CAS 64-73-3

Cloridrato de demeclociclina

Descrição:

Cloridrato de demeclociclina é um antibiótico de amplo espectro que pertence à classe das tetraciclinas, utilizado principalmente para tratar várias infecções bacterianas. É caracterizado pela sua capacidade de inibir a síntese de proteínas nas bactérias, ligando-se à subunidade ribossomal 30S, impedindo assim o crescimento e a reprodução dos microrganismos. Este composto é tipicamente administrado por via oral e é conhecido por sua eficácia contra uma variedade de bactérias gram-positivas e gram-negativas. Cloridrato de demeclociclina também é utilizado no tratamento de condições como acne e certos tipos de infecções causadas por bactérias resistentes. Além de suas propriedades antibacterianas, tem sido usado no manejo de condições como a secreção inadequada do hormônio antidiurético (SIADH) devido à sua capacidade de induzir diabetes insípido nefrogênico. A substância é geralmente bem tolerada, mas pode causar efeitos colaterais como distúrbios gastrointestinais e fotossensibilidade. Assim como outras tetraciclinas, é contraindicada em crianças e mulheres grávidas devido aos possíveis efeitos no desenvolvimento de ossos e dentes.

Fórmula: C₂₁H₂₁ClN₂O₈·ClH

InChI: InChI=1S/C21H21ClN2O8.ClH/c1-24(2)14-7-5-6-10(16(27)12-9(25)4-3-8(22)11(12)15(6)26)18(29)21(7,32)19(30)13(17(14)28)20(23)31;/h3-4,6-7,14-15,25-26,28-29,32H,5H2,1-2H3,(H2,23,31);1H/t6-,7-,14-,15-,21-;/m0./s1

Chave InChI: InChIKey=GVSJQNRGSCOSNJ-KBHRXELFSA-N

SMILES: O[C@]12[C@]([C@H](N(C)C)C(O)=C(C(N)=O)C1=O)(C[C@]3(C(=C2O)C(=O)C=4C([C@H]3O)=C(Cl)C=CC4O)[H])[H].Cl

Sinónimos:

• 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-, hydrochloride (1:1), (4S,4aS,5aS,6S,12aS)-
• 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-, monohydrochloride
• 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-, monohydrochloride, (4S,4aS,5aS,6S,12aS)-
• 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-, monohydrochloride, [4S-(4α,4aα,5aα,6β,12aα)]-
• 6,10,12,12A-Pentahydroxy-1,11-Dioxo-Ydro-Monohydrochloride
• 6-Demethyl-7-chlorotetracycline hydrochloride
• 7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride
• 7-Chloro-4-Dimethylamino-3,6,10,12,12A-Pentahydroxy-1,11-Dioxo-1,4,4A,5,5A,6,11,12A-Octahydro-Naphthacene-2-Carboxamide Hydrochloride
• 7-Chloro-6-Demethyltetracycline Hydrochloride
• Clortetrin
• Declomycin
• Declomycin hydrochloride
• Declomycinhydrochloride
• Demeclocycline
• Demethylchlorotetracycline hydrochloride
• Demethylchlorotetracyclinehydrochloride
• Demethylchlortetracyclinehydrochloride
• Demetraciclina
• Detravis
• Ledermycin hydrochloride

Demeclocycline hydrochloride

CAS: 64-73-3

Demeclocycline hydrochloride is used as an antibiotic related to tetracycline and produced by streptomyces aureofaciens, and used to maintain effective blood levels for longer periods of time, used as a fluorescent bone-labeling agent in bone histomorphometry. This Thermo Scientific Chemicals brand

Fórmula: C₂₁H₂₁ClN₂O₈•HCl

Peso molecular: 501.32

Ref: 02-J63102

Demeclocycline Hydrochloride

CAS: 64-73-3

Cor e Forma: Neat

Ref: 61-FOR0636.00

DEMECLOCYCLINE FOR SYSTEM SUITABILITY CRS

CAS: 64-73-3

DEMECLOCYCLINE FOR SYSTEM SUITABILITY CRS

Fórmula: C₂₁H₂₂Cl₂N₂O₈

Cor e Forma: Yellow. Powder.

Peso molecular: 501.314

Ref: 41-Y0001707

DEMECLOCYCLINE HYDROCHLORIDE CRS

CAS: 64-73-3

DEMECLOCYCLINE HYDROCHLORIDE CRS

Fórmula: C₂₁H₂₂Cl₂N₂O₈

Cor e Forma: Yellow. Powder.

