CAS 66085-59-4

Nimodipina

Descrição:

Nimodipina é um bloqueador de canais de cálcio dihidropiridínico usado principalmente no campo médico por sua capacidade de melhorar o fluxo sanguíneo cerebral. É particularmente indicado para a prevenção de déficits neurológicos isquêmicos após hemorragia subaracnoidea. O composto é caracterizado por sua ação seletiva sobre os vasos sanguíneos cerebrais, levando à vasodilatação sem afetar significativamente a pressão arterial sistêmica. Nimodipina tem uma lipofilicidade relativamente alta, o que facilita sua penetração na barreira hematoencefálica. Sua estrutura química inclui um anel de 1,4-dihidropiridina, que é essencial para sua atividade farmacológica. A substância é tipicamente administrada por via oral ou intravenosa, e sua farmacocinética envolve rápida absorção e metabolismo, com uma meia-vida relativamente curta. Efeitos colaterais comuns podem incluir dor de cabeça, hipotensão e distúrbios gastrointestinais. Devido à sua ação específica e perfil de efeitos colaterais, Nimodipina é um agente terapêutico valioso em neurologia, particularmente no manejo de condições relacionadas ao vasoespasmo cerebral.

Fórmula: C₂₁H₂₆N₂O₇

InChI: InChI=1/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,17,19H,9-10H2,1-5H3/t17?,19-/m0/s1

Chave InChI: InChIKey=UIAGMCDKSXEBJQ-UHFFFAOYSA-N

SMILES: C(OCCOC)(=O)C=1C(C(C(OC(C)C)=O)=C(C)NC1C)C2=CC(N(=O)=O)=CC=C2

Sinónimos:

• 1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-3,5-Pyridinedicarboxylic Acid 2-Methoxyethyl 1-Methylethyl Ester
• 2-Methoxyethyl Propan-2-Yl 2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 1-methylethyl ester
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-(2-methoxyethyl) 5-(1-methylethyl) ester
• 3-(2-methoxyethyl) 5-(1-methylethyl) (4R)-2,6-dimethyl-4-(3-nitrophenyl)-3,4-dihydropyridine-3,5-dicarboxylate
• 3-(2-methoxyethyl) 5-(1-methylethyl) (4S)-2,6-dimethyl-4-(3-nitrophenyl)-3,4-dihydropyridine-3,5-dicarboxylate
• 3-O-(2-Methoxyethyl) 5-O-propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• Admon
• BAY-e 9736
• Isopropyl 2-Methoxyethyl 1,4-Dihydro-2,6-Dimethyl-4-(M-Nitrophenyl)-3,5-Pyridinedicarboxylate
• Nemotan
• Nimodipin
• Nimodipine AP
• Nimodipino
• Nimotop
• Periplum
• Nimodipine
• inedicarboxylate
• 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID 2-METHYLOXYETHYL 1-METHYLETHYL ESTER
• isopropyl2-methoxyethyl1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyrid
• Bay e 9736, Admon, Nimotop, periplum
• NIMODIPINE EPN(CRM STANDARD)
• NIMODIPINE MM(CRM STANDARD)
• NIMODIPINE BP STANDARD(CRM STANDARD)
• 1,4-Dihydro-2,6-dimethyl-4-(3-ni-trophenyl)-3,5-pyridinedicarboxylicacid
• NIMODIPINE CALCIUM CHANNEL ANTAG
• ethoxyethyl1-methylethylester

Nimodipine, 98+%

CAS: 66085-59-4

Potent L-type calcium channel antagonist

Fórmula: C₂₁H₂₆N₂O₇

Pureza: 98+%

Cor e Forma: Powder

Peso molecular: 418.45

Ref: 02-J61287

Nimodipine

CAS: 66085-59-4

Cor e Forma: Neat

Ref: 61-FOR0416.00

Nimodipine

CAS: 66085-59-4

Nimodipine

Fórmula: C₂₁H₂₆N₂O₇

Pureza: 100.0%

Cor e Forma: Yellow Solid

Peso molecular: 418.174

Ref: 47-651

NIMODIPINE CRS

CAS: 66085-59-4

NIMODIPINE CRS

Fórmula: C₂₁H₂₆N₂O₇

Peso molecular: 418.4403

Ref: 41-N0850000

Nimodipine

CAS: 66085-59-4

Compounds containing an unfused pyridine ring in the structure, nesoi

Fórmula: C₂₁H₂₆N₂O₇

Cor e Forma: Yellow Crystalline Powder

Peso molecular: 418.174

Ref: 45-1463858

Nimodipine

CAS: 66085-59-4

Nimodipine (BAY-e 9736), a 1, 4-dihydropyridine calcium channel blocker, acts primarily on vascular smooth muscle cells.

