CAS 65-49-6

Ácido 4-aminossalicílico

Descrição:

Ácido 4-aminossalicílico, também conhecido como ácido para-aminossalicílico (PAS), é um composto aromático com a fórmula molecular C7H9NO3. Apresenta tanto um grupo amino (-NH2) quanto um grupo ácido carboxílico (-COOH) ligados a uma estrutura de ácido salicílico, tornando-se um membro da família dos salicilatos. Este composto aparece como um pó cristalino branco a off-white e é solúvel em água, o que melhora sua biodisponibilidade. Ácido 4-aminossalicílico é conhecido principalmente por seu uso como agente antituberculoso, particularmente no tratamento da tuberculose, especialmente em casos resistentes a outros medicamentos. Seu mecanismo de ação envolve a inibição da síntese de ácido fólico em bactérias, impedindo assim seu crescimento. Além disso, foi estudado por suas potenciais propriedades antioxidantes. Embora geralmente seja bem tolerado, pode causar efeitos colaterais, como distúrbios gastrointestinais e reações de hipersensibilidade. Assim como qualquer composto farmacêutico, o manuseio e a dosagem adequados são cruciais para garantir a segurança e a eficácia nas aplicações terapêuticas.

Fórmula: C₇H₇NO₃

InChI: InChI=1/C7H7NO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,8H2,(H,10,11)

Chave InChI: InChIKey=WUBBRNOQWQTFEX-UHFFFAOYSA-N

SMILES: C(O)(=O)C1=C(O)C=C(N)C=C1

Sinónimos:

• 2-Hydroxy-4-aminobenzoic acid
• 3-Hydroxy-4-carboxyaniline
• 4-Amino-2-hydroxybenzoic acid
• 4-Aminosalicylsaure
• 4-Asa
• 4-Carboxy-3-hydroxyaniline
• Acide 4-aminosalicylique
• Acido 4-Aminosalicilico
• Amino-PAS
• Aminosalicylic Acid
• Apacil
• Apas
• Benzoic acid, 4-amino-2-hydroxy-
• Deapasil
• Entepas
• Euteropas
• Gabbropas
• Granupas
• Monopass
• Nsc 2083
• Nsc 211698
• Osacyl
• PAS
• PAS (acid)
• Pamacyl
• Pamisyl
• Para-Pas
• Para-aminosalicylic acid
• Paramycin
• Parasal
• Parasalicil
• Parasalindon
• Pasa
• Pasalon
• Pasara
• Pasem
• Paser
• Pask
• Pasmed
• Pasnodia
• Pasolac
• Propasa
• Rezipas
• Salicylic acid, 4-amino-
• Sanipirol-4
• p-Aminosalicylic acid
• SCHIFF REAGENT
• SCHIFF REAGENT, HOTCHKISS/MCMANUS
• SCHIFF'S REAGENT FOR ALDEHYDES
• SCHIFFS REAGENT
• SCHIFF'S REAGENT
• PERIODIC ACID-SCHIFF
• FUCHSIN SULFUROUS ACID
• 4-amino-2-hydroxy-benzoicaci
• SCHIFF REAGENT SOLUTION, MODIFIED
• 4-Amino-2-hydroxbenzoicacid
• 4-Aminosalicyclic acid
• 4-AMINOSALICYLIC ACID
• SCHIFF'S FUCHSIN-SULFITE REAGENT

4-Aminosalicylic acid, 98+%

CAS: 65-49-6

Competitive pteridine synthetase inhibitor, has antibacterial capable of inhibiting the growth of Mycobacterium tuberculosis. It inhibits NF-B and folic acid synthesis. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and labe

Fórmula: C₇H₇NO₃

Pureza: 98+%

Cor e Forma: White to pale brown or pale grey, Powder

Peso molecular: 153.14

Ref: 02-B23289

Aminosalicylic Acid

CAS: 65-49-6

Aromatic amino-alcohol-phenols, aromatic amino-acid-phenols and other aromatic amino compounds with oxygen function

Fórmula: C₇H₇NO₃

Cor e Forma: White Beige Powder

Peso molecular: 153.04259

Ref: 45-1026401

4-Amino-2-hydroxybenzoic acid

CAS: 65-49-6

Fórmula: C₇H₇NO₃

Pureza: 96%

Cor e Forma: Solid

Peso molecular: 153.1354

Ref: IN-DA003KS5

4-Aminosalicylic acid

CAS: 65-49-6

4-Aminosalicylic acid (para-aminosalicylic acid) is an analog of para-aminobenzoic acid (PABA) with antitubercular activity.

