CAS 65710-07-8

Sulfato de apramicina

Descrição:

Sulfato de apramicina é um antibiótico aminoglicosídeo derivado da bactéria *Micromonospora purpurea*. É utilizado principalmente na medicina veterinária para o tratamento de infecções bacterianas em gado e aves. O composto exibe uma atividade antibacteriana de amplo espectro, particularmente contra bactérias Gram-negativas, e é eficaz no tratamento de infecções causadas por certas cepas de *Escherichia coli* e *Salmonella*. A apramicina funciona inibindo a síntese de proteínas bacterianas, ligando-se à subunidade ribossomal 30S, o que interrompe o processo de tradução. A forma sulfato melhora sua solubilidade e estabilidade em soluções aquosas, tornando-a adequada para injeção ou administração oral. Em termos de segurança, a apramicina é geralmente bem tolerada em animais, mas deve-se ter cuidado para evitar a nefrotoxicidade e ototoxicidade potenciais, efeitos colaterais comuns associados aos aminoglicosídeos. Seu uso em animais produtores de alimentos está sujeito a regulamentações para prevenir resíduos de antibióticos em produtos cárneos. No geral, Sulfato de apramicina é uma ferramenta valiosa na medicina veterinária, contribuindo para o manejo de doenças infecciosas em gado.

Fórmula: C₂₁H₄₁N₅O₁₁·xH₂O₄S

InChI: InChI=1S/C21H41N5O11.H2O4S/c1-26-11-14(30)18-8(33-20(11)37-21-16(32)13(29)10(25)9(4-27)34-21)3-7(24)19(36-18)35-17-6(23)2-5(22)12(28)15(17)31;1-5(2,3)4/h5-21,26-32H,2-4,22-25H2,1H3;(H2,1,2,3,4)/t5-,6+,7-,8+,9-,10-,11+,12+,13+,14-,15-,16-,17-,18+,19+,20-,21-;/m1./s1

Chave InChI: InChIKey=WGLYHYWDYPSNPF-RQFIXDHTSA-N

SMILES: O[C@H]1[C@@]2([C@@](O[C@H](O[C@H]3O[C@H](CO)[C@@H](N)[C@H](O)[C@H]3O)[C@H]1NC)(C[C@@H](N)[C@@H](O[C@H]4[C@H](O)[C@@H](O)[C@H](N)C[C@@H]4N)O2)[H])[H].S(=O)(=O)(O)O

Sinónimos:

• (2R,3R,4S,5S,6S)-5-Amino-2-{[(2R,3S,4R,4aR,6S,7R,8aS)-7-amino-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl]oxy}-4-hydroxy-3-(methylamino)octahydropyrano[3,2-b]pyran-2-yl]oxy}-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4-diol sulfate (1:1) (non-preferred name)
• (2R,3R,4S,5S,6S)-5-amino-2-{[(2R,3S,4R,4aR,6S,7R,8aS)-7-amino-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl]oxy}-4-hydroxy-3-(methylamino)octahydropyrano[3,2-b]pyran-2-yl]oxy}-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4-diol sulfate (salt) (non-preferred name)
• (2R,3S,4R,4aR,6S,7R,8aS)-7-Amino-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl]oxy}-4-hydroxy-3-(methylamino)octahydropyrano[3,2-b]pyran-2-yl 4-amino-4-deoxy-alpha-D-glucopyranoside sulfate (1:1)
• (2S,3S,4R,5S,6R)-2-[[(2R,3R,4aR,6S,7R,8S,8aR)-3-amino-2-[(1S,2S,3R,4R,6R)-4,6-diamino-2,3-dihydroxy-cyclohexoxy]-8-hydroxy-7-(methylamino)-2,3,4,4a,6,7,8,8a-octahydropyrano[3,2-b]pyran-6-yl]oxy]-5-amino-6-(hydroxymethyl)tetrahydropyran-3,4-diol
• 265-890-7
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-4-amino-4-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→8)-O-(8R)-2-amino-2,3,7-trideoxy-7-(methylamino)-<smallcap>D</smallcap>-glycero-α-<smallcap>D</span>-allo-octodialdo-1,5:8,4-dipyranosyl-(1→4)-2-deoxy-, sulfate (1:?)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-4-amino-4-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→8)-O-(8R)-2-amino-2,3,7-trideoxy-7-(methylamino)-<smallcap>D</smallcap>-glycero-α-<smallcap>D</span>-allo-octodialdo-1,5:8,4-dipyranosyl-(1→4)-2-deoxy-, sulfate (salt)
• Ai3-29795
• Apramycin Sulfate
• Apramycin, sulfate (2:5)
• D-Streptamine, O-4-amino-4-deoxy-alpha-D-glucopyranosyl-(1-8)-O-(8R)-2-amino-2,3,7-trideoxy-7-(methylamino)-D-glycero-alpha-D-allo-octadialdo-1,5:8,4-dipyranosyl-(1-4)-2-deoxy-, sulfate (salt)
• Sulfuric Acid
• Unii-8Uyl6Naz3Q
• D-Streptamine, O-4-amino-4-deoxy-α-D-glucopyranosyl-(1→8)-O-(8R)-2-amino-2,3,7-trideoxy-7-(methylamino)-D-glycero-α-D-allo-octodialdo-1,5:8,4-dipyranosyl-(1→4)-2-deoxy-, sulfate (salt)

