CAS 68406-26-8

Ginsenosídeo Rb3

Descrição:

Ginsenosídeo Rb3 é uma saponina triterpenoide encontrada principalmente no ginseng, uma planta renomada por suas propriedades medicinais. É um dos muitos ginsenosídeos, que são os compostos ativos que se acredita contribuírem para os benefícios à saúde do ginseng. Ginsenosídeo Rb3 é caracterizado por sua complexa estrutura molecular, que inclui uma espinha dorsal semelhante a um esteroide com múltiplos grupos de açúcar anexados, influenciando sua solubilidade e bioatividade. Este composto é conhecido por seus potenciais efeitos farmacológicos, incluindo propriedades anti-inflamatórias, antioxidantes e neuroprotetoras. Pesquisas sugerem que Ginsenosídeo Rb3 pode melhorar a função cognitiva e exibir efeitos cardioprotetores, tornando-o de interesse tanto na medicina tradicional quanto na farmacologia moderna. Seu mecanismo de ação muitas vezes envolve a modulação de várias vias de sinalização, contribuindo para seu potencial terapêutico. Assim como muitos compostos naturais, a biodisponibilidade e a eficácia de Ginsenosídeo Rb3 podem ser influenciadas por fatores como dosagem, formulação e diferenças metabólicas individuais.

Fórmula: C₅₃H₉₀O₂₂

InChI: InChI=1/C53H90O22/c1-8-23(2)10-9-15-53(7,75-48-44(67)40(63)38(61)31(72-48)22-69-46-42(65)35(58)28(57)21-68-46)25-13-16-52(6)24-11-12-32-50(3,4)33(14-17-51(32,5)26(24)18-27(56)34(25)52)73-49-45(41(64)37(60)30(20-55)71-49)74-47-43(66)39(62)36(59)29(19-54)70-47/h10,24-49,54-67H,8-9,11-22H2,1-7H3/b23-10+/t24?,25?,26?,27-,28+,29+,30+,31+,32?,33?,34?,35-,36+,37+,38+,39-,40+,41-,42+,43+,44+,45+,46-,47-,48-,49-,51+,52+,53+/m0/s1

Chave InChI: InChIKey=NODILNFGTFIURN-USYOXQFSSA-N

SMILES: C[C@]12[C@@]3(C)[C@@]([C@@]([C@@](O[C@@H]4O[C@H](CO[C@H]5[C@H](O)[C@@H](O)[C@H](O)CO5)[C@@H](O)[C@H](O)[C@H]4O)(CCC=C(C)C)C)(CC3)[H])([C@H](O)C[C@@]1([C@]6(C)[C@@](CC2)(C(C)(C)[C@@H](O[C@H]7[C@H](O[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)[C@@H](O)[C@H](O)[C@@H](CO)O7)CC6)[H])[H])[H]

Sinónimos:

• (1R,4E)-1-{(8xi,9xi,12α,13xi,14β)-3-[(2-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-12-hydroxy-4,4,10,14-tetramethylgonan-17-yl}-1,5-dimethylhept-4-en-1-yl 6-O-β-D-xylopyranosyl-β-D-allopyranoside
• (3β,12β)-3-[(2-O-β-<span class="text-smallcaps">D</smallcap>-Glucopyranosyl-β-<smallcap>D</smallcap>-glucopyranosyl)oxy]-12-hydroxydammar-24-en-20-yl 6-O-β-<smallcap>D</smallcap>-xylopyranosyl-β-<smallcap>D</span>-glucopyranoside
• Dammarane, β-<span class="text-smallcaps">D</span>-glucopyranoside deriv.
• Ginsenoside Rb₃
• Gypenoside IV
• alpha-D-Glucopyranoside, (3-beta,12-beta)-3-((2-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy)-12-hydroxydammar-24-en-20-yl 6-O-beta-D-xylopyranosyl-
• β-<span class="text-smallcaps">D</smallcap>-Glucopyranoside, (3β,12β)-3-[(2-O-β-<smallcap>D</smallcap>-glucopyranosyl-β-<smallcap>D</smallcap>-glucopyranosyl)oxy]-12-hydroxydammar-24-en-20-yl 6-O-β-<smallcap>D</span>-xylopyranosyl-
• β-D-Glucopyranoside, (3β,12β)-3-[(2-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-20-yl 6-O-β-D-xylopyranosyl-
• Dammarane, β-D-glucopyranoside deriv.
• (3β,12β)-3-[(2-O-β-D-Glucopyranosyl-β-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-20-yl 6-O-β-D-xylopyranosyl-β-D-glucopyranoside
• Ginsenoside Rb3
• β-D-Glucopyranoside, (3β,12β)-3-[(2-O-β-D-
• NH25835
• Ginsenoside Rb3 ,98%
• [3β-[[2-O-(β-D-Glucopyranosyl)-β-D-glucopyranosyl]oxy]-12β-hydroxy-5α-dammar-24-en-20-yl]6-O-(β-D-xylopyranosyl)-β-D-glucopyranoside
• glucopyranosyl)oxy)-12-hydroxydammar-24-en-20-yl6-o-beta-d-xylopyranosyl-
• xylopyranosyl-
• (3-beta,12-beta)-3-((2-o-beta-d-glucopyranosyl-beta-d-alpha-d-glucopyranosid
• Ginsenoside Rb3, 98%, from Panax ginseng C. A. Mey.
• GINSENOSIDE Rb3(SH)
• (2S,3R,4S,5S,6R)-2-[[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-[[(10R,12S,14R)-12-hydroxy-4,4,10,14-tetramethyl-17-[(E,2R)-6-methyl-2-[[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-[[(2S,3R,4S,5R)-3,4
• hydroxydammar-24-en-20-yl6-O-β-D-

