CAS 67915-31-5

Terconazol

Descrição:

Terconazol é um agente antifúngico usado principalmente no tratamento de infecções vaginais por fungos causadas por espécies de Candida. Pertence à classe dos antifúngicos triazólicos, que funcionam inibindo a síntese de ergosterol, um componente essencial das membranas celulares fúngicas, interrompendo assim sua integridade e levando à morte celular. Terconazol é tipicamente administrado como um creme tópico ou supositório vaginal, permitindo um tratamento localizado com mínima absorção sistêmica. A substância é caracterizada por sua relativamente baixa solubilidade em água, mas é solúvel em solventes orgânicos, o que ajuda em sua formulação. Terconazol exibe um amplo espectro de atividade contra vários fungos, particularmente Candida albicans. Sua farmacocinética indica uma duração prolongada de ação, tornando-o eficaz com menos doses. Os efeitos colaterais são geralmente leves e podem incluir irritação local ou reações alérgicas. No geral, Terconazol é uma opção valiosa na terapia antifúngica, particularmente para pacientes que buscam tratamento localizado para infecções vaginais.

Fórmula: C₂₆H₃₁Cl₂N₅O₃

InChI: InChI=1/C26H31Cl2N5O3/c1-19(2)31-9-11-32(12-10-31)21-4-6-22(7-5-21)34-14-23-15-35-26(36-23,16-33-18-29-17-30-33)24-8-3-20(27)13-25(24)28/h3-8,13,17-19,23H,9-12,14-16H2,1-2H3/t23-,26-/s2

Chave InChI: InChIKey=BLSQLHNBWJLIBQ-MKNUCDGGNA-N

SMILES: C([C@]1(O[C@@H](COC2=CC=C(C=C2)N3CCN(C(C)C)CC3)CO1)C4=C(Cl)C=C(Cl)C=C4)N5C=NC=N5

Sinónimos:

• (.+-.)-Terconazole
• Fungistat
• Gyno-Terazol
• Nsc 331942
• Piperazine, 1-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-(1-methylethyl)-, cis-
• R 42470
• Terazol
• Terazol Cream & Suppositories
• Terconazol
• Tercospor
• Termayazole
• Triaconazole
• rel-1-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-(1-methylethyl)piperazine
• 1-(4-{[(4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)-4-(propan-2-yl)piperazine
• Terconagole
• 1-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)-4-(propan-2-yl)piperazine
• TERCONAZOLE USP(CRM STANDARD)
• 1-(4-{[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)-4-(propan-2-yl)piperazine
• 1-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-propan-2-yl-piperazine
• TERCONAZOLE EPT(CRM STANDARD)
• Piperazine, 1-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-(1-methylethyl)-, rel-

TERCONAZOLE CRS

CAS: 67915-31-5

TERCONAZOLE CRS

Ref: 41-T0060000

Terconazole

CAS: 67915-31-5

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Fórmula: C₂₆H₃₁Cl₂N₅O₃

Cor e Forma: White Off-White Powder

Peso molecular: 531.1804

Ref: 45-1643703

Piperazine,1-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-(1-methylethyl)-, rel-

CAS: 67915-31-5

Fórmula: C₂₆H₃₁Cl₂N₅O₃

Pureza: 97%

Cor e Forma: Solid

Peso molecular: 532.4620

Ref: IN-DA00IBRL

Terconazole

CAS: 67915-31-5

Fórmula: C₂₆H₃₁Cl₂N₅O₃

Cor e Forma: White To Off-White Solid

Peso molecular: 532.47

Ref: 4Z-T-142009

Terconazole

CAS: 67915-31-5

Fórmula: C₂₆H₃₁Cl₂N₅O₃

Peso molecular: 532.46

Ref: 7W-GP4833

1-(4-(((2R,4S)-2-((1H-1,2,4-Triazol-1-Yl)Methyl)-2-(2,4-Dichlorophenyl)-1,3-Dioxolan-4-Yl)Methoxy)Phenyl)-4-Isopropylpiperazine

CAS: 67915-31-5

1-(4-(((2R,4S)-2-((1H-1,2,4-Triazol-1-Yl)Methyl)-2-(2,4-Dichlorophenyl)-1,3-Dioxolan-4-Yl)Methoxy)Phenyl)-4-Isopropylpiperazine

Pureza: 97%

Peso molecular: 532.46g/mol

Ref: 54-OR1025957

Terconazole

CAS: 67915-31-5

Terconazole

Pureza: ≥98%

Peso molecular: 532.46g/mol

Ref: 54-BUP13962

Terconazole

Produto Controlado

CAS: 67915-31-5

Fórmula: C₂₆H₃₁Cl₂N₅O₃

Cor e Forma: Neat

Peso molecular: 532.46

Ref: 04-C17320500

Terconazole

Produto Controlado

CAS: 67915-31-5

Fórmula: C₂₆H₃₁Cl₂N₅O₃

Cor e Forma: Neat

Peso molecular: 532.46

Ref: 86-MM1286.00

Terconazole

CAS: 67915-31-5

Terconazole, a triazole antifungal, disrupts fungal cell walls by inhibiting ergosterol synthesis, active against Candida.

Fórmula: C₂₆H₃₁Cl₂N₅O₃

Pureza: 98% - 99.60%

Cor e Forma: Solid

Peso molecular: 532.46

Ref: TM-T2213

Terconazole-d8

CAS: 67915-31-5

Fórmula: C₂₆H₂₃D₈Cl₂N₅O₃

Peso molecular: 540.51

Ref: 4Z-T-142010

Terconazole

CAS: 67915-31-5

Terconazole is an azole antifungal agent with action on fungal cell membranes by inhibiting ergosterol biosynthesis and is used for treating vaginal yeast infections.

Fórmula: C₂₆H₃₁Cl₂N₅O₃

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 532.46 g/mol

Ref: 3D-FT35141

Terconazole

CAS: 67915-31-5

Fórmula: C₂₆H₃₁Cl₂N₅O₃

Pureza: 97%

Peso molecular: 532.47

Ref: 10-F547226

Terconazole

Produto Controlado

CAS: 67915-31-5

Applications Terconazole belongs to a new chemical class of antifungal agents, the triazoles. Terconazole has a far greater selectively for yeast cytochrome P-450 than for mammalian microsomal cytochrome P-450 and is used as topical treatment of mycotic vaginitis. Terconazole may also be used in vitro as a potent antifungal agent to prevent the morphogenetic transformation of yeast into (pseudo-)mycelium form of Candida albicans.
References Cauwenbergh, G., Vanden Bossch H.: J. Reprod. Med., 34, 588 (1989); Del Palacio-Hernanz, A., et. al.: Chemioterapia, 3, 192 (1984); Van Cutsem, J., et. al.: Chemotherapy, 29, 322 (1983);

Fórmula: C₂₆H₃₁Cl₂N₅O₃

Cor e Forma: White To Off-White

Peso molecular: 532.46

Ref: TR-T110600

Terconazole-d8

Produto Controlado

CAS: 67915-31-5

Fórmula: C₂₆D₈H₂₃Cl₂N₅O₃

Cor e Forma: Neat

Peso molecular: 540.511

Ref: TR-T110602

Terconazole

CAS: 67915-31-5

Cor e Forma: Neat

Ref: 61-FOR1286.00