CAS 65147-06-0

Boc-Ile-Glu-Gly-Arg-AMC

Descrição:

Boc-Ile-Glu-Gly-Arg-AMC é um substrato de peptídeo sintético comumente utilizado em pesquisas bioquímicas, particularmente em estudos envolvendo enzimas proteolíticas. O nome indica que é um derivado dos aminoácidos isoleucina (Ile), ácido glutâmico (Glu), glicina (Gly) e arginina (Arg), com um grupo protetor Boc (tert-butiloxicarbonila) no resíduo de isoleucina. O grupo AMC (7-amino-4-metilcumarina) serve como um repórter fluorescente, permitindo o monitoramento da atividade enzimática por meio de ensaios de fluorescência. Este composto é tipicamente utilizado em ensaios para estudar proteases, uma vez que a clivagem da ligação peptídica pela enzima libera o grupo AMC, resultando em um aumento na fluorescência que pode ser medida quantitativamente. A estabilidade do grupo Boc sob certas condições o torna adequado para vários arranjos experimentais. No geral, Boc-Ile-Glu-Gly-Arg-AMC é uma ferramenta valiosa no campo da enzimiologia e da química de peptídeos, auxiliando na compreensão da cinética enzimática e da especificidade do substrato.

Fórmula: C₃₄H₅₀N₈O₁₀

InChI: InChI=1/C34H50N8O10/c1-7-18(2)28(42-33(50)52-34(4,5)6)31(49)40-23(12-13-26(44)45)29(47)38-17-25(43)41-30(48)22(9-8-14-37-32(35)36)39-20-10-11-21-19(3)15-27(46)51-24(21)16-20/h10-11,15-16,18,22-23,28,39H,7-9,12-14,17H2,1-6H3,(H,38,47)(H,40,49)(H,42,50)(H,44,45)(H4,35,36,37)(H,41,43,48)/t18-,22-,23-,28-/m0/s1

SMILES: CC[C@H](C)[C@@H](C(=N[C@@H](CCC(=O)O)C(=NCC(=NC(=O)[C@H](CCCNC(=N)N)Nc1ccc2c(C)cc(=O)oc2c1)O)O)O)N=C(O)OC(C)(C)C

Sinónimos:

• tertiary-Butyloxycarbonyl-isoleucyl-glutamyl-glycyl-arginyl-7-amino-4-methylcoumarin
• Biggam
• Boc-ile-glu-gly-arg-mca
• L-Argininamide, N-((1,1-dimethylethoxy)carbonyl)-L-isoleucyl-L-alpha-glutamylglycyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
• N-(tert-butoxycarbonyl)-L-isoleucyl-L-alpha-glutamyl-N-{(2S)-5-[(diaminomethylidene)amino]-2-[(4-methyl-2-oxo-2H-chromen-7-yl)amino]pentanoyl}glycinamide
• Boc-Ile-Glu-Gly-Arg-Amc Acetate Salt

Boc-Ile-Glu-Gly-Arg-AMC

CAS: 65147-06-0

Boc-IEGR-AMC, a specific, highly fluorogenic substrate for clotting enzyme factor Xa (coagulation factor Xa). Boc-IEGR-AMC is also hydrolyzed by acrosin from the ascidian Halocynthia roretzi. The use of this substrate in the indirect determination of coagulation factor IX has been described.

Fórmula: C₃₄H₅₀N₈O₁₀

Pureza: 97.8%

Cor e Forma: White Powder

Peso molecular: 730.82

Ref: 01-4004961

Boc-Ile-Glu-Gly-Arg-AMC

CAS: 65147-06-0

Boc-IEGR-AMC: fluorogenic substrate for factor Xa and Halocynthia roretzi acrosin.

Fórmula: C₃₄H₅₀N₈O₁₀

Pureza: 98%

Cor e Forma: White Powder

Peso molecular: 730.81

Ref: TM-TP1129

Boc-Ile-Glu-Gly-Arg-AMC

CAS: 65147-06-0

Boc-Ile-Glu-Gly-Arg-AMC is a cell permeable inhibitor of protein interactions that binds to the peptide sequences of the extracellular domain of the epidermal growth factor receptor (EGFR). Boc-Ile-Glu-Gly-Arg-AMC can be used as a research tool to study protein interactions, as well as an inhibitor for EGFR. It is soluble in DMSO and water. This product has been shown to inhibit the activity of ion channels such as voltage dependent calcium channels, potassium channels, and sodium channels. Boc-Ile-Glu-Gly-Arg-AMC also inhibits antibody binding to its antigen.

Fórmula: C₃₄H₅₀N₈O₁₀

Pureza: Min. 95%

Peso molecular: 730.81 g/mol

Ref: 3D-MIE-3094-V

Boc-Ile-Glu-Gly-Arg-AMC acetate salt

CAS: 65147-06-0

Boc-Ile-Glu-Gly-Arg-AMC acetate salt is a homologous peptide derived from soybean trypsin inhibitor. It has a molecular weight of 7,000 daltons and inhibits the activity of serine proteases, including kallikrein, plasmin, and thrombin. This peptide has been shown to be an inhibitor of heparin coagulation factor Xa and tissue factor in vitro. Boc-Ile-Glu-Gly-Arg-AMC acetate salt also has anticoagulant properties in vivo which are due to its ability to inhibit the synthesis of prothrombin.

Fórmula: C₃₄H₅₀N₈O₁₀·C₂H₄O₂

Pureza: Min. 95%

Cor e Forma: Solid

Peso molecular: 790.86 g/mol

Ref: 3D-FB110485