Ginsenoside Rb3

CAS: 68406-26-8

Ginsenoside Rb3 analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Fórmula: C₅₃H₉₀O₂₂

Pureza: (HPLC) ≥97%

Cor e Forma: Powder

Peso molecular: 1079.29

Ref: 11-0151S

Ginsenoside Rb3

CAS: 68406-26-8

Fórmula: C₅₃H₉₀O₂₂

Pureza: ≥ 98.0%

Cor e Forma: White to off-white crystalline powder

Peso molecular: 1079.27

Ref: 7W-GC9541

Ginsenoside Rb3

CAS: 68406-26-8

Ginsenoside Rb3 has anti-myocardial ischemia-reperfusion injury, neuroprotective, antidepressant-like, and antioxidant effects, it also possesses the potential of the clinical use in preventing and treating diabetes. Ginsenoside Rb3 significantly attenuates the changes of creatine kinase activity and lactate dehydrogenase activity, exhibits inhibitory effect on TNFα-induced NF-κB transcriptional activity with an IC50 of 8.2 μM in 293T cell lines, it also inhibits the induction of COX-2 and iNOS mRNA.

Fórmula: C₅₃H₉₀O₂₂

Pureza: 95%~99%

Peso molecular: 1079.28

Ref: BP-BP0659

Ginsenoside Rb3

CAS: 68406-26-8

Fórmula: C₅₃H₉₀O₂₂

Peso molecular: 1079.28

Ref: 4Z-G-157024

Ginsenoside Rb3

CAS: 68406-26-8

Ginsenoside Rb3 (Gypenoside IV) is a natural triterpenoid saponin, exhibiting inhibition effect on TNFα-induced NF-κB transcriptional activity.

Fórmula: C₅₃H₉₀O₂₂

Pureza: 98% - 99.98%

Cor e Forma: Solid

Peso molecular: 1079.27

Ref: TM-T3918

Ginsenoside rb3

CAS: 68406-26-8

Natural glycoside

Fórmula: C₅₃H₉₀O₂₂

Pureza: ≥ 90.0 % (HPLC)

Cor e Forma: Powder

Peso molecular: 1079.29

Ref: 5G-89679

Ginsenoside Rb3

Produto Controlado

CAS: 68406-26-8

Stability Hygroscopic
Applications Ginsenoside Rb3 inhibits the upregulation of phospho-IκB-α and nuclear translocation of NF-κB subunit p65 induced by glucose deprivation then reperfusion.
References Ma, L., et. al.: PloS One, 9, e103628/1-e103628/12 (2014)

Fórmula: C₅₃H₉₀O₂₂

Cor e Forma: Neat

Peso molecular: 1079.27

Ref: TR-G387610

Ginsenoside Rb3

CAS: 68406-26-8

Ginsenoside Rb3 is a natural saponin compound, which is a type of ginsenoside derived from the root of Panax ginseng. The source of Ginsenoside Rb3, Panax ginseng, is a perennial plant widely utilized in traditional medicine for its pharmacological properties.

Fórmula: C₅₃H₉₀O₂₂

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 1,079.27 g/mol

Ref: 3D-OG09286