CAS 6543-77-7

4-Epidoxiciclina

Descrição:

4-Epidoxiciclina é um derivado semissintético do antibiótico tetraciclina, projetado especificamente para melhorar suas propriedades antibacterianas. É caracterizado por sua atividade de amplo espectro contra uma variedade de bactérias Gram-positivas e Gram-negativas, tornando-o eficaz no tratamento de várias infecções. O composto apresenta uma estrutura tetracíclica complexa, que é essencial para seu mecanismo de ação, envolvendo principalmente a inibição da síntese de proteínas bacterianas ao se ligar à subunidade 30S do ribossomo. 4-Epidoxiciclina é conhecido por sua estabilidade em ambientes ácidos, o que pode melhorar sua biodisponibilidade. Além disso, exibe um perfil de toxicidade relativamente baixo, tornando-o adequado para uso terapêutico. No entanto, como outras tetraciclinas, pode causar efeitos colaterais, como distúrbios gastrointestinais e fotossensibilidade. Seu uso também é limitado pelo potencial de desenvolvimento de resistência a antibióticos. No geral, 4-Epidoxiciclina representa um composto importante no campo da terapia antimicrobiana, contribuindo para os esforços contínuos para combater infecções bacterianas.

Fórmula: C₂₂H₂₄N₂O₈

InChI: InChI=1/C22H24N2O8/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29/h4-7,10,14-15,17,25-27,31-32H,23H2,1-3H3/b21-13-/t7-,10+,14+,15+,17-,22-/m0/s1

Chave InChI: InChIKey=JBIWCJUYHHGXTC-NLJUDYQYSA-N

SMILES: O[C@]12[C@]([C@@H](N(C)C)C(O)=C(C(N)=O)C1=O)([C@@H](O)[C@]3(C(=C2O)C(=O)C=4C([C@@H]3C)=CC=CC4O)[H])[H]

Sinónimos:

• 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, 4-epimer
• 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4R,4aR,5S,5aR,6R,12aS)-
• (4R,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide
• 4-Epioxytetracycline, 6-deoxy-
• 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, [4R-(4α,4aβ,5β,5aβ,6β,12aβ)]-
• Doxycycline Impurity 3(Doxycycline EP Impurity C)(4-epi-Doxycycline)
• 4-EPI DOXYCYCLINE DXC03-100
• DOCYCYCLINE
• 4-Epi Doxycycline (>70%)
• Doxycycline hyclate EP Impurity C
• 4-Epi Doxycycline (Crude)
• 4-Epi Doxycycline Hydrochloride Q: What is the CAS Number of
• 4-Epi Doxycycline Hydrochloride
• 4-Epi Doxycycline Hydrochloride Q: What is the storage condition of
• 4-Epi Doxycycline Hydrochloride Q: What are the applications of
• (4S,5S,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a
• 4-Epi DoxycycL
• 6-Deoxy-4-epioxytetracycline USP/EP/BP
• 4-Epi Doxycycline
• Doxycycline Impurity 7
• Doxycycline Impurity 3（Doxycycline EP Impurity C）
• 4-Epi Doxycycline HydrochlorideQ: What is
• 6-Deoxy-4-epioxytetracycline
• Doxycycline EP Impurity C / 4-Epidoxycycline / Doxycycline Related Compound C
• Doxycycline EP Impurity C/4-Epi Doxycycline

Doxycycline EP Impurity C (4-epi Doxycycline)

CAS: 6543-77-7

Fórmula: C₂₂H₂₄N₂O₈

Peso molecular: 444.44

Ref: 4Z-D-185

4-Epidoxycycline

CAS: 6543-77-7

4-Epidoxycycline is a hepatic metabolite of the antibiotic doxycycline and lacks antibiotic properties in mice. In both in vitro assays and in vivo mouse models, 4-Epidoxycycline regulates HER2 gene expression similarly to doxycycline and exhibits comparable efficacy in tumor tissues, achieving over 95% tumor regression rates.

Fórmula: C₂₂H₂₄N₂O₈

Cor e Forma: Solid

Peso molecular: 444.44

Ref: TM-T203210

Doxycycline EP Impurity C

CAS: 6543-77-7

Fórmula: C₂₂H₂₄N₂O₈

Peso molecular: 444.44

Ref: ST-EA-CP-D56003

4-Epi Doxycycline (>70%)

Produto Controlado

CAS: 6543-77-7

Impurity Doxycycline EP Impurity C
Stability Light Sensitive, Unstable in Solution
Applications An alternative to doxycycline to control gene expression.
References Schiffer, I., et al.: Cancer Res. 63, 7221 (2003) , Eger, K. , et al.: Biochem. Biophys. Res. Comm., 323, 979, (2004).

Fórmula: C₂₂H₂₄N₂O₈

Pureza: >70%

Cor e Forma: Yellow Solid

Peso molecular: 444.43

Ref: TR-E585900

4-Epidoxycycline

CAS: 6543-77-7

4-Epidoxycycline is a tetracycline antibiotic that inhibits the growth of bacteria by binding to bacterial ribosomes and blocking protein synthesis. This drug also has anti-inflammatory properties and can be used to treat bowel disease. 4-Epidoxycycline has been found to be effective in vivo models for experimental models of inflammatory lesions, such as ulcerative colitis, ileitis, or Crohn's disease. This antibiotic has not been shown to have any toxic effects on the heart or blood pressure.

Fórmula: C₂₂H₂₄N₂O₈

Pureza: 95%Min

Cor e Forma: Powder

Peso molecular: 444.43 g/mol

Ref: 3D-FE32560