Fórmula: C₇H₇NO₃

Pureza: 97.03% - 98.39%

Cor e Forma: Minute Crystals From Alc Solid

Peso molecular: 153.14

Ref: TM-T1296

4-Aminosalicylic acid

CAS: 65-49-6

4-Aminosalicylic acid

Pureza: ≥95%

Peso molecular: 153.14g/mol

Ref: 54-BUP19585

4-Aminosalicylic acid

CAS: 65-49-6

Fórmula: C₇H₇NO₃

Pureza: (Titration) 98.5 - 101.5 %

Cor e Forma: White to pale yellow or pale brown

Peso molecular: 153.14

Ref: 7W-GM8827

Mesalazine (Mesalamine) EP Impurity E

CAS: 65-49-6

Fórmula: C₇H₇NO₃

Cor e Forma: Brown Solid

Peso molecular: 153.14

Ref: 4Z-M-1740

4-Amino-2-hydroxybenzoic acid

CAS: 65-49-6

4-Amino-2-hydroxybenzoic acid

Fórmula: C₇H₇NO₃

Pureza: 99%

Cor e Forma: nearly white powder

Peso molecular: 153.13538g/mol

Ref: 54-OR22063

4-Aminosalicylic acid

CAS: 65-49-6

Fórmula: C₇H₇NO₃

Cor e Forma: Neat

Peso molecular: 153.14

Ref: 04-C10227010

4-Aminosalicylic acid (Standard)

CAS: 65-49-6

4-Aminosalicylic acid (Standard) is the standard substance of 4-Aminosalicylic acid, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. 4-Aminosalicylic acid (para-aminosalicylic acid) is an analog of para-aminobenzoic acid (PABA) with antitubercular activity.

Fórmula: C₇H₇NO₃

Peso molecular: 153.14

Ref: TM-TMSM-0270

4-Aminosalicylic Acid

CAS: 65-49-6

Fórmula: C₇H₇NO₃

Pureza: >98.0%(T)

Cor e Forma: White to Light gray to Light orange powder to crystal

Peso molecular: 153.14

Ref: 3B-A0420

4-Aminosalicylic Acid

CAS: 65-49-6

Impurity Mesalazine EP Impurity E
Stability Hygroscopic
Applications 4-Aminosalicylic Acid is an antibiotic used to treat tuberculosis.
References Horita, Y., et al.: Bioorg. Med. Chem. Lett., 19, 6313 (2009); Martins, M., et al.: J. Biol. Chem., 284, 18726 (2009); Fourches, D., et al.: Chem. Res. Toxicol., 23, 171 (2010);

Fórmula: C₇H₇NO₃

Cor e Forma: Beige

Peso molecular: 153.14

Ref: TR-A629220

Mesalazine EP Impurity E

CAS: 65-49-6

Fórmula: C₇H₇O₃N

Peso molecular: 153.14

Ref: ST-EA-CP-M11005

4-Aminosalicylic acid

CAS: 65-49-6

4-Aminosalicylic acid (4-ASA) is a drug with anti-inflammatory and analgesic properties. It is used in the treatment of bowel disease, including ulcerative colitis and Crohn's disease. 4-ASA binds to the 4th carbon on the para position of p-hydroxybenzoic acid, which is a metabolite of salicylic acid. This binding inhibits the activity of proton pumps that are responsible for maintaining intracellular pH levels in cells. It also prevents the production of inflammatory prostaglandins by inhibiting cyclooxygenase 1 and 2, which are enzymes that catalyze the conversion of arachidonic acid to prostaglandin H2. 4-ASA also has an effect on bacterial infections by interfering with hydrogen bonding interactions between bacterial dna gyrase and dna topoisomerase II, preventing DNA replication. The x-ray crystal structures have demonstrated that 4-ASA

Fórmula: C₇H₇NO₃

Pureza: Min. 95%

Cor e Forma: Off-White Powder

Peso molecular: 153.14 g/mol

Ref: 3D-FA10792

4-Amino-2-hydroxybenzoic acid

CAS: 65-49-6

Fórmula: C₇H₇NO₃

Pureza: 95%

Cor e Forma: Powder

Peso molecular: 153.137

Ref: 10-F078671