CAS 66701-25-5

trans-Epoxissuccinil-L-leucilamido-(4-guanidino)butano

Descrição:

trans-Epoxissuccinil-L-leucilamido-(4-guanidino)butano, identificado pelo seu número CAS 66701-25-5, é um composto sintético que exibe características típicas de estruturas semelhantes a peptídeos. Esta substância apresenta um grupo funcional epóxido, que contribui para sua reatividade, particularmente em sistemas biológicos onde pode interagir com nucleófilos. A presença de um grupo guanidino sugere uma potencial atividade biológica, uma vez que compostos guanidinos estão frequentemente envolvidos na inibição ou modulação de enzimas. O componente L-leucilamido indica que é derivado do aminoácido leucina, o que pode influenciar sua interação com receptores biológicos ou enzimas. Além disso, a estrutura geral sugere que pode possuir propriedades relevantes para a química medicinal, particularmente no desenvolvimento de agentes terapêuticos direcionados a vias biológicas específicas. Sua estabilidade, solubilidade e reatividade dependeriam das condições circundantes, como pH e temperatura, tornando-o um composto de interesse para futuras pesquisas em farmacologia e bioquímica.

Fórmula: C₁₅H₂₇N₅O₅

InChI: InChI=1S/C15H27N5O5/c1-8(2)7-9(20-13(22)10-11(25-10)14(23)24)12(21)18-5-3-4-6-19-15(16)17/h8-11H,3-7H2,1-2H3,(H,18,21)(H,20,22)(H,23,24)(H4,16,17,19)/t9-,10-,11-/m0/s1

Chave InChI: InChIKey=LTLYEAJONXGNFG-DCAQKATOSA-N

SMILES: C(N[C@H](C(NCCCCNC(=N)N)=O)CC(C)C)(=O)[C@@H]1[C@@H](C(O)=O)O1

Sinónimos:

• (2R,3R)-3-{[(2S)-1-({4-[(diaminomethylidene)amino]butyl}amino)-4-methyl-1-oxopentan-2-yl]carbamoyl}oxirane-2-carboxylic acid
• (2S,3S)-3-[[[(1S)-1-[[[4-[(Aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-2-oxiranecarboxylic acid
• (2S,3S)-3-{[(2S)-1-({4-[(diaminomethylidene)amino]butyl}amino)-4-methyl-1-oxopentan-2-yl]carbamoyl}oxirane-2-carboxylic acid
• 2-Oxiranecarboxylic acid, 3-[[[(1S)-1-[[[4-[(aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-, (2S,3S)-
• E 64 (proteinase inhibitor)
• E-64
• E-64 Protease Inhibitor
• E64
• Oxiranecarboxylic acid, 3-[[[(1S)-1-[[[4-[(aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-, (2S,3S)-
• Oxiranecarboxylic acid, 3-[[[1-[[[4-[(aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-, [2S-[2α,3β(R*)]]-
• Proteinase inhibitor E 64
• trans-Epoxysuccinyl-<span class="text-smallcaps">L</span>-leucylamido-(4-guanidino)butane
• trans-Epoxysuccinyl-L-leucylamido(4-guanidino)butane

E-64

CAS: 66701-25-5

Selective and irreversible cysteine protease inhibitor

Fórmula: C₁₅H₂₇N₅O₅

Cor e Forma: White to pale cream, Crystals or powder or crystalline powder

Peso molecular: 357.4

Ref: 02-J62933

L-trans-Epoxysuccinyl-Leu-4-guanidinobutylamide

CAS: 66701-25-5

Most commonly used diagnostic inhibitor for the characterization of cysteine proteinases. Originally isolated from cultures of Aspergillus japonicus, E64 is a non-competitive, irreversible inhibitor of thiol proteinases of the papain and calpain families.

Fórmula: C₁₅H₂₇N₅O₅

Pureza: 99.7%

Peso molecular: 357.41

Ref: 01-4027910

E-64

CAS: 66701-25-5

Fórmula: C₁₅H₂₇N₅O₅

Pureza: 99%

Cor e Forma: Solid

Peso molecular: 357.4054

Ref: IN-DA0036TL

E-64

CAS: 66701-25-5

E-64

Pureza: ≥98%

Peso molecular: 357.41g/mol

Ref: 54-BUP13066

E-64

CAS: 66701-25-5

E-64

Fórmula: C₁₅H₂₇N₅O₅

Pureza: 95%

Cor e Forma: white to off-white powder

Peso molecular: 357.41g/mol

Ref: 54-BIMI2157

E-64 protease inhibitor

CAS: 66701-25-5

Fórmula: C₁₅H₂₇N₅O₅

Pureza: (HPLC) ≥ 98.0%

Cor e Forma: White crystalline powder

Peso molecular: 357.40

Ref: 7W-GL4130

E-64

CAS: 66701-25-5

Fórmula: C₁₅H₂₇N₅O₅

Peso molecular: 357.41

Ref: 4Z-E-189001

E-64

CAS: 66701-25-5

E-64 (Proteinase inhibitor E 64) is an irreversible and specific cysteine protease inhibitor. The IC50 of E-64 for papain is 9 nM.

Fórmula: C₁₅H₂₇N₅O₅

Pureza: 98% - 99.95%

Cor e Forma: White Solid

Peso molecular: 357.41

Ref: TM-T6037

E 64

Produto Controlado

CAS: 66701-25-5

Fórmula: C₁₅H₂₇N₅O₅

Cor e Forma: Neat

Peso molecular: 357.41

Ref: TR-E100490

E-64

CAS: 66701-25-5

Inhibitor of cathepsins and other cysteine proteases

Fórmula: C₁₅H₂₇N₅O₅

Pureza: Min. 98 Area-%

Cor e Forma: White Powder

Peso molecular: 357.41 g/mol

Ref: 3D-FE29621

E-64

CAS: 66701-25-5

E-64 is a chemical inhibitor that binds to the ATP synthase in mitochondria, inhibiting oxidative phosphorylation. This inhibition of mitochondrial energy production leads to cell death by apoptosis. E-64 has been shown to inhibit tumor growth in vitro and in vivo by inducing autophagy and inhibiting cancer cell proliferation. E-64 has also been shown to have proteolytic activity against serum proteins, which may be due to its ability to bind to the phosphate groups of proteins.

Fórmula: C₁₅H₂₇N₅O₅H₂O

Pureza: Min. 95%

Peso molecular: 366.42 g/mol

Ref: 3D-IES-4096

E 64-d8

Produto Controlado

CAS: 66701-25-5

Fórmula: C₁₅D₈H₁₉N₅O₅

Cor e Forma: Neat

Peso molecular: 365.455

Ref: TR-E100492

E-64

CAS: 66701-25-5

E-64 is a research tool that is used to study protein interactions. It has been shown to inhibit ion channels, such as the nicotinic acetylcholine receptor and the voltage-gated calcium channel. E-64 binds to receptors in the cell membrane, blocking ion channels and altering intracellular signaling pathways. E-64 has been shown to inhibit nitric oxide synthase, which may account for its anti-inflammatory properties. E-64 also inhibits an enzyme called protein tyrosine phosphatase 1B (PTP1B), which is involved in insulin resistance and type 2 diabetes mellitus.

Fórmula: C₁₅H₂₇N₅O₅

Pureza: Min. 95%

Peso molecular: 357.41 g/mol

Ref: 3D-IES-4096-V