CAS 630420-16-5

Asunaprevir

Descrição:

Asunaprevir é um medicamento antiviral usado principalmente no tratamento de infecções pelo vírus da hepatite C (VHC). Funciona como um agente antiviral de ação direta, especificamente um inibidor de protease, que interfere no processo de replicação viral ao inibir a enzima protease NS3/4A, essencial para o ciclo de vida do vírus. A fórmula química de Asunaprevir reflete sua estrutura complexa, que inclui múltiplos grupos funcionais que contribuem para sua atividade farmacológica. Geralmente é administrado em combinação com outros agentes antivirais para aumentar a eficácia e reduzir o risco de resistência. Asunaprevir é caracterizado por sua solubilidade moderada em solventes orgânicos e solubilidade relativamente baixa em água, o que pode influenciar sua biodisponibilidade. A substância é geralmente bem tolerada, embora possa ter efeitos colaterais, incluindo fadiga e distúrbios gastrointestinais. Seu desenvolvimento representa um avanço significativo no tratamento da hepatite C, particularmente para pacientes com genótipos específicos do vírus. O mecanismo de ação de Asunaprevir e seu papel na terapia combinada destacam a importância de estratégias antivirais direcionadas no manejo de infecções virais.

Fórmula: C₃₅H₄₆ClN₅O₉S

InChI: InChI=1S/C35H46ClN5O9S/c1-9-19-16-35(19,31(44)40-51(46,47)22-11-12-22)39-28(42)25-15-21(49-29-24-14-20(36)10-13-23(24)26(48-8)17-37-29)18-41(25)30(43)27(33(2,3)4)38-32(45)50-34(5,6)7/h9-10,13-14,17,19,21-22,25,27H,1,11-12,15-16,18H2,2-8H3,(H,38,45)(H,39,42)(H,40,44)/t19-,21-,25+,27-,35-/m1/s1

Chave InChI: InChIKey=XRWSZZJLZRKHHD-WVWIJVSJSA-N

SMILES: N(C(=O)[C@H]1N(C([C@@H](NC(OC(C)(C)C)=O)[C@](C)(C)C)=O)C[C@H](OC=2C3=C(C(OC)=CN2)C=CC(Cl)=C3)C1)[C@@]4(C(NS(=O)(=O)C5CC5)=O)[C@H](C=C)C4

Sinónimos:

• (1R,2S)-N-[(1,1-Dimethylethoxy)carbonyl]-3-methyl-<span class="text-smallcaps">L</smallcap>-valyl-(4R)-4-[(7-chloro-4-methoxy-1-isoquinolinyl)oxy]-<smallcap>L</span>-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethenylcyclopropanecarboxamide
• 1,1-dimethylethyl [(1S)-1-{[(2S,4R)-4-(7-chloro-4methoxyisoquinolin-1-yloxy)-2-({(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-ethenylcyclopropyl}carbamoyl)pyrrolidin-1-yl]carbonyl}-2,2-dimethylpropyl]carbamate
• 1-[[N-tert-Butoxycarbonyl-<span class="text-smallcaps">L</smallcap>-tert-leucyl-trans-4-[(7-chloro-4-methoxyisoquinolin-1-yl)oxy]-<smallcap>L</span>-prolyl]amino]-N-(cyclopropylsulfonyl)-(1R,2S)-2-vinylcyclopropane-1-carboxamide
• 3-Methyl-N-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-valyl-(4R)-4-[(7-chloro-4-methoxy-1-isoquinolinyl)oxy]-N-{(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-vinylcyclopropyl}-L-prolinamide
• Bms 650032
• Cyclopropanecarboxamide, N-[(1,1-dimethylethoxy)carbonyl]-3-methyl-<span class="text-smallcaps">L</smallcap>-valyl-(4R)-4-[(7-chloro-4-methoxy-1-isoquinolinyl)oxy]-<smallcap>L</span>-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethenyl-, (1R,2S)-
• Cyclopropanecarboxamide, N-[(1,1-dimethylethoxy)carbonyl]-3-methyl-L-valyl-(4R)-4-[(7-chloro-4-methoxy-1-isoquinolinyl)oxy]-L-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethenyl-, (1R,2S)-
• L-Prolinamide, N-[(1,1-dimethylethoxy)carbonyl]-3-methyl-L-valyl-4-[(7-chloro-4-methoxy-1-isoquinolinyl)oxy]-N-[(1R,2S)-1-[[(cyclopropylsulfonyl)amino]carbonyl]-2-ethenylcyclopropyl]-, (4R)-
• Sunvepra
• (1R,2S)-N-[(1,1-Dimethylethoxy)carbonyl]-3-methyl-L-valyl-(4R)-4-[(7-chloro-4-methoxy-1-isoquinolinyl)oxy]-L-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethenylcyclopropanecarboxamide
• Asunaprevir (BMS-650032)
• Asunaprevir

(1R,2S)-N-[(1,1-Dimethylethoxy)carbonyl]-3-methyl-L-valyl-(4R)-4-[(7-chloro-4-methoxy-1-isoquinolinyl)oxy]-L-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethenylcyclopropanecarboxamide

CAS: 630420-16-5

Fórmula: C₃₅H₄₆ClN₅O₉S

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 748.2858

Ref: IN-DA0039UQ

Asunaprevir

CAS: 630420-16-5

Asunaprevir

Pureza: ≥98%

Peso molecular: 748.29g/mol

Ref: 54-BUP09612

Asunaprevir

CAS: 630420-16-5

Asunaprevir (BMS-650032) is an effective hepatitis C virus (HCV) NS3 protease inhibitor.

Fórmula: C₃₅H₄₆ClN₅O₉S

Pureza: 99.34% - 99.8%

Cor e Forma: Solid

Peso molecular: 748.29

Ref: TM-T4474

Asunaprevir

CAS: 630420-16-5

A competitive inhibitor of HCV NS3/4A protease that blocks viral replication. Efficacious in treating HCV-infected patients in combination with daclatasvir. Asunaprevir-resistant replicons are sensitive to NS5A replication complex inhibitor, suggesting potential combination therapy.

Fórmula: C₃₅H₄₆ClN₅O₉S

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 748.29 g/mol

Ref: 3D-FA64945

Asunaprevir

Produto Controlado

CAS: 630420-16-5

Applications Asunaprevir is an inhibitor of the viral enzyme serine protease HCV NS3. Also functions as a second generation NS3/4A protease inhibitor used in the treatment of hepatitis C.
References Takehara, T., et al.: Igaku no Ayumi, 255, 1155 92015); Kalaghatgi, P., et al.: PLoS One, 11, 5 (2016)

Fórmula: C₃₅H₄₆ClN₅O₉S

Cor e Forma: Neat

Peso molecular: 748.29

Ref: TR-A788753