Apramycin sulfate

CAS: 65710-07-8

Apramycin sulfate, 65710-07-8, is the salt of apramycin, a bacteriostatic aminoglycoside antibiotic with activity against gram-negative bacteria. Learn more.

Fórmula: C₂₁H₄₃N₅O₁₅S

Cor e Forma: Pale yellow to yellow-brown powder, Powder

Peso molecular: 637.66

Ref: 02-J66616

Apramycin sulfate, 96%

CAS: 65710-07-8

Potent inhibitor of protein synthesis in bacteria

Fórmula: C₂₁H₄₃N₅O₁₅S

Pureza: 96%

Cor e Forma: Powder, Pale yellow to yellow

Peso molecular: 637.66

Ref: 02-J63874

Apramycin sulfate

CAS: 65710-07-8

Apramycin sulfate (Nebramycin II) is an aminoglycoside antibiotic.

Fórmula: C₂₁H₄₃N₅O₁₅S

Pureza: 99.14% - 99.96%

Cor e Forma: Powder

Peso molecular: 637.66

Ref: TM-T1084

Apramycin sulphate

CAS: 65710-07-8

Apramycin sulphate

Fórmula: C₂₁H₄₁N₅O₁₁·H₂SO₄

Cor e Forma: light brown powder

Peso molecular: 637.66g/mol

Ref: 54-BIA0164

Apramycin sulfate salt

CAS: 65710-07-8

Fórmula: C₂₁H₄₁N₅O₁₁·xH₂SO₄

Pureza: Apramycin: ≥ 550μg/mg (anhydrous basis)

Cor e Forma: Yellow to dark yellow powder

Peso molecular: 539.58 (free base)

Ref: 7W-GA8829

Apramycin sulfate

CAS: 65710-07-8

Apramycin sulfate

Pureza: ≥98%

Peso molecular: 637.66g/mol

Ref: 54-BUP18347

Apramycin Sulfate

CAS: 65710-07-8

Fórmula: C₂₁H₄₁N₅O₁₁·xH₂SO₄

Pureza: >90.0%(HPLC)

Cor e Forma: Light yellow to Yellow powder to crystal

Ref: 3B-A3395

Apramycin sulfate

Produto Controlado

CAS: 65710-07-8

Fórmula: C₂₁H₄₁N₅O₁₁·H₂O₄S

Cor e Forma: Neat

Peso molecular: 637.66

Ref: 04-C10293000

Apramycin Sulfate

Produto Controlado

CAS: 65710-07-8

Applications Broad spectrum aminocyclitol antibiotic and component of the Nebramycin complex, produced by a strain of Streptomyces tenebrarius. Antibacterial.
References Thompson, R.Q., et al.: Antimicrob. Agents Chemother., 332 (1967), Ryden, R., et al.: J. Antimicrob. Chemother., 3, 609 (1977), Smith, P., et al.: Clin. Therap., 23, 1231 (2001),

Fórmula: C₂₁H₄₁N₅O₁₁·H₂O₄S

Cor e Forma: Neat

Peso molecular: 637.66

Ref: TR-A729600

Apramycin sulfate

CAS: 65710-07-8

Apramycin sulfate is a semisynthetic antibiotic that inhibits the growth of Gram-negative bacteria. It is a sulfonamide and has been used in clinical isolates to treat bacterial infections. Apramycin sulfate inhibits the biosynthesis of folic acid, which is important for DNA synthesis and cell division. It also inhibits the production of RNA by binding to ribosomes and inhibiting protein synthesis. Apramycin has been shown to have anticancer properties as well, with studies showing that it can inhibit tumor growth in vitro and in vivo.

Fórmula: C₂₁H₄₁N₅O₁₁·H₂SO₄

Pureza: Min. 550 Usp U/Mg

Cor e Forma: Brown Slightly Yellow Yellow Powder

Peso molecular: 637.66 g/mol

Ref: 3D-AA15315

Apramycin Sulfate

CAS: 65710-07-8

Fórmula: C₂₁H₄₁N₅O₁₁H₂O₄S

Peso molecular: 539.6 : 98.1

Ref: ST-EA-CP-A105002