CAS 67814-76-0

D-Estreptamina, O-6-amino-6-desoxi-α-D-glucopiranosil-(1→4)-O-[3-desoxi-4-C-metil-3-(metilamino)-β-L-arabinopiranosil-(1→6)]-N1-[(2S)-3-amino-2-hidroxi-1-oxopropil]-2-desoxi-, sulfato (1:?)

Descrição:

D-Estreptamina, O-6-amino-6-desoxi-α-D-glucopiranosil-(1→4)-O-[3-desoxi-4-C-metil-3-(metilamino)-β-L-arabinopiranosil-(1→6)]-N1-[(2S)-3-amino-2-hidroxi-1-oxopropil]-2-desoxi-, sulfato (1:?) é um antibiótico aminoglicosídeo glicosilado complexo. É caracterizado por sua estrutura intrincada, que inclui múltiplos grupos de açúcar e um componente de aminoácido, contribuindo para sua atividade biológica. A presença de grupos sulfato aumenta sua solubilidade e estabilidade em sistemas biológicos. Este composto exibe propriedades antibacterianas, visando principalmente os ribossomos bacterianos para inibir a síntese de proteínas, tornando-o eficaz contra uma variedade de bactérias Gram-negativas. Suas características estruturais únicas, incluindo as ligações glicosídicas específicas e grupos funcionais, são cruciais para sua interação com os alvos bacterianos. Além disso, a estereoquímica do composto desempenha um papel significativo em seu perfil farmacológico. Como muitos aminoglicosídeos, pode ter efeitos colaterais potenciais, incluindo nefrotoxicidade e ototoxicidade, o que requer consideração cuidadosa em aplicações terapêuticas. No geral, a D-estreptamina representa uma classe significativa de antibióticos com importante relevância clínica.

Fórmula: C₂₂H₄₃N₅O₁₂·xH₂O₄S

InChI: InChI=1S/C22H43N5O12.H2O4S/c1-22(35)6-36-20(15(33)18(22)26-2)39-17-8(27-19(34)9(28)4-23)3-7(25)16(14(17)32)38-21-13(31)12(30)11(29)10(5-24)37-21;1-5(2,3)4/h7-18,20-21,26,28-33,35H,3-6,23-25H2,1-2H3,(H,27,34);(H2,1,2,3,4)/t7-,8+,9-,10+,11+,12-,13+,14-,15+,16+,17-,18+,20+,21+,22-;/m0./s1

Chave InChI: InChIKey=DDXRHRXGIWOVDQ-MGAUJLSLSA-N

SMILES: O([C@H]1[C@H](NC([C@H](CN)O)=O)C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@@H]1O)[C@@H]3[C@H](O)[C@@H](NC)[C@@](C)(O)CO3.S(=O)(=O)(O)O

Sinónimos:

• (2S)-3-amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxy-oxan-2-yl]oxy-2-[(2R,3R,4R,5S)-3,5-dihydroxy-5-methyl-4-methylamino-oxan-2-yl]oxy-3-hydroxy-cyclohexyl]-2-hydroxy-propanamide sulfate
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-6-amino-6-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-<smallcap>L</span>-arabinopyranosyl-(1→6)]-N¹-(3-amino-2-hydroxy-1-oxopropyl)-2-deoxy-, (S)-, sulfate (salt)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-6-amino-6-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-<smallcap>L</span>-arabinopyranosyl-(1→6)]-N¹-[(2S)-3-amino-2-hydroxy-1-oxopropyl]-2-deoxy-, sulfate (1:?)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-6-amino-6-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-<smallcap>L</span>-arabinopyranosyl-(1→6)]-N¹-[(2S)-3-amino-2-hydroxy-1-oxopropyl]-2-deoxy-, sulfate (salt)
• Exacin
• Isepacin
• D-Streptamine, O-6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)]-N1-(3-amino-2-hydroxy-1-oxopropyl)-2-deoxy-, (S)-, sulfate (salt)
• D-Streptamine, O-6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)]-N1-[(2S)-3-amino-2-hydroxy-1-oxopropyl]-2-deoxy-, sulfate (1:?)
• D-Streptamine, O-6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)]-N1-[(2S)-3-amino-2-hydroxy-1-oxopropyl]-2-deoxy-, sulfate (salt)
• Isepamicin sulfate

Isepamicin Sulfate

CAS: 67814-76-0

Fórmula: C₂₂H₄₅N₅O₁₆S

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 667.6816

Ref: IN-DA01DQ46

Isepamicin Sulfate

CAS: 67814-76-0

Isepamicin Sulfate

Pureza: 99%, ≥670μg/mg

Peso molecular: 667.68g/mol

Ref: 54-OR1025300

Isepamicin sulfate

CAS: 67814-76-0

Isepamicin sulfate

Pureza: ≥98%

Peso molecular: 667.68g/mol

Ref: 54-BUP06503

Isepamicin sulfate

CAS: 67814-76-0

Isepamicin sulfate (sch21420), an aminoglycoside, targets 30S ribosomal unit, effective against type I 6-acetyltransferase strains.

Fórmula: C₂₂H₄₃N₅O₁₂·SH₂O₄

Pureza: 99.31% - 99.91%

Cor e Forma: Solid

Peso molecular: 667.68

Ref: TM-T6549

Isepamicin Sulfate

CAS: 67814-76-0

Fórmula: C₂₂H₄₃N₅O₁₂·H₂SO₄

Peso molecular: 569.61 98.08

Ref: 4Z-I-157001

Isepamicin sulfate

CAS: 67814-76-0

Fórmula: C₂₂H₄₃N₅O₁₂

Pureza: ≥ 670μg/mg

Cor e Forma: White to off-white powder

Peso molecular: 569.60

Ref: 7W-GA5158

Isepamicin Sulfate

CAS: 67814-76-0

Stability Hygroscopic
Applications Isepamicin sulfate (CAS# 67814-76-0) is an aminoglycoside antibiotic with excellent capability of transference from venous blood to bone marrow blood.
References Li, G.; et al.: Zhongguo Xiandai Yixue Zazhi, 17, 1507 (2007).

Fórmula: C₂₂H₄₃N₅O₁₂•H₂O₄S

Cor e Forma: Off-White

Peso molecular: 569.609808

Ref: TR-I927013

Isepamicin sulphate

CAS: 67814-76-0

Isepamicin Sulphate is an aminoglycoside antibiotic with a mode of action that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. It is used for treating infections caused by gram-negative bacteria.

Fórmula: C₂₂H₄₃N₅O₁₂•H₂SO₄

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 667.68 g/mol

Ref: 3D-FI65046

Isepamicin sulfate - 70%

CAS: 67814-76-0

Isepamicin sulfate - 70% is a semi-synthetic aminoglycoside antibiotic, which is derived from naturally occurring antibiotic compounds through chemical modifications. Its mode of action involves binding to the bacterial 30S ribosomal subunit, disrupting protein synthesis and consequently causing bacterial cell death. This mechanism of action is typical of aminoglycosides, characterized by their bactericidal properties against a broad spectrum of Gram-negative bacteria, with some efficacy against certain Gram-positive bacterial strains.

Fórmula: C₂₂H₄₅N₅O₁₆S

Pureza: Min. 95%

Cor e Forma: White/Off-White Solid

Peso molecular: 667.68 g/mol

Ref: 3D-FI163230