CAS 654671-77-9
:Fosfato de sitagliptina monohidratado
Descrição:
Fosfato de sitagliptina monohidratado é um composto farmacêutico utilizado principalmente no manejo do diabetes mellitus tipo 2. Funciona como um inibidor da dipeptidil peptidase-4 (DPP-4), que aumenta os níveis de incretina no corpo, levando a um aumento na secreção de insulina e a uma diminuição nos níveis de glucagon em resposta às refeições. Esse mecanismo ajuda a reduzir os níveis de glicose no sangue. A substância aparece como um pó cristalino branco a off-white e é solúvel em água, o que facilita sua absorção no corpo. Sua fórmula molecular inclui elementos como carbono, hidrogênio, nitrogênio, oxigênio e fósforo, refletindo sua estrutura complexa. Fosfato de sitagliptina monohidratado é tipicamente administrado por via oral e muitas vezes é prescrito em combinação com outros medicamentos antidiabéticos para melhorar o controle glicêmico. Assim como qualquer medicamento, é essencial monitorar possíveis efeitos colaterais, que podem incluir problemas gastrointestinais ou reações alérgicas. No geral, Fosfato de sitagliptina monohidratado representa um avanço significativo no tratamento do diabetes, oferecendo uma abordagem direcionada para gerenciar os níveis de açúcar no sangue.
Fórmula:C16H15F6N5O·H3O4P·H2O
InChI:InChI=1S/C16H15F6N5O.H3O4P.H2O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22;1-5(2,3)4;/h4,6,9H,1-3,5,7,23H2;(H3,1,2,3,4);1H2/t9-;;/m1../s1
Chave InChI:InChIKey=GQPYTJVDPQTBQC-KLQYNRQASA-N
SMILES:C(F)(F)(F)C=1N2C(CN(C(C[C@@H](CC3=C(F)C=C(F)C(F)=C3)N)=O)CC2)=NN1.P(=O)(O)(O)O.O
Sinónimos:- (2R)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine dihydrogen phosphate monohydrate
- (3R)-3-amino-1-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one phosphate hydrate (1:1:1)
- 1,2,4-Triazolo[4,3-a]pyrazine, 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-, phosphate (1:1), monohydrate
- 1-Butanone, 3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-, (3R)-, phosphate, hydrate (1:1:1)
- 7-[(3R)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine phosphate monohydrate
- Sitagliptin Phosphate Monohydrate
- Sitagliptin phosephate monohydrate
- Sitagliptin phosphate hydrate
Ordenar por
Pureza (%)
0
100
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0
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50
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90
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95
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100
18 produtos.
SITAGLIPTIN PHOSPHATE MONOHYDRATE CRS
CAS:<p>SITAGLIPTIN PHOSPHATE MONOHYDRATE CRS</p>Cor e Forma:AddedSitagliptin Phosphate
CAS:<p>Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure</p>Fórmula:C16H15F6N5O·H3PO4·H2OCor e Forma:White Off-White PowderPeso molecular:523.105541,2,4-Triazolo[4,3-a]pyrazine,7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-, phosphate (1:1), monohydrate
CAS:Fórmula:C16H20F6N5O6PPureza:98%Cor e Forma:SolidPeso molecular:523.3241Sitagliptin phosphate monohydrate
CAS:<p>Sitagliptin phosphate monohydrate</p>Pureza:≥98%Peso molecular:523.33g/molSitagliptin phosphate monohydrate
CAS:<p>Sitagliptin phosphate monohydrate</p>Pureza:98%Peso molecular:523.32g/molSitagliptin phosphate monohydrate
CAS:Fórmula:C16H15F6N5O·H3PO4·H2OPureza:≤ 0.5%Cor e Forma:White to almost white powderPeso molecular:505.31Sitagliptin Monophosphate Monohydrate
CAS:Fórmula:C16H15F6N5O·H2O·H3O4PCor e Forma:White To Off-White SolidPeso molecular:407.32 18.02 98.00Sitagliptin Phosphate Monohydrate
CAS:Produto ControladoFórmula:C16H15F6N5O·H2O·H3O4PCor e Forma:NeatPeso molecular:523.32Sitagliptin phosphate hydrate
CAS:Fórmula:C16H15F6N5O·H3PO4·xH2OPureza:≥ 98.0% (anhydrous)Cor e Forma:White to off-white powderPeso molecular:505.31Sitagliptin phosphate monohydrate
CAS:<p>Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.</p>Fórmula:C16H15F6N5O·H3PO4·H2OPureza:99.85% - 99.98%Cor e Forma:White Or Almost White Crystalline PowderPeso molecular:523.33Sitagliptin Phosphate Monohydrate (Secondary Standards Traceable to USP)
CAS:Fórmula:C16H15F6N5OH3O4PH2OPeso molecular:407.3 : 98.0 : 18.0Sitagliptin phosphate monohydrate - Bio-X ™
CAS:<p>Sitagliptin is a drug that can be used to treat type 2 diabetes. This drug increases the production of an incretin hormone called glucagon-like peptide-1 (GLP-1) by stimulating the GLP-1 receptor. Sitagliptin is used in combination with metformin or a thiazolidinedione to improve glycemic control in patients with type 2 diabetes mellitus. Sitagliptin has been shown to improve postprandial blood glucose levels and reduce the risk of cardiovascular events. It also reduces the incidence of myocardial infarction and congestive heart failure in patients with type 2 diabetes who are already at high risk for these conditions.</p>Fórmula:C16H20F6N5O6PPureza:(%) Min. 95%Cor e Forma:PowderPeso molecular:523.32 g/molSitagliptin phosphate monohydrate
CAS:<p>Sitagliptin phosphate monohydrate is a DPP-IV inhibitor that is used to treat type 2 diabetes mellitus. Sitagliptin decreases postprandial glucose levels and improves glycemic control. It binds to the enzyme DPP-IV, which breaks down peptides in the small intestine, inhibiting the breakdown of incretin hormones such as glucagon-like peptide 1 and glucose transporter type 2 (GLUT2). This leads to increased levels of GLP-1. Sitagliptin also has been shown to have an anti-diabetic effect by increasing insulin release from pancreatic beta cells.</p>Fórmula:C16H20F6N5O6PPureza:Min. 95%Cor e Forma:White PowderPeso molecular:523.32 g/mol
![1,2,4-Triazolo[4,3-a]pyrazine,7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrah…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA00IBHW.jpg&w=3840&q=75)