Fórmula: C₂₁H₂₆N₂O₇

Pureza: 99.64% - 99.79%

Cor e Forma: Solid

Peso molecular: 418.44

Ref: TM-T0343

Nimodipine

CAS: 66085-59-4

Nimodipine

Pureza: 98%

Peso molecular: 418.44g/mol

Ref: 54-OR1030244

Nimodipine

CAS: 66085-59-4

Fórmula: C₂₁H₂₆N₂O₇

Pureza: ≥ 98.0% (anhydrous basis)

Cor e Forma: Off-white to yellow powder

Peso molecular: 418.44

Ref: 7W-GP2955

Nimodipine

CAS: 66085-59-4

Nimodipine

Pureza: ≥98%

Peso molecular: 418.44g/mol

Ref: 54-BUP14874

Nimodipine

CAS: 66085-59-4

Fórmula: C₂₁H₂₆N₂O₇

Cor e Forma: Yellow Solid

Peso molecular: 418.45

Ref: 4Z-N-151

Nimodipine

Produto Controlado

CAS: 66085-59-4

Fórmula: C₂₁H₂₆N₂O₇

Cor e Forma: Neat

Peso molecular: 418.44

Ref: 86-MM0416.00

Nimodipine 100 µg/mL in Acetonitrile

CAS: 66085-59-4

Fórmula: C₂₁H₂₆N₂O₇

Cor e Forma: Single Solution

Peso molecular: 418.44

Ref: 04-A15526800AL-100

Nimodipine

CAS: 66085-59-4

Fórmula: C₂₁H₂₆N₂O₇

Cor e Forma: Neat

Peso molecular: 418.44

Ref: 04-C15526800

Nimodipine

CAS: 66085-59-4

Fórmula: C₂₁H₂₆N₂O₇

Pureza: >98.0%(HPLC)

Cor e Forma: White to Light yellow powder to crystal

Peso molecular: 418.45

Ref: 3B-N0896

Nimodipine

CAS: 66085-59-4

Applications A dihydropyridine calcium channel blocker. It is used as a vasodilator (cerebral). Neuroprotective & Neuroresearch products.
References Allen, G.S., et al.: N. Engl. J. Med., 308, 619 (1983), Schluter, H.: Arzneim.-Forsch., 36, 1733 (1986), Deyo, R.A., et al.: Science, 243, 809 (1989),

Fórmula: C₂₁H₂₆N₂O₇

Cor e Forma: Neat

Peso molecular: 418.44

Ref: TR-N478200

Nimodipine

CAS: 66085-59-4

Nimodipine is a medication that belongs to the group of calcium channel blockers. It is used as a treatment for cerebral vasospasm, subarachnoid hemorrhage, and hypertensive emergencies. Nimodipine inhibits calcium influx into cells by blocking voltage-sensitive L-type calcium channels in smooth muscle cells. This medication has been shown to be effective when used with other drugs in the treatment of vasospasm or after aneurysm surgery. Nimodipine has also been shown to increase blood flow and improve brain function in patients with head injuries. The effects of nimodipine on cerebral blood flow have been demonstrated using whole-cell recordings from brain slices.

Fórmula: C₂₁H₂₆N₂O₇

Pureza: Min. 98 Area-%

Cor e Forma: Slightly Yellow Powder

Peso molecular: 418.44 g/mol

Ref: 3D-II57946

Nimodipine

CAS: 66085-59-4

M02160 - Nimodipine

Fórmula: C₂₁H₂₆N₂O₇

Pureza: 95%

Cor e Forma: Solid

Peso molecular: 418.446

Ref: 10-M02160