staurosporineinsolution
• InSolution Staurosporine, Streptomyces sp
• Staurosporine,98%
• [9S-(9alpha,10beta,11beta,13alpha)]-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-1m]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
• STAUROSPORINE READY-MADE SOLUTION
• STAUROSPORINE FROM STREPTOMYCES SP.
• Staurosporine(CGP 41251)
• [9S-(9α,10β,11β,13α)]-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one

Staurosporine

CAS: 62996-74-1

Fórmula: C₂₈H₂₆N₄O₃

Pureza: >98.0%(HPLC)

Cor e Forma: White to Light yellow powder to crystal

Peso molecular: 466.54

Ref: 3B-T4000

Staurosporine, 99+%

CAS: 62996-74-1

Staurosporine, 62996-74-1, is a cell-permeable bacterial alkyloid and protein kinase inhibitor with anti-cancer properties. Learn more at Thermo Fisher Scientific.

Fórmula: C₂₈H₂₆N₄O₃

Pureza: 99+%

Cor e Forma: Crystalline powder or granular, White to pale cream to yellow

Peso molecular: 466.54

Ref: 02-J62837

Staurosporine

CAS: 62996-74-1

Fórmula: C₂₈H₂₆N₄O₃

Pureza: 100.0%

Cor e Forma: Yellow powder

Peso molecular: 466.0

Ref: 8R-PB0005

Staurosporine

CAS: 62996-74-1

Fórmula: C₂₈H₂₆N₄O₃

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 466.5310

Ref: IN-DA00365L

Staurosporine

CAS: 62996-74-1

Staurosporine

Pureza: ≥98%

Peso molecular: 466.53g/mol

Ref: 54-BUP12221

Staurosporine, from Streptomyces sp.

CAS: 62996-74-1

Staurosporine, from Streptomyces sp.

Fórmula: C₂₈H₂₆N₄O₃

Pureza: 98%

Cor e Forma: off-white powder

Peso molecular: 466.53103g/mol

Ref: 54-BIS0504

Staurosporine

CAS: 62996-74-1

Fórmula: C₂₈H₂₆N₄O₃

Peso molecular: 466.54

Ref: 4Z-S-172001

Staurosporine

CAS: 62996-74-1

Fórmula: C₂₈H₂₆N₄O₃

Cor e Forma: Neat

Peso molecular: 466.53

Ref: 04-C16974200

Staurosporine

CAS: 62996-74-1

Fórmula: C₂₈H₂₆N₄O₃

Pureza: (HPLC) ≥ 98.0%

Cor e Forma: Off-white to yellow solid

Peso molecular: 466.54

Ref: 7W-GA8507

Staurosporine

CAS: 62996-74-1

Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-Fgr

Fórmula: C₂₈H₂₆N₄O₃

Pureza: 99.24% - 99.82%

Cor e Forma: Off-White Powder

Peso molecular: 466.53

Ref: TM-T6680

Staurosporine

Produto Controlado

CAS: 62996-74-1

Inhibitor of protein kinases; induces apoptosis; anti-cancer

Fórmula: C₂₈H₂₆N₄O₃

Pureza: Min. 98 Area-%

Cor e Forma: Off-White Powder

Peso molecular: 466.53 g/mol

Ref: 3D-AS27871

Staurosporine

CAS: 62996-74-1

Pureza: 98%

Peso molecular: 466.2

Ref: 10-F795841

Staurosporin

Produto Controlado

CAS: 62996-74-1

Applications Staurosporine is a protein Kinase C inhibitor that induces apoptosis in many cell types.
References Romanova, D., et al.: Neoplasma, 45, 204 (1998), Condrescu, M., et al.: J. Biol. Chem., 274, 33279 (1999), Chabannes, E., et al.: Cell Signal, 13, 585 (2001),

Fórmula: C₂₈H₂₆N₄O₃

Cor e Forma: Neat

Peso molecular: 466.53

Ref: TR-S685000

Staurosporine

CAS: 62996-74-1

Staurosporine is a fluorogenic substrate for the enzyme staurosporinase that is used in food testing, environmental testing, and diagnostics. It can be conjugated to an antibody or other protein to produce a ligand that binds to a receptor on the cell surface. Staurosporine has been shown to inhibit the activity of various enzymes including phospholipase A2, phospholipase C, and protein kinase C. It also inhibits bacterial DNA gyrase and topoisomerase IV. The fluorescence of staurosporine can be detected with luminometers or fluorescent microscopes.

Fórmula: C₂₈H₂₆N₄O₃

Pureza: Min. 95%

Peso molecular: 466.53 g/mol

Ref: 3D-AS182928

Staurosporine

CAS: 62996-74-1

Fórmula: C₂₈H₂₆N₄O₃

Peso molecular: 466.5

Ref: ST-EA-CP-M107008