Peso molecular: 501.314

Ref: 41-D0300000

Demeclocycline hydrochloride

CAS: 64-73-3

Demeclocycline hydrochloride

Fórmula: C₂₁H₂₁ClN₂O₈HCl

Pureza: 90.2%

Cor e Forma: Yellow

Peso molecular: 500.07532

Ref: 47-789

Demeclocycline Hydrochloride

CAS: 64-73-3

Tetracyclines and their derivatives; salts thereof

Fórmula: C₂₁H₂₁ClN₂O₈·HCI

Cor e Forma: Yellow Crystalline Powder

Peso molecular: 604.01094

Ref: 45-1170000

7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride

CAS: 64-73-3

Fórmula: C₂₁H₂₂Cl₂N₂O₈

Pureza: 90%

Cor e Forma: Solid

Peso molecular: 501.3140

Ref: IN-DA0039UL

Demeclocycline hydrochloride

CAS: 64-73-3

Demeclocycline HCl (Declomycin), a tetracycline with 7-Cl & 6-CH₃, has prolonged blood levels due to slower excretion.

Fórmula: C₂₁H₂₁ClN₂O₈·HCl

Pureza: 99.14% - 99.97%

Cor e Forma: Yellow Crystalline Powder Solid

Peso molecular: 501.32

Ref: TM-T1400

Demeclocycline HCl

CAS: 64-73-3

Fórmula: C₂₁H₂₁ClN₂O₈·HCl

Cor e Forma: Yellow Solid

Peso molecular: 464.86 36.46

Ref: 4Z-D-721

(4S,4As,5As,6S,12As)-7-Chloro-4-(Dimethylamino)-3,6,10,12,12a-Pentahydroxy-1,11-Dioxo-1,4,4A,5,5A,6,11,12A-Octahydrotetracene-2-Carboxamide Hydrochloride

CAS: 64-73-3

(4S,4As,5As,6S,12As)-7-Chloro-4-(Dimethylamino)-3,6,10,12,12a-Pentahydroxy-1,11-Dioxo-1,4,4A,5,5A,6,11,12A-Octahydrotetracene-2-Carboxamide Hydrochloride

Pureza: 90%

Peso molecular: 501.31g/mol

Ref: 54-OR1030500

Demeclocycline hydrochloride

CAS: 64-73-3

Fórmula: C₂₁H₂₁ClN₂O₈·HCl

Pureza: 90.0 - 102.0 % (dried basis)

Cor e Forma: Yellow powder

Peso molecular: 501.32

Ref: 7W-GA7186

Demeclocycline hydrochloride

CAS: 64-73-3

Demeclocycline hydrochloride

Pureza: ≥95%

Peso molecular: 501.32g/mol

Ref: 54-BUP17020

PharmaVetResiMix 5 Tetracyclines-v10 10 µg/mL in Methanol

Produto Controlado

CAS: 101342-45-4, 14206-58-7, 179471-95-5, 2058-46-0, 23313-80-6, 24390-14-5, 41411-66-9, 64-72-2, 64-73-3, 64-75-5

Cor e Forma: Mixture

Ref: 04-A30000035ME

Demeclocycline Hydrochloride

Produto Controlado

CAS: 64-73-3

Fórmula: C₂₁H₂₁ClN₂O₈·ClH

Cor e Forma: Neat

Peso molecular: 501.31

Ref: 86-MM0636.00

Demeclocycline hydrochloride

Produto Controlado

CAS: 64-73-3

Fórmula: C₂₁H₂₁ClN₂O₈·ClH

Cor e Forma: Neat

Peso molecular: 501.31

Ref: 04-C12128000

Demeclocycline Hydrochloride

CAS: 64-73-3

Applications An antibiotic related to tetracycline and produced by streptomyces aureofaciens. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.This compound is a contaminant of emerging concern (CECs).
References Jilka, R., et al.: J. Clin. Invest., 104, 439 (1999), Hauge, E; Bone, 28, 556 (2001), Dobnig, H., et al.: J. Clin. Endocrinol. Metab., 90, 3970 (2005),

Fórmula: C₂₁H₂₁ClN₂O₈·ClH

Cor e Forma: Light Yellow To Yellow

Peso molecular: 501.31

Ref: TR-D230725

Demeclocycline hydrochloride

CAS: 64-73-3

Demeclocycline hydrochloride is a tetracycline antibiotic that binds to the tetracycline receptor and inhibits bacterial protein synthesis. Demeclocycline hydrochloride has been shown to be effective against many types of bacteria, including those that are resistant to other antibiotics such as methicillin or vancomycin. Demeclocycline hydrochloride has been used in the treatment of skin cancer and also has anti-inflammatory properties. Demeclocycline hydrochloride is a hydrophobic molecule with a metal chelating ability that can be used for wastewater treatment.

Fórmula: C₂₁H₂₁ClN₂O₈·ClH

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 501.31 g/mol

Ref: 3D-FD20979

Demeclocycline hydrochloride

CAS: 64-73-3

Pureza: 90%

Peso molecular: 501.3099976

Ref: 10-F869293